Comparison of advanced stage mucinous epithelial ovarian cancer and serous epithelial ovarian cancer with regard to chemosensitivity and survival outcome: a matched case-control study

Emine Karabuk,M. Faruk Kose,Deniz Hizli,Salih Taşkin,Burak Karadağ,Taner Turan,Nurettin Boran,Ahmet Ozfuttu,U. Fırat Ortaç 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.2

Objective: The aim of this study was to compare clinicopathologic characteristics, surgery outcomes and survival outcomes of patients with stage III and IV mucinous epithelial ovarian cancer (mEOC) and serous epithelial ovarian carcinoma (sEOC). Methods: Patients who had surgery for advanced stage (III or IV) mEOC were evaluated retrospectively and defined as the study group. Women with sEOC who were matched for age and stage of disease were randomly chosen from the database and defined as the control group. The baseline disease characteristics of patients and platinum-based chemotherapy efficacy (response rate, progression-free survival and overall survival [OS]) were compared. Results: A total of 138 women were included in the study: 50 women in the mEOC group and 88 in the sEOC group. Patients in the mEOC group had significantly less grade 3 tumors and CA-125 levels and higher rate of para-aortic and pelvic lymph node metastasis. Patients in the mEOC group had significantly less platinum sensitive disease (57.9% vs. 70.8%; p=0.03) and had significantly poorer OS outcome when compared to the sEOC group (p=0.001). The risk of death for mEOC patients was significantly higher than for sEOC patients (hazard ratio, 2.14; 95% confidence interval, 1.34 to 3.42). Conclusion: Advanced stage mEOC patients have more platinum resistance disease and poorer survival outcome when compared to advanced stage sEOC. Therefore, novel chemotherapy strategies are warranted to improve survival outcome in patients with mEOC.

The fuzzy logic-based modeling of a micro-scale sloped solar chimney power plant

Muhammed Huseyin Guzel,Recep Emre Unal,Ahmet Onder,Muhammed Arif Sen,Faruk Kose 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.3

The energy demand of world is increasing worldwide because of increasing population and developing technology. The use of environmentally friendly renewable resources is very important in providing the increasing energy needs. In the renewable energy sources, the solar energy has a strategic importance because of its huge potential and unlimited. The production of electrical energy by solar chimney power plants is one of the reliable and profitable methods. Fuzzy logic-based approaches are commonly used for modeling different systems in many fields. Also, a renewable energy system can be modelled by fuzzy definitions. In this way, it can provide efficiently and quickly theoretical estimates of systems with productive simulations. In this study, using the experimental data obtained from the micro-scale sloped solar chimney power plant in carried on scientific research project by authors, the obtaining and verifying a fuzzy logic-based model (FLBM) that can calculate the change in air velocity at turbine according to the change of radiation and temperature is presented. The air velocity at the turbine inlet is the considerable variable determining the electricity generation in a solar chimney. Thus, the output of the model is determined as this air velocity. In changes in the radiation and temperature values are defined as inputs. A two input-one output fuzzy model is obtained, in which the inference method is designed in the form of Mamdani and the membership functions in the form of the triangle, making inferences according to the rule base determined by the experience achieved from the experimentally studies. In order to investigate the accuracy of the FLBM, the simulation results and the data get from experimental setup in April 2019 are compared and evaluated. The validation of the FLBM compared to the experimental system is investigated using different error evaluation criteria. It is proved that the results of FLBM and experimental data are realized at a high rate (95.95 %) close to each other and similarly.

Accuracy of Frozen Sections for Intraoperative Diagnosis of Complex Atypical Endometrial Hyperplasia

Turan, Taner,Karadag, Burak,Karabuk, Emine,Tulunay, Gokhan,Ozgul, Nejat,Gultekin, Murat,Boran, Nurettin,Isikdogan, Zuhal,Kose, Mehmet Faruk Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Objective: The purpose of this study was to correlate the histological diagnosis made during intraoperative frozen section (FS) examination of hysterectomy samples with complex atypical endometrial hyperplasia (CAEH) diagnosed with definitive paraffin block histology. Methods: FS pathology results of 125 patients with a preoperative biopsy showing CAEH were compared retrospectively with paraffin block pathology findings. Results: Paraffin block results were consistent with FS in 78 of 125 patients (62.4%). The FS sensitivity and specificity of detecting cancer were 81.1% and 97.9%, with negative and positive predictive values of 76.7%, and 98.4%, respectively. Paraffin block results were reported as endometrial cancer in 77 of 125 (61.6%) patients. Final pathology was endometrial cancer in 45.3% patients diagnosed at our center and 76.9% for patients who had their diagnosis at other clinics (p=0.018). Paraffin block results were consistent with FS in 62.4% of all cases Consistence was 98.4% in patients who had endometrial cancer in FS. Conclusion: FS does not exclude the possibility of endometrial cancer in patients with the preoperative diagnosis of CAEH. In addition, sufficient endometrial sampling is important for an accurate diagnosis.

