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고양이에서 실험적 담즙울체 및 간기능부전이 Mivacurium 의 근이완 작용에 미치는 영향
신양식,이상열,최미영,한정욱,박기용 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.2
Background : Duration of action varies in conditions with reduced plasma cholinesterase activity. To evaluate the action duration and recovery of mivacurium under the experimental hepatic failure and cholestasis, the pharmacodynamic studies were done. Methods : The pharmacodynamic studies were done using a common peroneal nerve-anterior tibialis muscle preparation in 18, either sex, adult cats (weight, 2.0∼4.0 ㎏). For the hepatic failure, galactosamine chloride (4.25 mmol/㎏) was given 16 hours prior to the pharmacodynamic study. The cholestasis was made by the ligation of CBD and cystic duct 8 days prior to the pharmacodynamic study. All the cat had 4×ED95 of mivacurium. The action durations and recovery indices were measured. And plasma cholinesterase activities were checked. Results : The duration of mivacurium was prolonged significantly with either hepatic failure (14.96 4.44 min.) or cholestasis (11.21± 5.11 min.) group compared to control group (5.27 ±0.67 min.) and also the recovery indices were icantly increased in the hepatic failure (4.58± 1.40 min.) and cholestasis (3.21± 1.00 min.) groups, as compaired with the control group (1.57± 0.40 min.). Conclusion : The mivacurium-induced neuromuscular blockade is prolonged by the experimental hepatic failure and cholestasis, and the effects may be caused by the hepatic dysfunction, impairment of direct biliary excretion. (Korean J Anesthesiol 1997; 32: 192∼198)