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Spinal Growth Modulation with Use of a Tether in an Immature Porcine Model :
Newton, Peter O,Upasani, Vidyadhar V,Farnsworth, Christine L,Oka, Richard,Chambers, Reid C,Dwek, Jerry,Kim, Jung Ryul,Perry, Andrew,Mahar, Andrew T Journal of Bone and Joint Surgery 2008 Journal of bone and joint surgery Vol.90 No.12
<P>BACKGROUND: Spinal growth modulation by tethering the anterolateral aspect of the spine, as previously demonstrated in a nonscoliotic calf model, may be a viable fusionless treatment method for idiopathic scoliosis. The purpose of the present study was to evaluate the radiographic, histologic, and biomechanical results after six and twelve months of spinal growth modulation in a porcine model with a growth rate similar to that of adolescent patients. METHODS: Twelve seven-month-old mini-pigs underwent instrumentation with a vertebral staple-screw construct connected by a polyethylene tether over four consecutive thoracic vertebrae. The spines were harvested after six (n = 6) or twelve months (n = 6) of growth. Monthly radiographs, computed tomography and magnetic resonance imaging scans (made after the spines were harvested), histologic findings, and biomechanical findings were evaluated. Analysis of variance was used to compare preoperative, six-month postoperative, and twelve-month postoperative data. RESULTS: Radiographs demonstrated 14 degrees +/- 4 degrees of coronal deformity after six months and 30 degrees +/- 13 degrees after twelve months of growth. Coronal vertebral wedging was observed in all four tethered vertebrae and progressed throughout each animal's survival period. Disc wedging was also created; however, in contrast to the findings associated with vertebral wedging, the tethered side was taller than the untethered side. Magnetic resonance images revealed no evidence of disc degeneration; however, the nucleus pulposus had shifted toward the side of the tethering. Midcoronal undecalcified histologic sections showed intact bone-screw interfaces with no evidence of implant failure or loosening. With the tether cut, stiffness decreased and range of motion increased in lateral bending away from the tether at both time-points (p < 0.05). CONCLUSIONS: In this porcine model, mechanical tethering during growth altered spinal morphology in the coronal and sagittal planes, leading to vertebral and disc wedging proportional to the duration of tethering. The resulting concave thickening of the disc in response to the tether was not anticipated and may suggest a capacity for the nucleus pulposus to respond to the compressive loads created by growth against the tether.</P>
5-(4-Hydroxyphenethenyl)-4,7-dime-thoxycoumarin, a New Constituent of Monotes engleri
Seo, Eun-Kyoung,Chai, Hee-Byung,Chagwedera, Tangai E.,Farnsworth, Norman R.,Cordell, Geoffrey A.,Pezzuto, John M.,Kinghorn, A. Douglas 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9
A new coumarin, 5-(4-hydroxyphenethenyl)-4,7-dimethoxycoumarin (1) was isolated from the combined ethyl acetate extracts of the root bark, root wood and stem bark of Monotes engleri, and found to be cytotoxic against two cell lines in a human tumor panel. Its structure was determined on the basis of spectroscopic methods.
New bioactive aromatic compounds from Vismia guianensis
Seo, Eun-Kyoung,Wani, Mansukh C.,Wall, Monroe E.,Navarro, Hernan,Mukherjee, Rabindranath,Farnsworth, Norman R.,Kinghorn, A. Douglas 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9
Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl_3 extract of the roots of Vismia guianensis by bioassay-directcd fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic.
Macharistol, a New Cytotoxic Cinnamylphenol from the Stems of Machaerium aristulatum
Seo, Eun-Kyoung,Kim, Nam-Cheol,Mi, Qiuwen,Chai, Heebyung,Wall, Monroe E.,Wani, Mansukh C.,Navarro, Herna´n A.,Burgess, Jason P.,Graham, James G.,Cabieses, Fernando,Tan, Ghee T.,Farnsworth, Norman R.,P 梨花女子大學校 藥學硏究所 2001 藥學硏究論文集 Vol.- No.10
A new clnnamylphenol, machaistol(1), along with a known pterocarpan, (+)-medicarpin(2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain(3), and a known isoflavone, formononetin(4), were identified as inactive constituents. Compound 1 was eveluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest does(25 mg/kg body weight) tested.
Bioactive Prenylated Flavonoids from the Stem Bark of Artocarpus kemando
Seo, Eun-Kyoung,Lee, Dong-Ho,Shin, Young-Geun,Chai, Hee-Byung,Navarro, Hernan-A.,Kardono, Leonardus B.S.,Wani, Mansukh, C.,Rahman, Ismail,Cordell, Geoffrey-A.,Farnsworth, Narman-R.,Pezzuto, John-M.,Ki The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.2
Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassayguided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.