Enhanced thermal-mechanical properties of rolled tungsten bulk material reinforced by in situ nanosized Y–Zr–O particles

Yao Gang,Chen Hong-Yu,Luo Lai-Ma,Zan Xiang,Wu Yu-Cheng 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.6

Tungsten is the most promising plasma facing material for fusion reactors. Rolled W–Y2(Zr)O3 bulk material has been successfully produced in this study for future fusion engineering applications. The introduction of Zr is conducive to the refinement of the second phase particles. Nano-sized Y–Zr–O particles are observed in the powder and bulk samples. Related results show that the Y–Zr–O particle dispersion distribution improves the heat load resistance of W–Y2(Zr)O3 composite material. For four-point bend experiments in the same sampling direction, the DBTT of W–Y2(Zr)O3 composite materials is lower compared to the pure tungsten. For the same material, the DBTT of the material was selected for testing along the RD direction is lower compared to the material was selected for testing along the TD direction. Findings of this study provide suggestions for the subsequent industrial preparation of nanoscale particle-doped tungsten materials

Different segregation effects for Sc and Ce in an Al/δ´ interface

Yao Jian-Gang,Jiang Yong,Yin Deng-Feng 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.78 No.8

The behaviors of Sc and Ce segregation at Al (100)/δ´(100), Al (110)/δ´(110), and Al (111)/δ´(111) interfaces were theoretically predicted to explore the differences in the segregation effects in Al–Li alloys. The results show that Sc exhibits an evident trend to segregation to the Al/δ´ interface whereas this effect for Ce seems to be weak. The variation of the segregation energy is associated with the different orientation of the corresponding interface. The preferable segregated site is on the Al matrix side where the solutes tend to substitute the Al atom at the Li site for the first layer of the corresponding interface.

Correlation of the size and shape of the solid particles in synovial fluid and knee joint disease

Zhen-Gang Zha,Cheng-Can Yao,Mei Tu,Yao-Xiong Huang 한국물리학회 2007 Current Applied Physics Vol.7 No.s1

The shape and size of solid particles and their distribution in synovial uid were observed and determined as functions of knee jointdiseases by using a multi-dimensional microscope. The results show that there is a close correlation between them, so that the measurement of the parameters might offer a reliable method for diagnosing joint diseases at an early stage and their prognosis.

RON and MET Co-overexpression Are Significant Pathological Characteristics of Poor Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer

Tian-Hao Weng,Min-Ya Yao,Xiang-Ming Xu,Chen-Yu Hu,Shu-Hao Yao,Yi-Zhi Liu,Zhi-Gang Wu,Tao-Ming Tang,Pei-Fen Fu,Ming-Hai Wang,Hang-Ping Yao 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3

Purpose Triple-negative breast cancer (TNBC) is highly malignant and has poor prognosis and a high mortality rate. The lack of effective therapy has spurred our investigation of new targets for treating this malignant cancer. Here, we identified RON (macrophage-stimulating 1 receptor) and MET (MET proto-oncogene, receptor tyrosine kinase) as a prognostic biomarker and therapeutic targets for potential TNBC treatment. Materials and Methods We analyzed RON and MET expression in 187 primary TNBC clinical samples with immunohistochemistry. We validated the targeted therapeutic effects of RON and MET in TNBC using three tyrosine kinase inhibitors (TKIs): BMS-777607, INCB28060, and tivantinib. The preclinical therapeutic efficacy of the TKIs was mainly estimated using a TNBC xenograft model. Results Patients with TNBC had widespread, abnormal expression of RON and MET. There was RON overexpression, MET overexpression, and RON and MET co-overexpression in 63 (33.7%), 63 (33.7%), and 43 cases (23.0%), respectively, which had poor prognosis and short survival. In vivo, the TKI targeting RON ant MET inhibited the activation of the downstream signaling molecules, inhibited TNBC cell migration and proliferation, and increased TNBC cell apoptosis; in the xenograft model, they significantly inhibited tumor growth and shrank tumor volumes. The TKI targeting RON and Met, such as BMS-777607 and tivantinib, yielded stronger anti-tumor effects than INCB28060. Conclusion RON and MET co-overexpression can be significant pathological characteristics in TNBC for poor prognosis. TKIs targeting RON and MET have stronger drug development potential for treating TNBC.

