http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
유전독성, 발암성 화학물질이 ROS 생성에 미치는 영향
고서연(Seo Youn Go),신윤용(Yhun Yhong Sheen) 환경독성보건학회 2008 환경독성보건학회지 Vol.23 No.1
In the present study, ROS detection of L5178Y cells that were treated with twenty test compounds in order to find out hydrogen peroxide (H₂O₂) induction for genotoxicity and carcinogenic toxicity. Twenty test compounds were consist of four classes, such as genotoxic carcinogens, genotoxic noncarcinogens, nongenotoxic carcinogens, and nongenotoxic noncarcinogens. Genotoxic carcinogens are 1,2-dibromoethane, glycidol, melphalan, diethylstilbestrol and urethane. Genotoxic noncarcinogens are 8-hydroxyquinoline, emodin, acetonitrile and diallylphthalate, L-ascorbic acid. Nongenotoxic carcinogens are methyl carbamate, O-nitrotoluene, 1,4-dioxane, tetrachloroethylene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. And nongenotoxic noncarcinogens are D-mannitol, 1,2-dichlorobenzene, caprolactam, bisphenol A and chlorpheniramine maleate.
Kim Junsoo,Youn Daehwa,Choi Seunghoon,Lee Youn Woo,Sumberzul Dulguun,Yoon Jeongeun,Lee Hanju,Bae Jong Woo,Noh Hyuna,On Dain,Hong Seung-Min,An Se-Hee,Jang Hui Jeong,Kim Seo Yeon,Kim Young Been,Hwang Ji 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Translational regulation in tissue environments during in vivo viral pathogenesis has rarely been studied due to the lack of translatomes from virus-infected tissues, although a series of translatome studies using in vitro cultured cells with viral infection have been reported. In this study, we exploited tissue-optimized ribosome profiling (Ribo-seq) and severe-COVID-19 model mice to establish the first temporal translation profiles of virus and host genes in the lungs during SARS-CoV-2 pathogenesis. Our datasets revealed not only previously unknown targets of translation regulation in infected tissues but also hitherto unreported molecular signatures that contribute to tissue pathology after SARS-CoV-2 infection. Specifically, we observed gradual increases in pseudoribosomal ribonucleoprotein (RNP) interactions that partially overlapped the trails of ribosomes, being likely involved in impeding translation elongation. Contemporaneously developed ribosome heterogeneity with predominantly dysregulated 5 S rRNP association supported the malfunction of elongating ribosomes. Analyses of canonical Ribo-seq reads (ribosome footprints) highlighted two obstructive characteristics to host gene expression: ribosome stalling on codons within transmembrane domain-coding regions and compromised translation of immunity- and metabolism-related genes with upregulated transcription. Our findings collectively demonstrate that the abrogation of translation integrity may be one of the most critical factors contributing to pathogenesis after SARS-CoV-2 infection of tissues.
Axillary LN meta가 있는 유방암에서 액와 림프절의 FDG uptake가 가지는 임상적 의미
고수희 ( Soo Hee Go ),서형일 ( Hyung Il Seo ),이지연 ( Jee Yeon Lee ),정윤주 ( Youn Joo Jung ) 대한임상종양학회 2010 Korean Journal of Clinical Oncology Vol.6 No.2
Purpose: 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography(18F-FDG PET/CT) has been recommended as a diagnostic modality for preoperative staging of breast cancer. But, the information for FDG uptake on axillary lymph node(ALN) is not sufficient. Authors investigated the FDG uptake on ALN in preoperative 18F-FDG PET/CT and tumor characteristics to figure out their association and its clinical significance. Materials and Methods: From Jan. to Dec. 2007, 176 patients had been performed preoperative 18F-FDG PET/CT. Only sixty-five cases were confirmed as ALN metastasis in pathologic report. Thirty-one patients with high FDG uptake of ALN (SUVmax>1.0) and thirty-four with low FDG uptake (SUVmax≤1.0) in 18F-FDG PET/CT were classified as group A and B, respectively. Results: The FDG uptake of ALN showed significant relationship with poor prognostic factors of primary tumor(worse histologic grade, negativity of estrogen and progesterone receptor, positivity of p53 and c-erbB2 gene, tumor necrosis, lymphovascular invasion) and ALN metastasis. In multivariate analysis, FDG uptake of ALN showed larger tumor size (p=0.001), higher Ki-67 (p=0.004), bigger and more metastatic ALN (p=0.017, <0.001) compared to low FDG uptake of ALN. The cut-off values of high FDG uptake were 1.85 cm of primary tumor size, 17.5% of Ki-67, 2.5 and 0.95 cm of number and size of metastatic ALN. Conclusion: The most valuable sensitivity and specificity of FDG uptake in metastatic ALN were shown when the number and size of ALN was more than 3 or 0.95 cm and they would be large enough to perform ultrasonographyguided biopsy. We recommend preoperative ALN biopsy for the cases of FDG uptake on ALN in preoperative 18FFDG PET/CT and the sentinel lymph node biopsy might be skipped if metastasis is confirmed on biopsy.
