Trisomy 12p Syndrome Secondary to a Balanced Maternal Translocation [46,XX, t(12;22)(p11.2;p13)]

( Mi Hyeon Gang ),( Yong Wook Lee ),( Han Hyuk Lim ),( Mea-young Chang ) 대한주산의학회 2019 Perinatology Vol.30 No.4

Trisomy 12p is a rare chromosomal anomaly. It causes dysmorphic features, multiple congenital anomalies, neonatal complications, and mental retardation. We present a case of complete and pure trisomy 12p syndrome resulting from malsegregation of a balanced translocation of maternal origin, with a comprehensive literature review.

Leri-Weill dyschondrosteosis in a newborn presenting with respiratory failure due to severe micrognathia

Mi Hyeon Gang,Jianne Lee,Yong Wook Lee,Ji Hye Shin,Han Hyuk Lim,Yoo-Mi Kim,Mea-young Chang 대한의학유전학회 2020 대한의학유전학회지 Vol.17 No.2

Short stature homeobox-containing gene (SHOX) is a well-known causative gene for the short stature in Turner syndrome. The clinical manifestation of SHOX gene related disorders varies from SHOX haploinsufficiency, presenting with idiopathic short stature, disproportionate short stature, or Leri-Weill dyschondrosteosis (LWD) to recessive form of extreme dwarfism and limb deformity in Langer mesomelic dysplasia. LWD is usually diagnosed upon suspicion based on short stature and skeletal abnormalities, and it is rarely accompanied with respiratory failure in the neonatal period. Here, we report the case of a newborn infant with LWD presenting with severe micrognathia that caused respiratory distress, which was diagnosed using microarray testing. Even when the manifestation of Madelung deformity is not yet apparent, LWD should be considered as one of underlying diseases related to congenital micrognathia.

Breast Milk-Transmitted Cytomegalovirus Infection in Preterm Infants

Mi Hyeon Gang,장미영 대한신생아학회 2018 Neonatal medicine Vol.25 No.2

Purpose: The purpose of this study is to describe the rate of cytomegalovirus (CMV) virolactia, and the prevalence of breast milk (BM)-transmitted postnatal CMV infection among premature infants after freeze-thawing (FT) and Holder pasteurization (HP) of breast milk. Methods: This is a single-center, retrospective study of 312 infants born at less than 32 weeks of gestation, or with a birth weight less than 1,500 g from January 2013 to June 2017. All infants were screened for CMV-specific immunoglobulin (Ig) G and IgM at birth. Initial CMV specific polymerase chain reaction (PCR) and CMV culture were performed on mothers’ BM and babies’ urine within the first 21 days of life. FT and HP of BM was used to prevent the transmission of CMV. For the surveillance of postnatal CMV infection, CMV culture and CMV specific PCR of urine from babies were repeated one to two months after the initial screening. Screening for viremia and viruria was performed if postnatal CMV infection was suspected. Results: Among 178 BM samples obtained from mothers of CMV-IgG-seropositive infants, 80 (44.9%) were CMV PCR positive. CMV deoxyribonucleic acid (DNA) was detected in five of the 22 BM samples (22.7%) obtained from the mothers of CMV-IgG seronegative infants. When CMV DNA load in BM was measured before and after HP, various results were shown. Sixty-three infants out of 232 (27.2%) were evaluated for postnatal CMV infection and four infants out of 63 (6.3%) were infected. Conclusion: Interventions to prevent BM-transmitted CMV infection can reduce the chance of postnatal CMV infection, but not completely eliminate it.

Successful Management of Visceral Kaposiform Hemangioendothelioma with Kasabach‐Merritt Phenomenon Using Corticosteroids and Vincristine

Mi Hyeon Gang,임연정,장미영 대한신생아학회 2020 Neonatal medicine Vol.27 No.1

Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular neoplasm that often develops a coagulopathy known as Kasabach-Merritt phenomenon (KMP). Visceral involvement denotes a poor prognosis. We report a case of visceral KHE with KMP successfully treated with corticosteroids and vincristine. The infant had been born vaginally at 34 weeks 6 days’ gestation, weighing 2,360 g. He was admitted for the management of respiratory failure. Blood tests showed anemia and thrombocytopenia 1 hour after delivery. Additional blood tests revealed a prothrombin time of 12.1 seconds, activated partial thromboplastin time of 60.6 seconds, fibrinogen levels of 72.4 mg/dL, and D-dimer levels >3,200 ng/mL. Despite supportive measures and daily transfusions, the clinical condition and coagulopathy gradually worsened. Renal ultrasonography performed to find the origin of the coagulopathy revealed an echogenic mass measuring >3 cm in the abdominal cavity. A magnetic resonance imaging scan showed an ill-marginated, infiltrative mass like lesion in the right anteromedial and posteromedial perirenal space that was hypointense with mild enhancement on T1- and T2-weighted images. Large vascular tumors adherent to other visceral organs were noted during exploratory laparotomy but could not be resected. Treatment with methylprednisolone was ineffective. Vincristine was administered weekly from the 17th hospital day, and the coagulation profile showed gradual improvement after its initiation. Intravenous methylprednisolone was switched to oral prednisolone on the 57th hospital day. He was discharged on the 73rd hospital day and continued vincristine treatment every 2 weeks and oral prednisolone administration as an outpatient treatment for 8 weeks. He remained symptom-free at the 39-month follow-up.

