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Mitotic protein kinase-driven crosstalk of machineries for mitosis and metastasis
Kim Chang-Hyeon,Kim Da-Eun,Kim Dae-Hoon,Min Ga-Hong,Park Jung-Won,Kim Yeo-Bin,Sung Chang K.,Yim Hyungshin 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Accumulating evidence indicates that mitotic protein kinases are involved in metastatic migration as well as tumorigenesis. Protein kinases and cytoskeletal proteins play a role in the efficient release of metastatic cells from a tumor mass in the tumor microenvironment, in addition to playing roles in mitosis. Mitotic protein kinases, including Polo-like kinase 1 (PLK1) and Aurora kinases, have been shown to be involved in metastasis in addition to cell proliferation and tumorigenesis, depending on the phosphorylation status and cellular context. Although the genetic programs underlying mitosis and metastasis are different, the same protein kinases and cytoskeletal proteins can participate in both mitosis and cell migration/invasion, resulting in migratory tumors. Cytoskeletal remodeling supports several cellular events, including cell division, movement, and migration. Thus, understanding the contributions of cytoskeletal proteins to the processes of cell division and metastatic motility is crucial for developing efficient therapeutic tools to treat cancer metastases. Here, we identify mitotic kinases that function in cancer metastasis as well as tumorigenesis. Several mitotic kinases, namely, PLK1, Aurora kinases, Rho-associated protein kinase 1, and integrin-linked kinase, are considered in this review, as an understanding of the shared machineries between mitosis and metastasis could be helpful for developing new strategies to treat cancer.
Ga Hyeon Kim,Jae Woo Han,Yeong Seok Kim,Yong Ho Choi,Hun Kim,Gyung Ja Choi 한국농약과학회 2021 한국농약과학회 학술발표대회 논문집 Vol.2021 No.11
Erwinia amylovora is a causal agent of fire blight which is the most devastating disease of apple, pear and other rosaceous plants. In the course of developing for new antibiotics to control E. amylovora, we discovered that the culture filtrate of soil bacterium KRICT-B035 exhibits a promising antibacterial activity. The 16S rDNA based phylogenetic analysis revealed that this strain was most closely related to Paenibacillus elgii. Through a series of chromatographic procedures, active compounds were isolated. The ESI-MS and NMR analyses were performed on the purified compounds. In combination with literature data, the chemical structures of active compound were identified pelgipeptins. Pelgipeptins showed the potent antibacterial activity against E. amylovora with minimum inhibitory concentration values ranged from 12.5 to 25μg/ml. These results indicated that pelgipeptins could be used as agricultural antibiotics for fire blight disease control.
Microwave Processing for Recovery of C-14 From Spent Ion Exchange Resin
Ga-Yeong Kim,Ki-Rak Lee,Hwan-Seo Park,Geun-il Park,Hyeon-Oh Park,Gi-Hyeon Kwon 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
Ion exchange resins are commonly employed in the treatment of liquid radioactive waste generated in nuclear power plants (NPP). The ion exchange resin used in NPP is a mixed-bed ion exchange resin known as IRN-150, which is of nuclear grade. This resin is a mixture of cation exchange resin and anion exchange resin. The cation exchange resin removes cationic radionuclides such as Cs and Co, while anion exchange resin handles anions (e.g., H14CO3 -), effectively purifying the liquid waste. Spent ion exchange resins (spent resin) containing C-14 are classified as low and intermediate level radioactive waste, and their radioactivity needs to be reduced as it exceeds the disposal limit regulated by law. Therefore, the microwave technology for the removal of C-14 from spent resin has been investigated. Previous studies have successfully developed a method for the effective removal of C-14 during the resin treatment process. However, it was observed that, in this process, functional groups in the resin were also removed, resulting in the generation of off-gases containing trimethylamine. These off-gases can dissolve in water from process, increasing its pH, which can subsequently hinder the recovery of C-14. In this study, we investigated the high-purity recovery of C-14 by adjusting the moisture content within the reactor following microwave treatment. Mock spent resins, consisting of 100 g of resin with HCO3 - ion-exchanged and 0, 25, or 50 g of deionized water, were subjected to microwave treatment for 40 or 60 minutes. Subsequently, the C-14 desorption efficiency of the mock spent resins was evaluated using an acid stripping process with H3PO4 solution. The functional group status of the mock spent resins was analyzed using 15N NMR spectroscopy. The results showed that the mock spent resins exhibited efficient C-14 recovery without significant functional group degradation. The highest C-14 desorption efficiency was achieved when 25 g of deionized water was used during microwave treatment.
Cutaneous squamous cell carcinoma arising in a patient with neurofibromatosis type 1: a case report
( Ga-hye Na ),( Bo-ra Lim ),( Do-hyeon Kim ),( Soo-hyeon Noh ),( Eun-jung Kim ),( Kun Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
A 31-year-old man with a past history of neurofibromatosis type 1 presented with 2.5x1.5cm sized, exophytic tumor of back covered with crust and oozing. Histopathologic findings were consistent with poor differentiated squamous cell carcinoma. Neurofibromatosis type 1 (NF1) is an autosomal dominant inherited disease. It is known that the incidence of tumors in patients with NF1 is high compared with the normal population. And majority of the tumors are non-epithelial neoplasms, including neurofibromas, malignant peripheral nerve sheath tumors, gliomas and leukemia. Also, some studies have suggested that patients with NF1 also have a significantly higher risk of certain types of carcinomas, including breast cancer. However, the occurrence of cutaneous squamous cell carcinoma in a patient with NF1 is rarely reported and the association between NF1 and cutaneous squamous cell carcinoma is not established. Herein, we report a case of cutaneous squamous cell carcinoma occurring on the back of a 31-year-old man with neurofibromatosis type 1.
