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RISS 인기검색어
- 검색키워드
- 저자 : Fatemeh Jaleh (검색결과 3 건)
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Fatemeh Seifikar,Saeid Azizian,Atefeh Nasri,Babak Jaleh 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
Nanofluids are colloidal systems broadly used in solar-energy utilization. The main disadvantages ofnanofluids are their instability and time-consuming preparation methods, the aim of the present workis to introduce a nanofluid without the mentioned problems. Herein, two colloidal systems of vanadium including V/PEG (for the first time) and V/H2O nanofluidswere synthesized by laser ablation in liquid method in polyethylene glycol and water, respectively andutilized in light-to-heat conversion. V/PEG is more stable than V/H2O as the oxidation state of vanadiumis unchanged in polyethylene glycol but in water is changed until V2O5 is obtained. Unlike V/H2O, noagglomeration/precipitation takes place for V/PEG. Based on the images obtained from transmission electronmicroscopy, vanadium nanoparticles have different morphologies and sizes, helping V/PEG to absorbdifferent wavelengths, resulting in more heat generation. The surface temperature of V/PEG reached ffi 57℃ (DT ffi 30 ℃), under 60 min sunlight irradiation (0.9 Sun). The V/PEG was used at high light intensitiesand several successive heating–cooling cycles without losing its heat-generation performance. Differentcalculated thermo-physical parameters reveal that V/PEG is more eligible than V/H2O in photo-thermalconversion with several advantages: inexpensive and simple synthesis, dispersant-free, long-colloidalstability, high photo-thermal durability and high heat-generation efficiency.
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Sedigheh Molaei,Mehryar Habibi Roudkenar,Fatemeh Amiri,Mozhgan Dehghan Harati,Marzie Bahadori,Fatemeh Jaleh,Mohammad Ali Jalili,Amaneh Mohammadi Roushandeh 대한혈액학회 2015 Blood Research Vol.50 No.2
Background Mesenchymal stem cells (MSCs) are valuable for cell-based therapy. However, their applicationis limited owing to their low survival rate when exposed to stressful conditions. Autophagy, the process by which cells recycle the cytoplasm and dispose of defectiveorganelles, is activated by stress stimuli to adapt, tolerate adverse conditions, or triggerthe apoptotic machinery. This study aimed to determine whether regulation of autophagywould affect the survival of MSCs under stress conditions. Methods Autophagy was induced in bone marrow-derived MSCs (BM-MSCs) by rapamycin, andwas inhibited via shRNA-mediated knockdown of the autophagy specific gene, ATG7. ATG7 expression in BM-MSCs was evaluated by reverse transcription polymerase chainreaction (RT-PCR), western blot, and quantitative PCR (qPCR). Cells were then exposedto harsh microenvironments, and a water-soluble tetrazolium salt (WST)-1 assay was performedto determine the cytotoxic effects of the stressful conditions on cells. Results Of 4 specific ATG7-inhibitor clones analyzed, only shRNA clone 3 decreased ATG7expression. Under normal conditions, the induction of autophagy slightly increased theviability of MSCs while autophagy inhibition decreased their viability. However, understressful conditions such as hypoxia, serum deprivation, and oxidative stress, the inductionof autophagy resulted in cell death, while its inhibition potentiated MSCs to withstandthe stress conditions. The viability of autophagy-suppressed MSCs was significantlyhigher than that of relevant controls (P<0.05, P<0.01 and P<0.001). Conclusion Autophagy modulation in MSCs can be proposed as a new strategy to improve their survivalrate in stressful microenvironments.
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Sedigheh Molaei,Mehryar Habibi Roudkenar,Fatemeh Amiri,Mozhgan Dehghan Harati,Marzie Bahadori,Fatemeh Jaleh,Mohammad Ali Jalili,Amaneh Mohammadi Roushandeh 대한혈액학회 2015 Blood Research Vol.50 No.2
Background Mesenchymal stem cells (MSCs) are valuable for cell-based therapy. However, their applicationis limited owing to their low survival rate when exposed to stressful conditions. Autophagy, the process by which cells recycle the cytoplasm and dispose of defectiveorganelles, is activated by stress stimuli to adapt, tolerate adverse conditions, or triggerthe apoptotic machinery. This study aimed to determine whether regulation of autophagywould affect the survival of MSCs under stress conditions. Methods Autophagy was induced in bone marrow-derived MSCs (BM-MSCs) by rapamycin, andwas inhibited via shRNA-mediated knockdown of the autophagy specific gene, ATG7. ATG7 expression in BM-MSCs was evaluated by reverse transcription polymerase chainreaction (RT-PCR), western blot, and quantitative PCR (qPCR). Cells were then exposedto harsh microenvironments, and a water-soluble tetrazolium salt (WST)-1 assay was performedto determine the cytotoxic effects of the stressful conditions on cells. Results Of 4 specific ATG7-inhibitor clones analyzed, only shRNA clone 3 decreased ATG7expression. Under normal conditions, the induction of autophagy slightly increased theviability of MSCs while autophagy inhibition decreased their viability. However, understressful conditions such as hypoxia, serum deprivation, and oxidative stress, the inductionof autophagy resulted in cell death, while its inhibition potentiated MSCs to withstandthe stress conditions. The viability of autophagy-suppressed MSCs was significantlyhigher than that of relevant controls (P<0.05, P<0.01 and P<0.001). Conclusion Autophagy modulation in MSCs can be proposed as a new strategy to improve their survivalrate in stressful microenvironments.
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