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RISS 인기검색어
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- 저자 : Firooz Samadi (검색결과 2 건)
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Effects of Atorvastatin in Patients with Acute Spinal Cord Injury
Javad Aghazadeh,Parviz Samadi Motlagh,Firooz Salehpour,Ali Meshkini,Majid Fatehi,Farhad Mirzaei,Seyed Ahmad Naseri Alavi 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.6
Study Design: Clinical trial study. Purpose: The aim of this study was to evaluate the effect of atorvastatin on sensory and motor function in patients with acute spinal cord injury. Overview of Literature: The prevalence and incidence of traumatic spinal cord injury are increasing. Statins are well established for use in hypercholesterolemia as well as during anti-inflammatory events. Methods: This clinical trial study included 60 patients with acute spinal cord injury. These were randomly divided into two groups: the case group which received atorvastatin and also underwent surgical therapy and the control group which only underwent surgical therapy. Results: The severity of spinal cord lesions was evaluated based on the Frankel grade at three periods; this showed no significant difference between the two groups. Comparisons of the levels of pain between the groups based on a Visual Analog Scale system showed no significant difference at the three periods. Conclusions: We observed no improvement at the 3- and 6-month follow-up in patients who were administered atorvastatin. However, a comparison of the two groups based on pain severity demonstrated a significant difference, suggesting that atorvastatin had a positive effect on patients with spinal cord injury.
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Effects of intraperitoneal administration of Papaver rhoeas L. extract on mouse ovaries
Afsaneh Golkar-Narenji,Hussein Eimani,Firooz Samadi,Saeid Hasani,Abdol hossein Shahverdi,Poopak Eftekhari-Yazi,Mohammad Kamalinejad 한국통합생물학회 2013 Animal cells and systems Vol.17 No.2
This research studies the effect of water-alcohol Papaver rhoeas L. (P. rhoeas) extract on mouse ovaries and in vitro development (IVD) of oocytes. Different dosages of P. rhoeas extract (25, 50, 100, 200 mg/kg body weight) were injected intraperitoneally (i.p.) during a period of 12 days. Following superovulation, the numbers of ovulated oocytes, the rates of in vitro fertilization, IVD and the cellularity of blastocysts were recorded. Additionally, effect of the best dosage on ovarian follicle population and the ability of immature oocytes to mature in vitro were evaluated. Administration of 200 mg/kg significantly increased the percentage of 48 cells, morula and blastocyst embryos compared to the control group (pB0.05). Furthermore, total cellularity of blastocysts was significantly higher with the administration of 200 mg/kg of extract in comparison to control group (pB0.05). Therefore, the most effective dosage was considered to be 200 mg/kg. With the administration of 200 mg/kg no marked changes were observed in the IVM rate of retrieved oocytes from treated group in comparison to control group. Furthermore, the percentage of ovarian follicles was not significantly different when compared to control group. Also, during visual evaluations no abnormal apoptosis was detected in follicles of ovaries treated with 200 mg/kg when compared to control group. Higher IVD and blastocyst cellularity in the group treated with defined dosage of P. rhoeas indicates that the extract affects ovaries in a dose dependent manner. The extract possibly increases the quality of ovulated oocytes and IVD competence of oocytes.
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