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Effects of Polycyclic Aromatic Hydrocarbons on Liver and Lung Cytochrome P450s in Mice
JiYoungKim,SangKyuLee,ChunHwaKim,TaeWonJeon,문창규,Hye-SookLee,SunDongYoo,EungSeokLee,TaeCheonJeong 대한약학회 2003 Archives of Pharmacal Research Vol.26 No.5
Certain polycyclic aromatic hydrocarbons (PAHs) have been reported to induce cytochrome P450 (CYP) 1A1 and 1A2. In the present study, the effects of six well-known PAHs, such as benzo[a]pyrene, benz[a]anthracene, dibenz[a,h]anthracene, chrysene, benzo[k]fluorancene and benzo[b]fluorancene, on the activities of hepatic and pulmonary CYP enzymes were investigated in male ICR mice. When mice were treated intraperitoneally with 3, 10 and 30 mg/ kg of individual PAHs for 3 consecutive days, the activities of ethoxyresorufin- and methoxyresorufin- O-dealkylases were significantly and differentially induced in both liver and lung. Moreover, other CYP isozyme-associated monooxygenase activities were also induced significantly in liver and lung with characteristic induction profiles. Our present results suggest that individual PAHs might have inductive effects on CYP isozymes, and that the characteristic inductive effects of individual PAHs on certain CYP isozymes would be developed as a marker for determining exposure to certain PAHs.
Effects of aqueous extracts from Lonicera japonica and Tussilago farfara on RAW 264.7 Macrophages
( Eung Seok Lee ),( Su Young Yang ),( Yang Chun Park ),( Young Seon Oh ),( Jin Woo Lee ),( Yong Koo Lee ) 대전대학교 한의학연구소 2010 한의학연구소 논문집 Vol.19 No.1
Inhalational drug is an attractive modality for local therapy of pulmonary diseases as well as systemic drug delivery. Flower of Lonicera japonica (FLJ) and flower of Tussilag farfara (FTP) are medicinal herbs for respiratory disease in traditional Korean medicine. As a preliminary study for effective inhalable formulation of FLJ and FTP, this study was to provide the toxicity and anti-inflammatory effect on murine macrophages. The dried FLJ and FTF were extracted with distilled water, filtered and freeze-dried. After treatment with FLJ and FTF extract on RAW 264.7 cells, the cell viabilities were measured by MTT assay. FLJ and FTF did not show cytotoxicity on RAW 264.7 cells. LPS stimulated RAW 264.7 cells were treated with 3 and 30 μg/ml of FLJ or FTF. FLJ and FTF did not inhibit TNT-a and IL-6 secretion in both concentration of treatment. We suggest that FLJ and FTF may be useful drugs for respiratory disease. Future work will focus on the physical characteristics for inhalable formulation.
Case Report : Metastatic malignant melanoma with peritoneal seeding in a young woman: A case report
( Eung Seok Lee ),( Ji Hyun Ahn ),( Taek Sang Lee ),( Hye Won Jeon ) 대한산부인과학회 2014 Obstetrics & Gynecology Science Vol.57 No.3
Malignant melanomas of the uterus, either primary or metastatic, are extremely rare. They can be mistaken as other tumors, such as uterine sarcomas during diagnosis. We describe here the first case of a metastatic melanoma of the uterus with peritoneal seeding in a young woman. It was first diagnosed as a uterine sarcoma from a frozen-section biopsy.