Go, Jun,Ha, Thi-Kim-Quy,Seo, Ji Yeon,Park, Tae-Shin,Ryu, Young-Kyoung,Park, Hye-Yeon,Noh, Jung-Ran,Kim, Yong-Hoon,Hwang, Jung Hwan,Choi, Dong-Hee,Hwang, Dae Youn,Kim, Sanghee,Lee, Chul-Ho,Oh, Won Keun Elsevier 2018 Journal of Functional Foods Vol.43 No.-
<P><B>Abstract</B></P> <P>Sirtuin1 (Sirt1) is an unusual target for aging and aging-associated diseases. During the screening for Sirt1 activators from natural compounds, piperlongumine (PL), one of the major constituents of <I>Piper longum</I>, potently activated the deacetylase ability of Sirt1 <I>in vitro</I>. Treatment with PL, which regulated the gene transcription of antioxidant response element in hippocampal neurons, attenuated the cytotoxicity induced by intraneuronal Aβ<SUB>1-42</SUB> expression. The oral administration of PL, at a dose of 50 mg/kg/day for 2.5 months, significantly reduced the occupied area of beta-amyloid in parietal cortex of APP/PS1 mice. Novel object recognition and working memory impairment also markedly improved. Moreover, activated microglia and astrocytes in the cortex notably decreased, indicating the anti-inflammatory activity of PL. Finally, vesicular glutamate transporter 1 significantly increased in the hippocampus of APP/PS1 mice following PL treatment. These results suggested the beneficial effects PL and its therapeutic potential to ameliorate AD-like pathology.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Piperlongumine (PL) activates the deacetylase ability of Sirt1 <I>in vitro</I>. </LI> <LI> PL improves cognitive deficits in APP/PS1 mice. </LI> <LI> PL reduces amyloid deposition and neuro-inflammation in the brain of APP/PS1 mice. </LI> <LI> PL increases VGLUT1 level in the hippocampus of APP/PS1 mice. </LI> </UL> </P>
치주 조직 재생을 위한 3D 프린터로 제작된 흡수성 차폐막의 물리적 및 생분해성 특성
고혜빈(Hye-Bin Go),서경진(Kyoung-Jin Seo),천연욱(Youn Wook Chun),이승원(Seung Won Lee),유성민(Sung Min You),임범순(Bum-Soon Lim),권재성(Jae-Sung Kwon) 대한치과재료학회 2021 대한치과재료학회지 Vol.48 No.2
The purpose of this study was to compare physical and biodegradable properties of 3D printed resorbable membranes that are used for guided tissue regenerations in periodontal tissues. Three types of 3D printed membranes (two types of non β-TCP and one type of β-TCP) were considered. The form and element compositions of 3D printed membranes were analyzed by field-emission scanning electron microscopy (FE-SEM) with energy-dispersive X-ray spectroscopy (EDS). Porosity and pore size were measured using Micro-CT. Also, tensile strength, biodegradability tests were performed. Statistical analyses were carried in tensile strength and cell viability test (p<0.05). The result of SEM images with EDS analyses showed linear layers of lattice structure with presence of C and O in all groups. There was a slight difference in Ca and P among some groups. Tensile strength was significantly different among all groups (p<0.05), and biodegradability showed that the group containing β-TCP resulted in the fastest degradation rate. Therefore, the results of this study concluded that the 3D printed resorbable membrane has variable physical and biodegradable properties for clinical use, where such information would be useful to be considered for the future development of related products and clinical application of the products.
Genetic Toxicity Test of o-Nitrotoluene by Ames, Micronucleus, Comet Assays and Microarray Analysis
Lee, Eun-Mi,Lee, So-Youn,Lee, Woo-Sun,Kang, Jin-Seok,Han, Eui-Sik,Go, Seo-Youn,Sheen, Yhun-Yong,Kim, Seung-Hee,Park, Sue-Nie The Korean Society of Toxicogenomics and Toxicopro 2007 Molecular & cellular toxicology Vol.3 No.2
o-Nitrotoluene is used to synthesize artificial dyes and raw materials of urethane resin. In this study, we have carried out in vitro genetic toxicity tests and microarray analysis to understand the underlying mechanisms and the mode of action of toxicity of onitrotoluene. TA1535 and TA98 cells were treated with o-nitrotoluene to test its toxicity by basic genetic toxicity test. Ames and two new in vitro micronucleus and COMET assays were applied using CHO cells and L5178Y cells, respectively. In addition, microarray analysis of differentially expressed genes in L5178Y cells in response to o-nitrotoluene was analyzed using Affymatrix genechip. The result of Ames test was that o-nitrotoluene treatment did not increase the mutations both in base substitution strain TA1535 and in frame shift TA98. o-Nitrotoluene has not increased micronuclei in CHO cells. But onitrotoluene increased DNA damage in L5178Y cell. Two-hundred two genes were initially selected as differentially expressed genes in response to o-nitrotoluene by microarray analysis and forty four genes among them were over 2 times of log fold changed. These forty four genes could be candidate biomarkers of genetic toxic action of o-nitrotoluene related to induction of mutation and/or induction of micronuclei and DNA damage. Further confirmation of these candidate markers related to the DNA damage will be useful to understand the detailed mechanism of action of o-nitrotoluene.