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RISS 인기검색어
- 검색키워드
- 저자 : Farid Saad (검색결과 4 건)
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Farid Saad,Gheorghe Doros,Karim Sultan Haider,Ahmad Haider 대한비뇨의학회 2018 Investigative and Clinical Urology Vol.59 No.6
Purpose: To analyze data from an observational, prospective, cumulative registry study in 805 hypogonadal men stratified by mild or moderate-to-severe lower urinary tract symptoms (LUTS) according to International Prostate Symptom Score. Materials and Methods: A total of 412 men underwent testosterone therapy (TTh) with injectable testosterone undecanoate, 393 men served as untreated controls. Measures of urinary function, anthropometric and metabolic parameters were performed at least twice per year. Results: Data from 615 men with mild LUTS (253 treated, 362 untreated) and 190 with moderate-to-severe LUTS (159 treated, 31 untreated) were available. During a follow-up period of 8 years a significant improvement of LUTS was noted for all TTh-patients whereas the control-groups showed deterioration or fluctuation around initial values. Despite advancing age, TTh fully prevented worsening of symptoms. In parallel, a considerable improvement of anthropometric parameters, lipids and glycemic control, blood pressure, C-reactive protein, and quality of life was found. Moderate-to-severe LUTS was associated with worse cardiometabolic risk profile at baseline as well as worse cardiovascular outcomes during follow-up in comparison to mild LUTS. Effect size of TTh was more pronounced in men with moderate-to-severe than with mild LUTS. Conclusions: Correcting hypogonadism by TTh is highly effective and safe for improving LUTS in hypogonadal men. TTh may also improve cardiometabolic risk and major adverse cardiovascular events.
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Late Onset Hypogonadism and Lower Urinary Tract Symptoms: New Insights
Farid Saad,Louis J Gooren 대한남성과학회 2011 The World Journal of Men's Health Vol.29 No.1
Late onset hypogonadism was originally perceived as an academic topic. In the course of two decades it has become an issue impacting on everyday urology. For long time clinical conditions, such as cardiovascular disease, diabetes mellitus type 2, sexual dysfunction and urological complaints affecting the aging male, were regarded as independent clinical entities, treated by a number of medical specialists. Over the last decade their close interrelationship could be convincingly demonstrated. Declining testosterone levels in elderly appear to be central to the above pathologies. Epidemiological studies show that prostate disease occurs at an age when serum testosterone levels decline. It is now clear that erectile dysfunction is a local expression of endothelial dysfunction of the cardiovascular system. Testosterone deficiency is associated with an increased incidence of cardiovascular disease and diabetes mellitus, sequels of the metabolic syndrome. There is a relationship between the metabolic syndrome and lower urinary tract symptoms (LUTS). The pathophysiology of LUTS has much in common with the pathological substrate of erectile dysfunction with regard to vascular factors and the role of nitric oxide, explaining why phosphodiesterase type 5 inhibitors have often a beneficial effect on LUTS. It must be regarded an omission not to include testosterone measurements in the work-up of the LUTS, erectile dysfunction, cardiovascular disease and diabetes mellitus type 2. These conditions hinge on testosterone deficiency, and if testosterone deficiency can be proven, testosterone treatment can improve these conditions. There are many sites in the lower urinary tract where testosterone exerts effects.
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Farid Saad,Aksam Yassin,Ahmad Haider,Gheorghe Doros,Louis Gooren 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.4
Purpose: To investigate the potential benefits of testosterone administration to elderly men (>65 years) with late-onset hypogonadism (LOH) in comparison with younger men and to assess the safety of testosterone administration to elderly men. Materials and Methods: A total of 561 hypogonadal men from two registry studies were divided into age groups of ≤65 years (group Y, n=450; range, 32–65 years) and >65 years (group O, n=111; range, 66–84 years). Following an initial 6-week interval, all men were treated with 3-month injections of parenteral testosterone undecanoate for up to 6 years. Results: Over the 6 years, there was a progressive decrease of body weight and waist circumference. Beneficial effects on lipids and other metabolic factors and on psychological and sexual functioning progressed over the first 24 to 42 months and were sustained. Rather than a deterioration, there was an improvement of urinary parameters. Prostate volume and prostate-specific antigen increased moderately. Hematocrit levels increased but remained within safe margins. Conclusions: The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins. Age itself need not be a contraindication to testosterone treatment of elderly men with LOH.
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M. Faisal,M.M. Alam,Jahir Ahmed,Abdullah M. Asiri,S.A. Alsareii,Raja Saad Alruwais,Norah Faihan Alqahtani,Mohammed M. Rahman,Farid A. Harraz 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.118 No.-
Herein, a facile L-lactic acid electrochemical sensor based on Pt-nanoparticles (NPs)@Chitosan/ZnTiO3nanocomposites (NCs) coated on a glassy carbon electrode (GCE) is demonstrated. Ultra-sonicationmethod followed by irradiation using an Osram Hg-lamp was applied to prepare Pt-NPs@Chitosan/ZnTiO3 NCs, and the characterization of prepared NCs was executed by Field Emission ScanningElectron Microscopy FESEM, Energy Dispersive Spectroscopy EDS, Transmission Electron MicroscopyTEM, High Resolution Transmission Electron Microscopy HRTEM, Fourier Transform InfraredSpectroscopy FTIR, Ultraviolet–visible spectroscopy UV–vis., and X ray Diffraction XRD analysis. A linearcurrent versus potential responses relation was obtained in a concentration range of L-lactic acid of 0. 30 2.40 mM at differential pulse voltammetric (DPV) analysis in a pH 7.0 buffer medium and resultedconcentration range was defined as the dynamic detection range (LDR) for L-lactic acid analysis. The Llacticacid sensor sensitivity (0.4529 lAlM-1cm2), limit of detection (LOD; 22.36 ± 1.12 lM), and limitof quantification (LOQ; 79.88 lM) were obtained. Besides this, the sensor reproducibility and responsetime were found to be reliable. Finally, the assembled sensor probe was validated by the testing of realsamples, which exhibited acceptable and satisfied results. It is introduced a new route for the detection ofchemicals using novel nanocomposite materials by electrochemical approach for the safety of healthcarefields in a broad scales.
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