Early and Late Complications after Inguinofemoral Lymphadenectomy for Vulvar Cancer

Cirik, Derya Akdag,Karalok, Alper,Ureyen, Isin,Tasci, Tolga,Kalyoncu, Rukiye,Turkmen, Osman,Kose, M Faruk,Tulunay, Gokhan,Turan, Taner Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13

Background: We aimed to determine the frequency of early and late complications following groin surgery for vulvar cancer and analyze possible risk factors. Materials and Methods: This retrospective cohort study included 99 women who underwent for vulvar cancer. The early (${\leq}1$ month) complications were wound infection, breakdown and lymphocyst and late (>1 month) complications were lower limb lymphedema, incontinence and erysipelas. The risk factors for developing each of the complications were analyzed with regression analysis. Results: In the entire cohort, 29 (29.3%) women experienced early and 12 (12.1%) had late complications. Wound complications including infection and breakdown were the leading early complications (23.2%). In the multivariate analysis, both obesity (body mass index ${\geq}30kg/m^2$) and advanced age (${\geq}65years$) were found as independent predictive factors for early complications. Obese women of advanced age had 6.32 times more risk of experiencing any of the early complications, when compared to non-obese and young women (55.6% vs 8.7%). The most common late complication was lower limb lymphedema (10.1%) that was more frequently seen in young women. However, neither age nor lymph node count were significantly associated with the occurrence of lower limb lymphedema. Conclusions: More than 40% of the women suffered from postoperative complications after inguinofemoral lymphadenectomy in the current study. While advanced age and obesity were the significant predictors for any of the early complications, there was no identified risk factor for lower limb lymphedema.

Ovarian Transposition for Stage Ib Squamous Cell Cervical Cancer - Lack of Effects on Survival Rates?

Turan, A. Taner,Keskin, H. Levent,Dundar, Betul,Gundogdu, Burcu,Ozgul, Nejat,Boran, Nurettin,Tulunay, Gokhan,Kose, M. Faruk Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Background: To investigate the impact of ovarian transposition (OT) on survival rates of the patients with stage Ib squamous cell cervical cancer. Materials and Methods: Ninety-two subjects who underwent a radical hysterectomy including oophorectomy were evaluated. For nineteen (20.7%), OT was performed. Patients were divided into two groups, OT versus oophorectomy alone. The primary end-point of this study was to investigate the impact of OT on tumor recurrence rate and time, 5-year disease-free survival (DFS) and overall survival (OS). These comparisons were performed for subgroups including patients who received radiotherapy versus who did not. Statistical analyses were conducted using the Chi-square test, T-test and Mann-Whitney test. OS was examined using the Kaplan-Meier method. $P{\leq}0.05$ was considered to be statistically significant. Results: The median follow-up period was 89 months for OT and 81 months for the oophorectomy group (p>0.05). Both groups experienced similar recurrence rates (31.6% vs. 26.4%, p=0.181). The median duration from surgery to recurrence, and surgery to death were also similar between the groups (p>0.05). The 5-year DFS and OS rates were both 68.4% for the OT group, and 73.6% and 77.8% for the oophorectomy group (p=0.457 and p=0.307, respectively). While the 5-year DFS rate was not statistically significant between the OT and oophorectomy groups who did not receive radiotherapy (p=0.148), the 5-year OS rate was significantly higher in the oophorectomy group (95.4% vs 66.7%, respectively) without radiotherapy (p=0.05). The 5-year DFS and OS rates were statistically similar between the groups who received adjuvant radiotherapy (p>0.05). Conclusions: Ovarian transposition has not significantly negative effect on the survival rates when adjuvant radiotherapy will be applied, while 5-year OS may be less in OT group if radiotherapy is not mandatory.