Secondary renal tubular dysgenesis in a newborn exposed to angiotensin II receptor antagonist during gestation

Gang, Mi Hyeon,Lee, Yong Wook,Chang, Mea-young The Korean Pediatric Society 2021 Clinical and Experimental Pediatrics (CEP) Vol.64 No.3

Short-Term Complications of Percutaneous Endoscopic Gastrostomy according to the Type of Technique

Gang, Mi Hyeon,Kim, Jae Young The Korean Society of Pediatric Gastroenterology 2014 Pediatric gastroenterology, hepatology & nutrition Vol.17 No.4

Purpose: The method of percutaneous endoscopic gastrostomy (PEG) tube placement can be divided into the pull and introducer techniques. We compared short-term complications and prognosis between patients who underwent the pull technique and two other types of introducer techniques, the trocar introducer technique and T-fastener gastropexy technique. Methods: Twenty-six patients who underwent PEG were enrolled in this study. We retrospectively investigated the age, sex, body weight, weight-for-age Z-score, underlying diseases, PEG indications, complications, duration of NPO (nil per os), pain control frequency, and duration of antibiotic therapy. The patients were classified into three groups according to the PEG technique. The occurrence of complications was monitored for 10 weeks after the procedure. Results: The age, sex, body weight, and weight-for-age Z-score were not significantly between the three groups. Most patients had cerebral palsy and seizure disorders. Dysphagia was the most common indication for PEG. Major complications occurred in 5 (50%), 4 (66.7%), and 0 (0%) patients in group I, II, and III, respectively (p=0.005). Further, peristomal infection requiring systemic antibiotic therapy occurred in 2 (20%), 3 (50%), and 0 (0%) patients in group I, II, and III, respectively (p=0.04). There was no significant difference between the groups with respect to minor complications, duration of NPO, pain control frequency, and duration of antibiotic therapy. Conclusion: The results indicate that the T-fastener gastropexy technique was associated with the lowest rate of major complications.

Enhancement of Seed Germination and Seedling Growth of Allium victorialis var. platyphyllum by the Soaking Treatment of Plant Growth Regulators

Mi Jin Jeong,Hyun Jin Song,Seon Jeong Sim,Yeong Rong Seo,Hyeon Jeong Im,Gang Uk Suh,Chandrakant. S. Karigar,Myung Suk Choi 경상대학교 농업생명과학연구원 2015 농업생명과학연구 Vol.49 No.1

The effects of seed soaking treatment with the solutions of plant growth regulators IAA, GA3 and BAP on seed germination and shoot and bulb growth of Allium victorialis var. platyphyllum (Korean wild garlic) were determined. A significant variation in the seed germination rate was recorded at all treatments for various soaking periods. Maximum seed germination was obtained when seeds were soaked in IAA or GA3 solution at 200 mg L-1. The MAP treated seeds started to germinate after 3 months. Among treatments, IAA was found to be most effective in improving seed germination, but further seedling growth was not correlated to the soaking time. Seed soaking in IAA or GA3 solution enhanced further growth of seedlings compared with water control treatment. Shoot and bulb growth was highest in GA3 treatments.

Control of Electronic Structure of Graphene by Various Dopants and Their Effects on a Nanogenerator

Shin, Hyeon-Jin,Choi, Won Mook,Choi, Dukhyun,Han, Gang Hee,Yoon, Seon-Mi,Park, Hyun-Kyu,Kim, Sang-Woo,Jin, Yong Wan,Lee, Sang Yoon,Kim, Jong Min,Choi, Jae-Young,Lee, Young Hee American Chemical Society 2010 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.132 No.44

<P>It is essential to control the electronic structure of graphene in order to apply graphene films for use in electrodes. We have introduced chemical dopants that modulate the electronic properties of few-layer graphene films synthesized by chemical vapor deposition. The work function, sheet carrier density, mobility, and sheet resistance of these films were systematically modulated by the reduction potential values of dopants. We further demonstrated that the power generation of a nanogenerator was strongly influenced by the choice of a graphene electrode with a modified work function. The off-current was well quenched in graphene films with high work functions (Au-doped) due to the formation of high Schottky barrier heights, whereas leakage current was observed in graphene films with low work functions (viologen-doped), due to nearly ohmic contact.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2010/jacsat.2010.132.issue-44/ja105140e/production/images/medium/ja-2010-05140e_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja105140e'>ACS Electronic Supporting Info</A></P>

