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Eun-Ah Jo(Eun-Ah Jo),Hyung-Rae Han(Hyung-Rae Han),Shan-Shan Wu(Shan-Shan Wu),Jung-Jun Park(Jung-Jun Park) 대한운동학회 2023 아시아 운동학 학술지 Vol.25 No.1
OBJECTIVES The purpose of present study was to analyze the acute effects of exergame on glucose control after glucose ingestion in individuals with pre- and type 2 diabetes. METHODS We enrolled 60 adults with pre-diabetes (Pre-DM, 58.1±9.2 years, n=20) and type 2 diabetes (T2DM, 61.7±9.9 years, n=40). We measured fingertip capillary blood glucose level at 10 min before, 30 min after, 60 min after and 120 min after the 75-g oral glucose tolerance test (OGTT). For the non-exergame control days, participants pursued normal daily activities but refrained from unusual strenuous physical activity. On the exercise days, participants conducted on exergame at 30 min after 75-g OGTT for 30 min. RESULTS Acute exergame reduced the glucose level 60 min, ΔBG30-60 and ΔBG60-120 after glucose ingestion compared to the control trials (p<0.01, p<0.01 and p<0.001 respectively). The cumulative glucose total area under the curve was lower with exergame than under the control condition (p<0.05). CONCLUSION Acute exergame after glucose ingestion can improve hyperglycemia and glycemic excursion.
Jo, Yeseul,Kim, JeongJae,Park, Chul Hwan,Lee, Jae Wook,Hur, Jee Hye,Yang, Dong Hyun,Lee, Bae Young,Im, Dong Jin,Hong, Su Jin,Kim, Eun Young,Park, Eun-Ah,Kim, Pan Ki,Yong, Hwan Seok Korean Society of Magnetic Resonance in Medicine 2019 Investigative Magnetic Resonance Imaging Vol.23 No.4
Cardiac magnetic resonance (CMR) imaging is widely used in many areas of cardiovascular disease assessment. This is a practical, standard CMR protocol for beginners that is designed to be easy to follow and implement. This protocol guideline is based on previously reported CMR guidelines and includes sequence terminology used by vendors, essential MR physics, imaging planes, field strength considerations, MRI-conditional devices, drugs for stress tests, various CMR modules, and disease/symptom-based protocols based on a survey of cardiologists and various appropriate-use criteria. It will be of considerable help in planning and implementing tests. In addressing CMR usage and creating this protocol guideline, we particularly tried to include useful tips to overcome various practical issues and improve CMR imaging. We hope that this document will continue to standardize and simplify a patient-based approach to clinical CMR and contribute to the promotion of public health.
Mechanisms of IL‐8 suppression by <i>Treponema denticola</i> in gingival epithelial cells
Jo, Ah‐,ram,Baek, Keum Jin,Shin, Ji Eun,Choi, Youngnim Nature Publishing Group 2014 Immunology and Cell Biology Vol.92 No.2
<P>The purpose of this study was to investigate the mechanism(s) of interleukin (IL)‐8 suppression by <I>Treponema denticola</I>, one of the major periodontal pathogens, in gingival epithelial cells. Immortalized human gingival epithelial HOK‐16B cells were infected with wild‐type (WT), dentilisin‐deficient (K1) or flagellin‐deficient (<I>flgE</I>) <I>T. denticola</I> in the presence or absence of 2% human serum for 24 h. The levels of IL‐8 expression were measured with real‐time reverse transcription PCR and ELISA. In the absence of human serum, the WT and <I>flgE</I>, but not K1, substantially reduced not only the levels of IL‐8 protein but also of IL‐8 mRNA. Such downregulation of IL‐8 mRNA was independent of bacterial invasion. Degradation of cytokine mixture by the WT, K1 and <I>flgE</I> revealed dentilisin‐dependent preferential degradation of tumor necrosis factor (TNF)‐α, an IL‐8‐inducing cytokine. WT and <I>flgE</I> significantly decreased the levels of TNFα secreted by HOK‐16B cells, suggesting modulation of IL‐8 through dentilisin‐mediated degradation of TNFα. The addition of human serum to the culture potentiated the suppressive effect of <I>T. denticola</I>, resulting in substantial reductions of IL‐8 and TNFα levels, even by K1. The serum‐dependent effects of <I>T. denticola</I> were attributed to its ability to suppress the accumulation of intracellular reactive‐oxygen species (ROS), a group of ubiquitous signaling molecules. Pretreatment with an antioxidant suppressed TNFα‐induced IL‐8 expression, confirming the role of ROS in TNFα signaling. Collectively, <I>T. denticola</I> targeted a key inflammatory cytokine and its signaling molecule to modulate the host innate immune response, which provides a new insight into modulation of host immunity by a periodontal pathogen.</P>
Factors Influencing Glucose Response to Exercise Following Oral Glucose Load
Eun-Ah Jo,Hyung-Rae Han,Bo-Hyun Kim,Nam-Beom Kim,Shan-Shan Wu,Jung-Jun Park 한국운동생리학회 2023 운동과학 Vol.32 No.4
PURPOSE: Exercise can reduce postprandial hyperglycemia by increasing contraction-mediated glucose uptake in skeletal muscles. However, postprandial exercise does not always have similar effects in all patients. This study aimed to analyze the factors influencing glucose response to exercise following oral glucose load. METHODS: We enrolled 169 adults with impaired glucose tolerance (IGT, n=64) and type 2 diabetes (T2D, n=105). We measured fingertip capillary blood glucose level at 30-minute intervals over 2-hour after the 75-g oral glucose ingestion. In addition, a single bout of moderate-intensity aerobic exercise was conducted at 30 minutes after 75-g oral glucose ingestion. We also measured glycated hemoglobin (HbA1c), insulin, insulin resistance (HOMA-IR), β-cell function (HOMA-β), physical activity level questionnaire and anthropometrics. RESULTS: There was a significant difference in glucose concentration between the IGT and T2D groups (p<.001). Additionally, we found that patients with short diabetes duration (≤1 year) had significantly more decrease in glucose concentration than long diabetes duration (≥10 years) (p<.001). A regression analysis showed that waist circumference, visceral fat area, fasting glucose, HbA1c, and HOMA-IR affected glucose response to exercise following oral glucose load in patients with T2D. CONCLUSIONS: Higher volumes of exercise following an oral glucose load may be necessary for individuals with Type 2 Diabetes (T2D) who have a longer disease duration, larger waist circumference, increased visceral fat area, higher HbA1c levels, and elevated HOMA-IR values in order to prevent hyperglycemia.
