Hemorheological parameters in coronary artery disease detected by multi-slice CT

Toth, Andras,Szukits, Sandor,Varady, Edit,Sandor, Barbara,Rabai, Miklos,Papp, Judit,Juricskay, Istvan,Kesmarky, Gabor,Toth, Kalman,Sumegi, Balazs,Battyani, Istvan 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2

Epidemiological studies have confirmed that hemorheological parameters are primary risk factors in CAD; and their alterations in CAD have been described. We aimed to investigate both macro- and microrheological properties of blood in patients with CAD. The data of 121 patients (mean age: $58.8{\pm}9.6$ years) undergoing coronary CT were analyzed. Blood samples were obtained right before CT examinations. Hematocrit (Hct), plasma (PV) and apparent whole blood viscosity (WBV), red blood cell (RBC) aggregation and RBC deformability were measured. Patients were classified into four groups according to their coronary vessel state: Negative group (n = 32, mean age: $56.8{\pm}11.1$ years) without any coronary stenosis or atherosclerotic lesion and zero calcium-score, Non-significant group (n = 27, mean age: $59.2{\pm}7.5$ years) below 40% area stenosis, Single-vessel group (n = 32, mean age: $58.8{\pm}8.5$ years) over 40% area stenosis or history of PCI or CABG on one coronary vessel, Multi-vessel group (n = 30, mean age: $62.1{\pm}8.4$ years) with over 40% area stenosis or history of PCI or CABG on multiple coronary vessels. Hct was significantly (p < 0.05) higher in all CAD (Non-significant, Single-vessel, Multi-vessel) groups compared to the Negative group. WBV was significantly (p<0.05) higher in the Multi-vessel group compared to the Negative group. No significant ($p{\geq}0.05$) differences were observed in PV. RBC aggregation was significantly (p < 0.05) increased in the Multi-vessel group compared to the Negative group. RBC deformability showed a decreasing tendency with the increasing number of atherosclerotic vessels. Our results indicate that hemorheological variables are deteriorated in patients with CAD established by coronary CT, which is more pronounced in severe coronary disease.

Hemorheological parameters in coronary artery disease detected by multi-slice CT

Andras Toth,Sandor Szukits,Edit Varady,Barbara Sandor,Miklos Rabai,Judit Papp,Istvan Juricskay,Gabor Kesmarky,Kalman Toth,Balazs Sumegi,Istvan Battyani 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2

Epidemiological studies have confirmed that hemorheological parameters are primary risk factors in CAD;and their alterations in CAD have been described. We aimed to investigate both macro- and microrheologicalproperties of blood in patients with CAD. The data of 121 patients (mean age: 58.8 ± 9.6 years) undergoingcoronary CT were analyzed. Blood samples were obtained right before CT examinations. Hematocrit (Hct),plasma (PV) and apparent whole blood viscosity (WBV), red blood cell (RBC) aggregation and RBC deformabilitywere measured. Patients were classified into four groups according to their coronary vessel state: Negativegroup (n = 32, mean age: 56.8 ± 11.1 years) without any coronary stenosis or atherosclerotic lesion andzero calcium-score, Non-significant group (n = 27, mean age: 59.2 ± 7.5 years) below 40% area stenosis, Single-vessel group (n = 32, mean age: 58.8 ± 8.5 years) over 40% area stenosis or history of PCI or CABG onone coronary vessel, Multi-vessel group (n = 30, mean age: 62.1 ± 8.4 years) with over 40% area stenosis orhistory of PCI or CABG on multiple coronary vessels. Hct was significantly (p < 0.05) higher in all CAD(Non-significant, Single-vessel, Multi-vessel) groups compared to the Negative group. WBV was significantly(p<0.05) higher in the Multi-vessel group compared to the Negative group. No significant (p ≥ 0.05) differenceswere observed in PV. RBC aggregation was significantly (p < 0.05) increased in the Multi-vesselgroup compared to the Negative group. RBC deformability showed a decreasing tendency with the increasingnumber of atherosclerotic vessels. Our results indicate that hemorheological variables are deteriorated inpatients with CAD established by coronary CT, which is more pronounced in severe coronary disease.

THE AKARI FIS CATALOGUE OF YSOS AND EXTRAGALACTIC OBJECTS

L. Viktor Toth,GABOR MARTON,SAROLTA ZAHORECZ,LAJOS G. BALAZS,ANDREA NAGY 한국천문학회 2017 天文學論叢 Vol.32 No.1

The point sources in the Bright Source Catalogue of the \textit{AKARI} Far-Infrared Surveyor (FIS) were classified based on their FIR and mid-IR fluxes and colours into young stellar object (YSO) and extragalactic source types using a Quadratic Discriminant Analysis method (QDA) and Support Vector Machines (SVM). The reliability of the selection of YSO candidates is high, and the number of known YSO candidates were increased significantly, that we demonstrate in the case of the nearby open cluster {IC348}. Our results show that we can separate galactic and extragalactic \textit{AKARI} point sources in the multidimensioal space of FIR fluxes and colours with high reliability, however, differentiating among the extragalactic sub-types needs further information.

