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Ferretti, James A. Korean Society for Biochemistry and Molecular Biol 2001 Journal of biochemistry and molecular biology Vol.34 No.1
Structural and physical properties of type wild type and various selected mutants of the vnd/NK-2 homeodomain, the protein product of the homeobox, and the implication in genetic disease are reviewed. The structure, dynamics and thermodynamics have been Investigated by NMR and by calorimetry. The interactions responsible for the nucleotide sequence-specific binding of the homeodomain to its consensus DNA binding site have been identified. There is a strong correlation between significant structural alterations within the homeodomain or its DNA complex and the appearance of genetic disease. Mutations in positions known to be important in genetic disease have been examined carefully For example, mutation of position 52 of vnd/NK-2 results in a significant structural modification and mutation of position 54 alters the DNA binding specificity and amity The $^{15}N$ relaxation behavior and heteronuclear Overhauser effect data was used to characterize and describe the protein backbone dynamics. These studies were carried out on the wild type and the double mutant proteins both in the free and in the DNA bound states. Finally, the thermodynamic properties associated with DNA binding are described for the vnd/NK-2 homeodomain. These thermodynamic measurements reinforce the hypothesis that water structure around a protein and around DNA significantly contribute to the protein-DNA binding behavior. The results, taken together, demonstrate that structure and dynamic studies of proteins combined with thermodynamic measurements provide a significantly more complete picture of the solution behavior than the individual studies.
(James A . Ferretti) 생화학분자생물학회 2001 BMB Reports Vol.34 No.1
Structural and physical properties of type wild type and various selected mutants of the vnd/NK-2 homeodomain, the protein product of the homeobox, and the implication in genetic disease are reviewed. The structure, dynannies and thermodynamics have been Investigated by NMR and by calorimetry. The interactions responsible for the nucleotide sequence-specific bimling of the homeodomain to its consensus DNA binding site have been identified. There is a strong correlation between significant structural alteratfons within the homeodomain or its DNA complex and the appearance of genetic disease. Mutations in positions known to be important in genetic disease have been examined carefully For example, mutation of position 52 of vnd/NK-2 results in a significant structural modification and mutation of position 54 alters the DNA binding specificity and amity The ^(15)N relaxation behavior and heteronuclear Overhauser effect data was used to characterize and describe the protein backbone dynamics. These studies were carried out on the wild type and the double mutant proteins both in the free and in the DNA bound states. Finally, the thermodynamic properties associated with DNA binding are described for the vnd/NK-2 homeodomain. These thermodynamic measurements reinforce the hypothesis that water structure around a protein and around DNA significantly contribute to the protein-DNA binding behavior. The results, taken together, demonstrate that structure and dynamic studies of proteins combined with thermodynamic measurements provide a significantly more complete picture of the solution behavior than the individual studies.
Revealing timid pseudo-scalars with taus at the LHC
Cacciapaglia, Giacomo,Ferretti, Gabriele,Flacke, Thomas,Serô,dio, Hugo Springer Berlin Heidelberg 2018 The European physical journal. C, Particles and fi Vol.78 No.9
<P>A light pseudo-scalar that is copiously produced at the LHC may still be allowed by present searches. While masses above 65 GeV are effectively covered by di-photon searches, the lower mass window can be tested by a new search for boosted di-tau resonances. We test this strategy on a set of composite Higgs models with top partial compositeness, where most models can be probed with an integrated luminosity below 300 [FORMULA OMISSION].</P>
Soyeon Park,Charlotte Ferretti,Gretchen Ames 육아정책연구소 2012 International Journal of Child Care and Education Vol.6 No.2
This 10 year overview of a citywide program implemented to improve the quality of childcare and education in San Francisco provides a description of critical issues related to implementation of an assessment process as well as factors thatinfluence success related to initiating and sustaining quality improvement efforts in early care and education (ECE). The population of interest included all licensed childcare programs and family childcare homes in the city and county of San Francisco receiving public funding and those serving families with subsidies. The assessmenttool chosen by city childcare leaders was the Environmental Rating Scales (ERS) for preschool, infant toddler and family childcare sites. Quality improvement plans were developed based on the results of the assessment of each classroom or family childcare home, followed by technical assistance targeted at improving the quality of the environment and teaching practice. Because assessment scores are currently tied to city funded subsidies, motivation for participation in the program becomes a critical factor for those programs that depend on the subsidies. Lessons learned can support other endeavors to improve the quality of childcare and education and include engaging ECE teachers in intentional dialogue that results in internal motivation to improve the quality of their teaching, along with systemic supports that include teachers, families and funding streams to sustain quality care.
Trends and seasonal cycles in the isotopic composition of nitrous oxide since 1940
Park, S.,Croteau, P.,Boering, K. A.,Etheridge, D. M.,Ferretti, D.,Fraser, P. J.,Kim, K-R.,Krummel, P. B.,Langenfelds, R. L.,van Ommen, T. D.,Steele, L. P.,Trudinger, C. M. Springer Science and Business Media LLC 2012 Nature geoscience Vol.5 No.4