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Faiz Ur Rahman,You-Rim Kim,Su Jin Kim,Ho-Young Lee,Hyoung-Chin Kim,Ki-Hoan Nam 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Topoisomerases are crucial for solving DNA topological problems by making transient single-strand DNA or double-strand DNA nick. Topoisomerase IIIβ (Top3β) a member of topoisomerase family of enzymes and a major topoisomerase with dual-activity associated with neurodevelopment and mental dysfunction. The aim of this study was to examine the brain connectivities associated with behavioral alteration of Top3β mutant mice. We generated Top3β mutant (Top3β-/-) mice and determined behavioral characteristics of the mutant mice using an animal phenotype analysis platform which included open field test, grip strength, light-dark box, rota-rod, forced swim, Y-maze, fear conditioning and acoustic startle/prepulse inhibition analysis. Brain functional connectivity was also analyzed by PET/CT with [18F] fluorodeoxyglucose technique. Top3β-/- mice shows decreased anxiety/depression-like behaviors and circadian activity in several tests. Altered neuromuscular functions was also observed in Top3β deficient mice. Notably, the expression of Top3β was recognized clearly in the central nervous system, suggesting its role in controlling behavioral phenotype in mice. The functional brain imaging analysis revealed that several brain regions associated with neurodevelopmental and psychiatric disorders of mutant Top3β mice. The Top3β mutation induced significant changes in mouse behavior, which might be mediated by alterations in connectivity of its brain regions. These findings could provide a useful guide of brain disorders specific to Top3β mutation.
Rxfp2, an Insl3 receptor might be associated with the failure of spermatogenesis in Phf7 ko mice
Jieun Kim,Eun-Kyoung Kim,Hae-Rim Kim,Sang-Mi Cho,Danbi Ka,Hoyoung Ghang,Seulgi Park,Mini Lee,Faiz Ur Rahman,Ki-Hoon Lee,Won-Kee Yoon,Young-Suk Won,Hyoung-Chin Kim,Kyoung-Chul Choi,Ki-Hoan Nam 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
PHD finger protein 7 (Phf7) is a member of the PHF family, which contain the PHD domain known as a histone methylation reader and RING domain known as a E3 ubiquitin ligase. Phf7 is expressed testis, specifically in germ cells and Leydig cells but not in Sertoli cells. The deficiency of Phf7 induces male infertility. And it was found that Phf7 acts as a histone H2A E3 ligase in histone-to-protamine exchange during spermatogenesis. Until now, most studies on Phf7 have been focused on spermatogenesis. Here, we tried to found any phenotypes other than male infertility in the Phf7 Ko mice. We found that there are growth-retardation and reduction of bone mineral density in Phf7 knockout (ko) mice. We also tried to found any mechanism that may associated with abnormal spermatogenesis in the Phf7 ko mice. It is known that Rxfp2 is expressed in the postmeiotic germ cells in testis and that Rxfp2 with Insl3, a hormone released from Leydig cells constitute a paracrine hormone-receptor system in testis. Therefore, we determined the expression level of Insl3 and Rxfp2 in testis of Phf7 ko mice. We found that the Insl3 mRNA level was higher in the ko mice, but the Rxfp2 mRNA expression level was reduced in the mutant mice then wild mice. In conclusion, we suggest that the failure of spermatogenesis observed in Phf7 ko mice might related with the reduced expression of Rxfp2 in the developing germ cells.
The sex and age dependant differences in ECG values in C57BL6/N mice
Danbi Ka,Jieun Kim,Eun-Kyoung Kim,Hae-Rim Kim,Sang-Mi Cho,Seulgi Park,Faiz Ur Rahman,Mini Lee,Ki-Hoon Lee,Hoyoung Ghang,Won-Kee Yoon,Young-Suk Won,Hyoung-Chin Kim,Kyoung-Chul Choi,Ki-Hoan Nam 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Eelectrocardiogram (ECG) is a surface recording of the electric current passing through the heart, revealing the electrical activity associated with each heartbeat, and allowing visualization of the electrical state of the heart. In a state of consciousness, normal rat heart rates range from 500 to 700 beats per minute (bpm). ECG reflects the cycle of the heart and consists of P, Q, R, S and T waves. The non-invasive ECG system has the advantage of acquiring information not only on heart rate, but also on heart rate variability, RR, QT and PR intervals, as well as acquiring cardiac abnormalities in conscious animals. In this study, we conducted experiments ECG analysis with 12 weeks and 56 weeks aged male and female C57BL/6N mice. We compared the ECG values between male and female mice and between 12 weeks and 56 weeks aged mice, comparing age and gender differences. There were sex differences in HR and RR in 12 weeks aged mice and in HR and QRS in 56 weeks aged mice. We also found age dependant differences in QRS, ST, HR and RR in male mice and in PR, ST and QTc in female mice. These result indicate that there is age and sex differences in ECG values.