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Shoraka, Hamid Reza,Haghdoost, Ali Akbar,Baneshi, Mohammad Reza,Bagherinezhad, Zohre,Zolala, Farzaneh The Korean Pediatric Society 2020 Clinical and Experimental Pediatrics (CEP) Vol.63 No.2
Phenylketonuria is a disease caused by congenital defects in phenylalanine metabolism that leads to irreversible nerve cell damage. However, its detection in the early days of life can reduce its severity. Thus, many countries have started disease screening programs for neonates. The present study aimed to determine the worldwide prevalence of classic phenylketonuria using the data of neonatal screening studies.The PubMed, Web of Sciences, Sciences Direct, ProQuest, and Scopus databases were searched for related articles. Article quality was evaluated using the Joanna Briggs Institute Critical Appraisal Evaluation Checklist. A random effect was used to calculate the pooled prevalence, and a phenylketonuria prevalence per 100,000 neonates was reported. A total of 53 studies with 119,152,905 participants conducted in 1964-2017 were included in this systematic review. The highest prevalence (38.13) was reported in Turkey, while the lowest (0.3) in Thailand. A total of 46 studies were entered into the meta-analysis for pooled prevalence estimation. The overall worldwide prevalence of the disease is 6.002 per 100,000 neonates (95% confidence interval, 5.07-6.93). The meta-regression test showed high heterogeneity in the worldwide disease prevalence (I<sup>2</sup>=99%). Heterogeneity in the worldwide prevalence of phenylketonuria is high, possibly due to differences in factors affecting the disease, such as consanguineous marriages and genetic reserves in different countries, study performance, diagnostic tests, cutoff points, and sample size.
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The increasing trend of blood donation in Iran
Moslem Taheri Soodejani,Ali Akbar Haghdoost,Abbas Sedaghat,Mohammad Reza Baneshi,Farzaneh Zolala 대한혈액학회 2019 Blood Research Vol.54 No.4
BackgroundThis is the first study on the blood donation trend in Iran at a national level. We report different characteristics of blood donation such as demographic status, donor type, dona-tion trend, and geographical distribution of blood donation in Iran between 2003 and 2017.MethodsThis study used data registered in the donor vigilance part of the Iranian Blood Transfusion Organization. Statistical analysis was conducted using SPSS (SPSS Inc., Chicago, IL, USA) and ArcMap GIS version 10.2 software. A P-value <0.05 was considered statistically significant.ResultsBased on the study results, blood donation in Iran reached >2 million units in 2017; more-over, it is predicted that Iran will achieve >29 donations per 1,000 population in 2022. The proportion of regular and repeated donors increased from 77% in 2013 to 87% in 2017. The average blood donation rate in seven provinces was higher than the national average, and the average growth rate of their blood donation per population was positive.ConclusionThe results of the current study showed that there is a recent increasing trend toward blood donation in Iran. Furthermore, the largest share of donations is related to regular donors. The increasing proportion of regular and repeated donors has led to the improve-ment in the quality and consequently health level of donated blood.
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