In vitro hemorheological effects of parenteral agents used in peripheral arterial disease

Biro, Katalin,Sandor, Barbara,Toth, Andras,Koltai, Katalin,Papp, Judit,Rabai, Miklos,Toth, Kalman,Kesmarky, Gabor 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2

Peripheral arterial disease (PAD) is a frequent manifestation of systemic atherosclerosis. In PAD hemorheological parameters were defined as risk factors in a number of studies and several therapeutic agents were tried in these conditions. Our study aims to investigate and compare the in vitro hemorheological effects of various drugs generally used in the parenteral treatment of intermittent claudication and critical limb ischemia. Blood samples of healthy male volunteers were incubated with iloprost, alprostadil, pentoxifylline, sulodexide or pentosan polysulfate at calculated therapeutic serum concentration. Hematocrit (Hct) was determined by microhematocrit centrifuge. Plasma and apparent whole blood viscosities (WBV) were evaluated by capillary viscometer. Red blood cell aggregation was measured by LORCA (laserassisted optical rotational cell analyzer) aggregometer, and LORCA ektacytometer was used for measuring erythrocyte deformability at $37^{\circ}C$. Iloprost, alprostadil, and pentoxifylline incubation did not have any significant effect on plasma and apparent WBV. Elongation index increased in samples incubated with alprostadil at low shear stresses 0.95 and 0.53 Pa (p < 0.05). Sulodexide significantly improved WBV and Hct/WBV ratio (p < 0.05). Incubation with pentosan polysulfate resulted in higher WBV, lower Hct/WBV ratio and deterioration in the aggregation parameters (p < 0.05). Sulodexide may have beneficial effect on a macrorheological parameter; alprostadil may improve a microrheological parameter. Hemorheological alterations could be important in PAD patients with hampered vasodilator capacity.

Initial Experience Using the 5MAX™ ACE Reperfusion Catheter in Intra-arterial Therapy for Acute Ischemic Stroke

Seby John,Muhammad S. Hussain,Gabor Toth,Mark Bain,Ken Uchino,Ferdinand K. Hui 대한뇌혈관외과학회 2014 Journal of Cerebrovascular and Endovascular Neuros Vol.16 No.4

Objectives : The 5MAX ACE is a new large bore aspiration catheter availablefor vessel recanalization for treatment of acute ischemic stroke (AIS). We report our initial experience with its use. Methods : A retrospective analysis of patients undergoing intra-arterialtherapy for AIS using the 5MAX ACE reperfusion catheter at our institutionwas performed. Patient demographics, clinical characteristics andprocedural data were obtained from chart review. Successful recanlizationwas defined as achievement of Thrombolysis in Cerebral Infarction score(TICI) 2b-3 and time to recanalization was defined as time from groinpuncture to achievement of at least TICI 2b recanalization. Results : The 5MAX ACE was used in 15 patients from July-October2013. Direct aspiration was used as the primary technique in 10/15(67%) patients. Out of these, aspiration alone was sufficient for recanalizationin 3 (20%) patients. In the remaining 7 (47%) patients, additionaldevices were used. In 5/15 (33%) patients, combined aspiration/stentrieverthrombectomy using Solitaire™ (3/5 patients) and Penumbra 3DSeparator™ (2/5 patients) were used as the primary technique. Successfulrecanlization (TICI 2b-3) was achieved in 11/15 (73%) patients. Averagetime from groin puncture to successful recanalization was 46 +/- 30 minutes(range 14-98 minutes). There were no procedural complications. Conclusion : The 5MAX ACE is a useful recanalization tool, either by directaspiration or combined stentriever/aspiration. It may be most advantageouswith large clots in the internal carotid artery. The potentialfor effective and faster recanalization using this device alone or in combinationmay be a good topic for future study.

Seasonal Monitoring of Two Xylophagous Orchard Pests by Pheromone Traps in Bulgaria

Hristina Y. Kutinkova,Mitko Subchev,Miklos Toth,s Gabor Sz?cs,Franco Rama 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

In vitro hemorheological effects of parenteral agents used in peripheral arterial disease

Katalin Biro,Barbara Sandor,Andras Toth,Katalin Koltai,Judit Papp,Miklos Rabai,Kalman Toth,Gabor Kesmarky 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2

Peripheral arterial disease (PAD) is a frequent manifestation of systemic atherosclerosis. In PAD hemorheologicalparameters were defined as risk factors in a number of studies and several therapeutic agents weretried in these conditions. Our study aims to investigate and compare the in vitro hemorheological effectsof various drugs generally used in the parenteral treatment of intermittent claudication and critical limbischemia. Blood samples of healthy male volunteers were incubated with iloprost, alprostadil, pentoxifylline,sulodexide or pentosan polysulfate at calculated therapeutic serum concentration. Hematocrit(Hct) was determined by microhematocrit centrifuge. Plasma and apparent whole blood viscosities (WBV)were evaluated by capillary viscometer. Red blood cell aggregation was measured by LORCA (laserassistedoptical rotational cell analyzer) aggregometer, and LORCA ektacytometer was used for measuringerythrocyte deformability at 37°C. Iloprost, alprostadil, and pentoxifylline incubation did not have any significanteffect on plasma and apparent WBV. Elongation index increased in samples incubated with alprostadilat low shear stresses 0.95 and 0.53 Pa (p < 0.05). Sulodexide significantly improved WBV and Hct/WBV ratio (p < 0.05). Incubation with pentosan polysulfate resulted in higher WBV, lower Hct/WBV ratioand deterioration in the aggregation parameters (p < 0.05). Sulodexide may have beneficial effect on a macrorheologicalparameter; alprostadil may improve a microrheological parameter. Hemorheological alterationscould be important in PAD patients with hampered vasodilator capacity.