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- 저자 : Garjani, Alireza (검색결과 3 건)
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Severe complications of tramadol overdose in Iran
Paria Habibollahi,Alireza Garjani,Samad Shams Vahdati,Seyyed-Reza Sadat-Ebrahimi,Neda Parnianfard 한국역학회 2019 Epidemiology and Health Vol.41 No.-
OBJECTIVES: Severe complications of tramadol overdose have been reported; however, few large-scale studies have investigated this issue. Therefore, this study aimed to explore the presentation and complications of tramadol overdose in patients admitted to an intoxication referral center in northwestern Iran. METHODS: Patients with tramadol overdose admitted to Sina Teaching Hospital in Tabriz, Iran during 2013-2017 were included. For each patient, the following data were collected: demographics, previous drug or medication overdose, whether the patient was in the process of quitting drug use, ingested dose of tramadol and co-ingestants, Glasgow Coma Scale (GCS) score, clinical symptoms at the time of admission, and admission characteristics. Serotonin toxicity was diagnosed in patients who fit the Hunter criteria. Multiple logistic regression was performed to identify variables associated with the incidence of severe complications of tramadol overdose. RESULTS: In total, 512 cases of tramadol overdose were evaluated, of which 359 patients were included, with a median age of 41 years (range, 16-69) and a median tramadol dose of 1,500 mg (range, 500-4,000). The most frequent complications associated with tramadol overdose were hypertension (38.4%), tachycardia (24.8%), and seizure (14.5%). No serotonin toxicity was detected in patients. Having a GCS score <15, having taken a tramadol dose of >1,000 mg, being in the process of quitting drug use, being 30-49 years old, and male sex were significantly related to the incidence of severe complications of tramadol overdose. CONCLUSIONS: Although seizure was prevalent among Iranian patients with tramadol poisoning, serotonin toxicity and cardiogenic shock were rare findings.
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Antinociceptive Properties of Extracts and Two Flavonoids Isolated from Leaves of Danae racemosa
Maleki-Dizaji, Nasrin,Fathiazad, Fatemeh,Garjani, Alireza 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12
The antinociceptive properties of the hydro-methanolic extract (HME) and two flavonoids isolated from Danae racemosa have been investigated in several nociceptive rat models. The HME from D. racemosa $(100-400mgkg^{-1},\;i.p.)$ produced significant dose-related inhibition of acetic acid-induced abdominal constriction. In the same dose range, the HME produced dose-related inhibition in both phases of a formalin-test. Treatment of animals with naloxone $(5mgkg^{-1},\;i.p.)$ completely reversed the antinociceptive effect caused by morphine $(5mgkg^{-1},\;s.c.)$ and the HME $(200mgkg^{-1},\;i.p.)$ when assessed against the first phase of the formalin-test, but this effect was less significant for the HME in the second phase. Furthermore, when assessed via a hot-plate test, the HME $(100-400mgkg^{-1},\;i.p.)$ caused a significant increase in response latency. The HME, given daily for to 7 consecutive days, develop tolerance, but did not induce cross-tolerance to morphine. These data demonstrate that the HME elicites pronounced antinociception against several pain models. The actions of the HME involve, at least in part, an interaction with the opioid system, but does not seem to be related with non-specific peripheral or central depressant actions. Finally, the active principle(s) responsible for the antinociceptive action of D. racemosa is likely to be partially related to the presence of quercetin and kaempferol.
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Antinociceptive Properties of Extracts and Two Flavonoids Isolated from Leaves of Danae racemosa
Nasrin Maleki-Dizaji,Fatemeh Fathiazad,Alireza Garjani 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12
The antinociceptive properties of the hydro-methanolic extract (HME) and two flavonoids isolated from Danae racemosa have been investigated in several nociceptive rat models. The HME from D. racemosa (100-400 mgkg-1, i.p.) produced significant dose-related inhibition of acetic acid-induced abdominal constriction. In the same dose range, the HME produced doserelated inhibition in both phases of a formalin-test. Treatment of animals with naloxone (5 mgkg-1, i.p.) completely reversed the antinociceptive effect caused by morphine (5 mgkg-1, s.c.) and the HME (200 mgkg-1, i.p.) when assessed against the first phase of the formalin-test, but this effect was less significant for the HME in the second phase. Furthermore, when assessed via a hot-plate test, the HME (100-400 mgkg-1, i.p.) caused a significant increase in response latency. The HME, given daily for to 7 consecutive days, develop tolerance, but did not induce cross-tolerance to morphine. These data demonstrate that the HME elicites pronounced antinociception against several pain models. The actions of the HME involve, at least in part, an interaction with the opioid system, but does not seem to be related with non-specific peripheral or central depressant actions. Finally, the active principle(s) responsible for the antinociceptive action of D. racemosa is likely to be partially related to the presence of quercetin and kaempferol.
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