자생지 우점수종의 산마늘 발아 및 유묘 생장에 미치는 잠재적 알렐로파시 효과

정미진 ( Mi Jin Jeong ),송현진 ( Hyun Jin Song ),김학곤 ( Hak Gon Kim ),서영롱 ( Yeong Rong Seo ),임현정 ( Hyeon Jeong Im ),서강욱 ( Gang Uk Suh ),최명석 ( Myung Suk Choi ) 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-

알렐로파시 효과 구명을 위해 수종은 울릉도 산마늘 자생지의 우점종인 너도밤나무, 우산고로쇠를 내륙지역 산마늘 자생지 우점종인 신갈나무, 그리고 내륙지역 산지에 가장 많이 분포하는 소나무와 잣나무에 대해 산마늘 종자발아와 실생묘의 생장에 미치는 영향을 조사하였다. 각 수종의 잎을 산마늘종자의 발아율 및 생장을 측정하기 위해 낙엽처리, 분쇄잎 처리, 그리고 냉·열수 추출물을 각각 처리하였다. 그 결과, 낙엽처리에서는 53~58%로 상대적으로 발아율이 높았고, 분쇄된 잎을 인공토와 섞어처리하였을 때 산마늘의 발아력이 가장 낮게 나타났다. 수종 중에서는 소나무 처리구가 가장 산마늘의 발아율을 억제시켰으며, 지상부 생장에도 부정적인 영향을 주었다. 냉·열수 추출물을 다른 농도로 처리하였을 때 5% 소나무 추출물이 산마늘 종자의 발아를 가장 억제하였고, 전체적으로 냉수추출에서는 침엽수인 소나무와 잣나무 처리에서 낮은 발아를 보였다. 자생지 우점종인 너도밤나무 처리는 산마늘종자의 발아와 실생묘 생장에 큰 영향을 주지 않았지만, 열수추출된 활엽수 추출물은 산마늘의 종자발아와 실생묘 생장에 부정적인 영향을 주었다. Allelopathic effect of a dominant tree species on A. victorialis var. platyphyllum habitat were investigated using fallen, grinded leaves and aqueous extracts. Fallen leaves showed germination percentage in 53~58%. Seed germination on grinded leaves was inhibited significantly compared to fallen leaves feeding. Fallen leaves of Pinus densiflora were significantly inhibited on seedling growth compared to other tree species. Root growth of seedling was inhibited in 3g treatment of Acer okamotoanum, P. densiflora and Pinus koraiensis fallen leaves. P. densiflora and P. koraiensis in inland area inhibited the seed germination and seedling growth which indicates that plants may possible allelopathic activity. Cold and hot aqueous extracts of 5 tree species caused a reduction in germination percent, seedling vigour index. Tolerance index was significantly low as 5.0% in 5% extract of P. densiflora and exhibited unique pattern on seed germination according to deciduous or conifer tree. Cold aqueous extracts of the P. densiflora revealed the strong inhibitory effect on germination, with hot aqueous extracts of deciduous trees exhibiting lower germination percentage.

The Characteristics of the Appearance and Health Risks of Volatile Organic Compounds in Industrial (Pohang, Ulsan) and Non-Industrial (Gyeongju) Areas

Jong-Hyeon Jung,Bong-Wook Choi,Mi-Hyun Kim,Sung-Ok Baek,Gang-Woo Lee,Byung-Hyun Shon 환경독성보건학회 2012 환경독성보건학회지 Vol.27 No.-

Objectives: The aim of this study was to identify the health and environmental risk factors of air contaminants that influence environmental and respiratory diseases in Gyeongju, Pohang and Ulsan in South Korea, with a focus on volatile organic compounds (VOCs). Methods: Samples were collected by instantaneous negative pressure by opening the injection valve in the canister at a fixed height of 1 to 1.5 m. The sample that was condensed in -150℃ was heated to 180℃ in sample pre-concentration trap using a 6-port switching valve and it was injected to a gas chromatography column. The injection quantity of samples was precisely controlled using an electronic flow controller equipped in the gas chromatography-mass spectrometer. Results: The quantity of the VOC emissions in the industrial area was 1.5 to 2 times higher than that in the non-industrial area. With regards to the aromatic hydrocarbons, toluene was detected at the highest level of 22.01 ppb in Ulsan, and chloroform was the halogenated hydrocarbons with the highest level of 10.19 ppb in Pohang. The emission of toluene was shown to be very important, as it accounted for more than 30% of the total aromatic hydrocarbon concentration. Conclusions: It was considered that benzene in terms of the cancer-causing grade standard, toluene in terms of the emission quantity, and chloroform and styrene in terms of their grades and emission quantities should be selected for priority measurement substances.