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Graphene oxide assisted spontaneous growth of V2O5 nanowires at room temperature.
Lee, Minoh,Hong, Won G,Jeong, Hu Young,Balasingam, Suresh Kannan,Lee, Zonghoon,Chang, Sung-Jin,Kim, Byung Hoon,Jun, Yongseok RSC Pub 2014 Nanoscale Vol.6 No.19
<P>Graphene-decorated single crystalline V2O5 nanowires (G-VONs) have been synthesized by mixing graphene oxide (GO) and V2O5 suspensions at room temperature. In this process, V2O5 nanowires (VONs) are formed spontaneously from commercial V2O5 particles with the aid of GO. The as-formed one dimensional G-VONs were characterized by using a X-ray diffractometer, a X-ray photoelectron spectrometer, a scanning electron microscope, and a transmission electron microscope. GO plays a vital role in the VON formation with the simultaneous reduction of GO. A single G-VON showed superior electrical conductivity compared with that of the pure VONs obtained from the sol-gel method. This could be ascribed to the insertion of rGO sheets into the V2O5 layered structure, which was further confirmed by electron energy loss spectroscopy.</P>
Sun, Z.H.,Tan, Z.L.,Yao, J.H.,Tang, Z.R.,Shan, J.G.,Hu, J.P.,Tang, S.X.,Jiang, Y.M. Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.5
The effects of intra-duodenal infusion of methionine (Met), lysine (Lys) and leucine (Leu) on dry matter intake (DMI), the concentrations of insulin-like growth factor I (IGF-I), growth hormone (GH) and insulin in plasma, and liver IGF-I mRNA level were investigated in two experiments for Liuyang Black growing wether goats. In Experiment 1, three goats ($10.0{\pm}0.1$ kg) were fitted with ruminal, proximal duodenal and terminal ileal fistulaes to determine the infusion amounts of Met, Lys and Leu at the duodenum according to essential amino acid flows into the duodenum and their apparent digestibility. The infusion amounts were 0.77 g/d, 0.91 g/d and 0.58 g/d respectively. In Experiment 2, 4 groups of goats (($10.0{\pm}0.2$ kg) for each group, were cannulated at the duodenum, and were infused with a mixture of Met, Lys and Leu (Control), or mixtures with 21% Met, Lys or Leu replaced with glutamate respectively on a nitrogenous basis. The replacement of 21% Met, Lys or Leu with glutamate did not affect intakes of maize stover, concentrate or both (p>0.05) when compared with the control. The replacement of 21% Met or Lys significantly (p<0.05) reduced plasma GH, insulin and IGF-I concentrations and liver IGF-I mRNA level. The replacement of 21% Leu with glutamate reduced (p<0.05) plasma IGF-I concentration only, but not plasma insulin and GH, as well as liver IGF-I mRNA level (p>0.05). The close relationships between supplying Met and Lys in the lumen of the duodenum and plasma IGF-I, GH and insulin concentrations, as well as liver IGF-I mRNA level in this study indicate that the effects of the limiting amino acids on nutrition of animals are likely intermediated via their effects on these hormones, and these hormone profiles could be used as intermediate markers for the limiting order of amino acids.
Ma X. G.,Yang X. D.,Hu H. X.,Zheng Y. G. 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.80 No.10
Sand concentration and particle size are the main factors that afect the erosion of solid surfaces under the impact of solid particles in liquid–solid two-phase fow. In this study, fve sand concentrations (1 wt%, 3 wt%, 5 wt%, 10 wt%, and 20 wt%) and fve particle sizes (20 μm, 75 μm, 125 μm, 300 μm, and 425 μm) were used for V-groove Surface mud erosion is simulated. Gambit and Ansys Fluent were used to simulate the anti-erosion performance of the V-shaped groove. The fow feld near the V-shape grooved surface was analyzed for the explanation of the erosion behavior. Corresponding experiments were also carried out to verify the simulation. The results showed that the slurry erosion of the V-shape grooved surface increased with the increasing sand concentration. There was a critical particle size between 25 μm and 75 μm, above which the slurry erosion remained stable with the particle size. In addition, no great change occurred in the fow style for all cases with diferent sand concentrations and particle sizes. The erosion area did not change with the increasing sand concentration but enlarged with the increasing particle size. The erosion mechanism with diferent sand concentrations and particle sizes was also discussed.
X.-K ZHANG,G. J. ZHENG,J.-N. HU,C. G. LI,P. HU 한국자동차공학회 2010 International journal of automotive technology Vol.11 No.5
−To more accurately manufacture an auto-body workpiece, a predictive compensation factor method was used to predict the workpiece’s springback, and the factors influencing springback are introduced. Based on this method, a numerical simulation was produced to simulate the springback compensation after distortion of the workpiece. After analyzing the simulation results, a compensation method was introduced to reduce the springback influence on an actual workpiece. Here, we used a fortified B-pillar, which is a kind of longitudinal stand-frame workpiece, made with a high-strength steel material (TRIP700). The simulation results indicated that the proposed method is feasible and can be efficiently used for predicting the distortion of springback compensation of an auto-body workpiece.