A reverse transcription loop-mediated isothermal amplification assay to rapidly diagnose foot-and-mouth disease virus C

Yao-zhong Ding,Jian-hua Zhou,Li-na Ma,Yan-ni Qi,Gang Wei,Jie Zhang,Yong-guang Zhang 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.3

A reverse transcription loop-mediated isothermalamplification (RT-LAMP) assay was developed to rapidlydetect foot-and-mouth disease virus serotype C (FMDV C). By testing 10-fold serial dilutions of FMDV C samples,sensitivity of the FMDV C RT-LAMP was found to be 10times higher than that of conventional reverse transcription-PCR (RT-PCR). No cross-reactivity with A, Asia 1, or OFMDV or swine vesicular disease virus (SVDV) indicatedthat FMDV C RT-LAMP may be an exciting novel method for detecting FMDV C.

Volatile Compounds of Orange Wines Produced with and without Peel Contact

Gang Fan,Xiaolin Yao,Yongxia Xu,Huanhuan Li,Hongfei Fu,Kexing Wang,Siyi Pan 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.6

The present study focused on the effects of peel contact on the volatile compounds of orange wines. The volatile compounds were analyzed by sensory and instrumental analyses. Solid-phase microextraction (SPME) was used for extraction of volatile compounds. A total of 19 and 27 volatile compounds were identified in without and with peel contact wines respectively. Esters were quantitatively the dominant group of volatile compounds in without peel contact wines, while terpenes were the most abundant compounds in peel contact wines. Totally 11 and 14 new formed compounds were found in without and with peel contact wines, mainly were esters, alcohols, and acids. According to sensory analysis, the peel contact wine showed a more citrus-like and fruity aroma than the wines without peel contact.

Behavior of composite box bridge girders under localized fire exposure conditions

Gang Zhang,Venkatesh Kodur,Weifa Yao,Qiao Huang 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.69 No.2

This paper presents results from experimental and numerical studies on the response of steel-concrete composite box bridge girders under certain localized fire exposure conditions. Two composite box bridge girders, a simply supported girder and a continuous girder respectively, were tested under simultaneous loading and fire exposure. The simply supported girder was exposed to fire over 40% of its span length in the middle zone, and the two-span continuous girder was exposed to fire over 38% of its length of the first span and full length of the second span. A measurement method based on comparative rate of deflection was provided to predict the failure time in the hogging moment zone of continuous composite box bridge girders under certain localized fire exposure condition. Parameters including transverse and longitudinal stiffeners and fire scenarios were introduced to investigate fire resistance of the composite box bridge girders. Test results show that failure of the simply supported girder is governed by the deflection limit state, whereas failure of the continuous girder occurs through bending buckling of the web and bottom slab in the hogging moment zone. Deflection based criterion may not be reliable in evaluating failure of continuous composite box bridge girder under certain fire exposure condition. The fire resistance (failure time) of the continuous girder is higher than that of the simply supported girder. Data from fire tests is successfully utilized to validate a finite element based numerical model for further investigating the response of composite box bridge girders exposed to localized fire. Results from numerical analysis show that fire resistance of composite box bridge girders can be highly influenced by the spacing of longitudinal stiffeners and fire severity. The continuous composite box bridge girder with closer longitudinal stiffeners has better fire resistance than the simply composite box bridge girder. It is concluded that the fire resistance of continuous composite box bridge girders can be significantly enhanced by preventing the hogging moment zone from exposure to fire. Longitudinal stiffeners with closer spacing can enhance fire resistance of composite box bridge girders. The increase of transverse stiffeners has no significant effect on fire resistance of composite box bridge girders.