Superficial CD34+ fibroblastic tumor on the plantar foot
( Hyeon Jeong Park ),( Kyu Yeon Kim ),( Bo Bin Cha ),( Jin Seop Kim ),( Yeon Gu Choi ),( Gyoo Huh ),( Heun Joo Lee ),( Young Jun Choi ),( Won-serk Kim ),( Ga-young Lee ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2
Fibroblastic mesenchymal tumors show a spectrum of biological behavior, from benign to malignant. We here in report our experience of a distinctive features of superficial CD34-positive fibroblastic tumor (SCPFT), which is a newly described neoplasm, previously undescribed low-grade fibroblastic tumor of the superficial soft tissues. A 45-year-old man presented with subcutaneous nodular lesion on the mid foot area of the right sole. The lesion was near the area of skin graft of the foot, which undergone traumatic amputation by traffic accident 40 years ago. The right foot MR examination revealed 2.0x1.6x0.8 cm sized enhancing mass involving skin and subcutaneous layer. After total excision with supralesional flap surgery, the histopathological study of the 1.9x1.8x0.5 cm sized mass revealed some nodular growing pattern of atypical spindle cell proliferative lesion with distinctive angiomatosis, moderate nuclear atypia, admixed some inflammatory cells in fibro-fatty tissue, and mitotic figures of 1/10 HPFs. The CD34 stain showed diffusely positive reaction for the lesion, and the expression of Ki-67 protein was very low. Finally, the patient was diagnosed with SCPFT. To date, 42 cases of SCPFT have been reported. The incidence rate of this entity is much higher due to the lack of sufficient recognition of this tumor. Herein, we report a rare case of the SCPFT to enhance the recognition and diagnostic level of the disease.
Hematoma beneath nail matrix after finger injury
( Ga-hye Na ),( Bo-ra Lim ),( Do-hyeon Kim ),( Soo-hyeon Noh ),( Eun-jung Kim ),( Kun Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Fingertip injuries are commonly seen, and many of the cases are simple to treat and do not need specialized treatment. However, there are certain conditions where early intervention is warranted for better functional and aesthetic outcomes. A 54-year old man presented with injured fingertip after crushing injury on left 2th finger. Inspection of the digit revealed bluish change of nail plate with erosion on proximal nail fold. Conventional radiograph showed multi-fragmentary fracture of the distal phalanx. After removal of nail plate, nail bed showed bloating. After incision on proximal nail fold, nail matrix showed bloody change with congestion. According to these findings, we diagnosed him as hematoma beneath nail matrix. Then, we incised the transverse line on nail matrix and remove hematoma beneath nail matrix. After this procedure, the patient didn`t complain of any pain. And nail plate showed normal growth without dystrophy. It is difficult to predict solitary nail matrix injury after fingertip injury. Nail matrix injury can cause persistent pain, disturb growth of normal nail plate, and increase the risk of infection. Therefore, evaluating nail matrix in fingertip injury is very important, especially accompanying significant injury to nail fold or digit. And injured nail matrix should be treated by appropriate method.
Kim Hyeon Chang,Lee Hokyou,Lee Hyeok-Hee,Lee Ga Bin,Kim Eunji,Song Moses,Moon Jenny,Seo Yeeun,Korean Society of Hypertension (KSH)-Hypertension Epidemiology Research Working Group 대한고혈압학회 2023 Clinical Hypertension Vol.29 No.-
Background The Korean Society of Hypertension has published the Korea Hypertension Fact Sheet 2022 to provide an overview of the magnitude and management status of hypertension and their recent trends. Methods The Fact Sheets were based on the analyses of Korean adults aged 20 years or older of the 1998–2020 Korea National Health and Nutrition Examination Survey and the 2002–2020 National Health Insurance Big Data. Results As of 2020, 29.4% of the adult population aged 20 or older in Korea, about 12.6 million people, have high blood pressure, of which 5.0 million (40%) are 65 years of age or older and 1.2 million (10%) are 80 years of age or older. Among those with hypertension, the awareness rate is 69%, the treatment rate is 65%, and the control rate is 47%. The number of people diagnosed with hypertension increased from 3.0 million in 2002 to 10.5 million in 2020. During the same period, the number of people using antihypertensive medication increased from 2.5 million to 9.9 million, and the number of people adherent to treatment increased from 0.6 million to 7.4 million. Among those treated for hypertension in 2020, 74% used angiotensin blockers, 61% used calcium channel blockers, 24% used diuretics, and 15% used beta blockers. Combination therapy with at least two classes of antihypertensive medication consisted of 60% of all antihypertensive prescriptions. The number of people with hypertension aged 65 or older is increasing very rapidly compared to those aged 20–64. Awareness and treatment rates of hypertension improved rapidly, especially in those aged 65 or older, but the rate of improvement slowed since 2012. Conclusions In Korea, the level of hypertension management is improving, but the absolute number of people with hypertension, especially elderly hypertension, is increasing due to the rapid aging of the population. It is necessary to develop more efficient and target-specific policies to control blood pressure and prevent cardiovascular disease.