<i>BRCA2</i> Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
Shimelis, Hermela,Mesman, Romy L.S.,Von Nicolai, Catharina,Ehlen, Asa,Guidugli, Lucia,Martin, Charlotte,Callé,ja, Fabienne M.G.R.,Meeks, Huong,Hallberg, Emily,Hinton, Jamie,Lilyquist, Jenna,Hu, American Association for Cancer Research 2017 Cancer Research Vol.77 No.11
<P>These results show how BRCA2 missense variants that partially influence protein function can confer clinically relevant increased risks of breast cancer, with potential implications for risk management of women who harbor specific variants.</P><P>Breast cancer risks conferred by many germline missense variants in the <I>BRCA1</I> and <I>BRCA2</I> genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations between 19 BRCA1 and 33 BRCA2 missense substitution variants and breast cancer risk were investigated through a breast cancer case–control study using genotyping data from 38 studies of predominantly European ancestry (41,890 cases and 41,607 controls) and nine studies of Asian ancestry (6,269 cases and 6,624 controls). The BRCA2 c.9104A>C, p.Tyr3035Ser (OR = 2.52; <I>P</I> = 0.04), and BRCA1 c.5096G>A, p.Arg1699Gln (OR = 4.29; <I>P</I> = 0.009) variant were associated with moderately increased risks of breast cancer among Europeans, whereas BRCA2 c.7522G>A, p.Gly2508Ser (OR = 2.68; <I>P</I> = 0.004), and c.8187G>T, p.Lys2729Asn (OR = 1.4; <I>P</I> = 0.004) were associated with moderate and low risks of breast cancer among Asians. Functional characterization of the BRCA2 variants using four quantitative assays showed reduced BRCA2 activity for p.Tyr3035Ser compared with wild-type. Overall, our results show how BRCA2 missense variants that influence protein function can confer clinically relevant, moderately increased risks of breast cancer, with potential implications for risk management guidelines in women with these specific variants. <I>Cancer Res; 77(11); 2789–99. ©2017 AACR</I>.</P>
Hu, Bingjie,Zhu, Xiaolei,Monroe, Lyman,Bures, Mark G.,Kihara, Daisuke MDPI 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.9
<P>Structure-based computational methods have been widely used in exploring protein-ligand interactions, including predicting the binding ligands of a given protein based on their structural complementarity. Compared to other protein and ligand representations, the advantages of a surface representation include reduced sensitivity to subtle changes in the pocket and ligand conformation and fast search speed. Here we developed a novel method named PL-PatchSurfer (Protein-Ligand PatchSurfer). PL-PatchSurfer represents the protein binding pocket and the ligand molecular surface as a combination of segmented surface patches. Each patch is characterized by its geometrical shape and the electrostatic potential, which are represented using the 3D Zernike descriptor (3DZD). We first tested PL-PatchSurfer on binding ligand prediction and found it outperformed the pocket-similarity based ligand prediction program. We then optimized the search algorithm of PL-PatchSurfer using the PDBbind dataset. Finally, we explored the utility of applying PL-PatchSurfer to a larger and more diverse dataset and showed that PL-PatchSurfer was able to provide a high early enrichment for most of the targets. To the best of our knowledge, PL-PatchSurfer is the first surface patch-based method that treats ligand complementarity at protein binding sites. We believe that using a surface patch approach to better understand protein-ligand interactions has the potential to significantly enhance the design of new ligands for a wide array of drug-targets.</P>
Hu, Jinchuan,Choi, Jun-Hyuk,Gaddameedhi, Shobhan,Kemp, Michael G.,Reardon, Joyce T.,Sancar, Aziz American Society for Biochemistry and Molecular Bi 2013 The Journal of biological chemistry Vol.288 No.29
<P>Nucleotide excision repair is the sole mechanism for removing the major UV photoproducts from genomic DNA in human cells. <I>In vitro</I> with human cell-free extract or purified excision repair factors, the damage is removed from naked DNA or nucleosomes in the form of 24- to 32-nucleotide-long oligomers (nominal 30-mer) by dual incisions. Whether the DNA damage is removed from chromatin <I>in vivo</I> in a similar manner and what the fate of the excised oligomer was has not been known previously. Here, we demonstrate that dual incisions occur <I>in vivo</I> identical to the <I>in vitro</I> reaction. Further, we show that transcription-coupled repair, which operates in the absence of the XPC protein, also generates the nominal 30-mer in UV-irradiated XP-C mutant cells. Finally, we report that the excised 30-mer is released from the chromatin in complex with the repair factors TFIIH and XPG. Taken together, our results show the congruence of <I>in vivo</I> and <I>in vitro</I> data on nucleotide excision repair in humans.</P>