Effects of Castration on Androgen Receptor, IGF-I Ea, MGF and Myostatin Gene Expression in Skeletal Muscles of Male Pigs

Yao, Yuchang,Cai, Zhaowei,Zhang, Lifan,Zhao, Chunjiang,Wu, Keliang,Xu, Ningying,Liu, Gang,Wu, Changxin Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.8

Castration of male pig produces significant negative effects on skeletal muscle development. The androgen receptor (AR), two splice variants of insulin-like growth factor-I (IGF-I Ea and MGF) and the myostatin gene may play important roles in this process. In the present study, the expression of AR, IGF-I Ea, MGF and myostatin genes in three skeletal muscles, the brachialis, longissimus and semitendinosus, were studied using real-time quantitative RT-PCR. Our experimental design used 14 pairs of male Landrace sire${\times}$Yorkshire dam piglets. The two piglets in each pair were full sibs, one of which was castrated at 21 d of age; the other remained intact. The study group was divided into subgroups of equal size. Animals in the first subgroup were slaughtered at 147 d and those of the second at 210 d of age. Carcass weight and lean meat yield were similar between boars and barrows at 147 d of age (p>0.05), whereas barrows had lower carcass weight and less lean meat yield at 210 d of age (p<0.05). Castration caused down-regulation of AR gene expression at both 147 and 210 d of age (p<0.05). The two splice variants of the IGF-I gene from porcine skeletal muscle were cloned using RT-PCR, and it was found that MGF differs from IGF-I Ea in having a 52-base insert in the last coding exon of the mRNA. Both splice variants were down-regulated by castration only at 210 d of age (p<0.05). No differences in expression of the myostatin gene were observed between boars and barrows at either 147 or 210 d of age (p>0.05). These results suggest that the downregulation of AR, IGF-I Ea and MGF gene expression following castration helps to explain the negative effect of castration on skeletal muscle development.

Synthesis and characterization of polypyrrole doped by cage silsesquioxane with carboxyl groups

Gang Shi,Youxin Che,Luyan Wu,Yao Rong,Caihua Ni 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.2

Cage silsesquioxane with carboxyl groups (POSS-COOH) was successfully synthesized, after which it was added to polypyrrole (PPy) as a dopant to produce the doped PPy (PPy/POSS-COOH) solution. The PPy/POSSCOOH composites were characterized by FTIR (Fourier transformation infrared spectroscopy), SEM (Scanning electron microscopy), TGA (Thermo-gravimetric analysis), CV (Cyclic voltammetry) and RL (Reflection loss). Compared to PPy without POSS-COOH (un-PPy), the conductivity of PPy/POSS-COOH composites could be improved dramatically, reaching up to 0.850 S/cm at 25 oC. Under N2 atmosphere, the residual rate of PPy/POSS-COOH was 68% at 700 oC, 14% higher than the one of un-PPy. Meanwhile, PPy/POSS-COOH had a reflection loss below −8 dB over 9.35 to 11.20GHz, with a minimum value of −10.32 dB at 10.54 GHz, thus demonstrating higher microwave absorption than un-PPy. This method may provide a facile route to produce doped conducting polymers with POSS-COOH.

Suppression of MED19 expression by shRNA induces inhibition of cell proliferation and tumorigenesis in human prostate cancer cells

( Xin Gang Cui ),( Dan Feng Xu ),( Chao Lv ),( Fa Jun Qu ),( Jin He ),( Ming Chen ),( Yu Shan Liu ),( Yi Gao ),( Jian Ping Che ),( Ya Cheng Yao ),( Hong Yu Yu ) 생화학분자생물학회 2011 BMB Reports Vol.44 No.8

MED19 is a member of the Mediator that plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas. To tested the functional role of MED19 in human prostate cancer, we downregulated MED19 expression in prostate cancer cells (PC-3 and DU145) by lentivirus- mediated short hairpin (shRNA), and analyzed the effect of inhibition of MED19 on prostate cancer cell proliferation and tumorigenesis. The in vitro prostate cancer cell proliferation, colony formation, and in vivo tumor growth in nude mice xenografts was significantly reduced after the downregulation of MED19. Knock- down of MED19 caused S-phase arrest and induced apoptosis via modulation of Bid and Caspase 7. It was suggested that MED19 serves as a novel proliferation regulator that promotes growth of prostate cancer cells. [BMB reports 2011; 44(8): 547-552]