Jo, Hannae,Baek, Sora,Park, Hee-won,Lee, Sang-Ah,Moon, Jiyoung,Yang, Jae E.,Kim, Ki Sung,Kim, Jee Yong,Kang, Eun Kyoung JAPAN EPIDEMIOLOGICAL ASSOCIATION 2016 Journal of epidemiology Vol.26 No.1
<P>Background: The ongoing Farmers' Cohort for Agricultural Work-related Musculoskeletal Disorders (FARM) study was developed to evaluate health status and related factors in farmers. Methods: Farmers in Kangwon Province, South Korea, were recruited. Baseline characteristics were determined using questionnaires about sociodemographic and health characteristics and agricultural work-related factors. In addition, laboratory examinations (lumbar spinal radiography and serologic testing) were conducted. Results: The FARM study covers eight rural areas and recruited 1013 subjects (534 women; mean [standard deviation {SD}] age, 57.2 [7.5] years). Musculoskeletal pain in multiple areas was reported by 925 subjects (91.3%), and low back pain (63.8%) was the most frequent site of pain. Farmer's Stress Inventory (mean [SD], 77.7 [10.2]; range, 28-112] and subjective stress index (mean [SD], 5.3 [2.4]; range, 0-10) were above median scale values, reflecting a stressful condition, while the EuroQol-5D-3L index and the EuroQol-Visual Analog Scale scores were high (mean [SD], 0.9 [0.1]; range -0.171-1 and mean [SD], 67.7 [18.7]; range 0-100, respectively), reflecting good life quality. In total, 53% of participants had worked in farming for more than 30 years, and workers involved in dry-field farming comprised the largest subgroup (41.5%). Most participants (94.3%) had no more than a high school education, and families with annual income below 20 million won constituted the largest subgroup (36.3%). Conclusions: The FARM study may provide data on the current health status and related sociodemographic and agricultural work-related risk factors in Korean farmers, with the goal of providing a scientific basis for developing coping interventions and preventive strategies.</P>
Eun Young Park,Bo Ram Jeon,Su Ah Jo,Soo Jin Lee,Kee Young Han,Bong Soo Noh,Kenji Sato 한국산업식품공학회 2018 학술대회 및 심포지엄 Vol.2018 No.04
The objectives of the present study were to examine the antioxidant activity of fractions with different isoelectric points from salmon enzymatic hydrolysates and obtain peptide fractions of sufficient amounts with higher antioxidant peptide fraction, which could be applied to the food and animal model systems. The salmon enzymatic hydrolysates were fractionated on the basis of the amphoteric nature of sample peptides by preparative isoelectric focusing without toxic solvents and reagents, which is termed autofocusing. Acidic and basic fractions showed higher 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity than the other fractions. The basic fractions showed higher hydroxyl (OH) radical scavenging activity. The weak acidic and weak basic fractions showed higher oxygen radical absorbance capacity (ORAC) values than the acidic and basic fractions. The acidic fraction showed higher metal chelating activity than other fractions. The acidic fraction suppressed lipid oxidation in the cooked patties to a greater extent than other fractions. These results suggest that peptides fractions from salmon enzymatic hydrolysate are effective antioxidant, and that autofocusing could be useful to increase antioxidant activity for application to food and animal model systems.
Jo Kyeong Ah,Kim Kyeong Jin,Park Soo-yeon,Jeon Jin-Young,Hwang Ji Eun,Kim Ji Yeon 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.4
In this study we evaluated the immune-enhancing effects of β-glucan, the main component of Euglena gracilis (Euglena), and Euglena on inflammatory factor expression in RAW264.7 macrophages and ICR mice with cyclophosphamide-induced immunosuppression. Macrophages were treated with βglucan or Euglena for 48 h. The β-glucan and Euglena groups exhibited higher levels of inducible nitric oxide synthase, nitric oxide, and tumor necrosis factor (TNF)-α than the control (vehicle alone) group. Animals were fed saline and β-glucan (400 mg/kg body weight (B.W.)) or Euglena (400 or 800 mg/kg B.W.) for 19 days, and on days 17–19, cyclophosphamide (CCP, 80 mg/kg B.W.) was administered to induce immunosuppression in the ICR mouse model. CCP reduced the body weight, spleen index, and cytokine expression of the mice. To measure cytokine and receptor expression, splenocytes were treated with concanavalin A (ConA) or lipopolysaccharide (LPS) as a mitogen for 24 h. In vivo, ConA stimulation significantly upregulated the expression of interferon (IFN)-γ, interleukin (IL)-10, IL-12 receptor β1, IL-1β, and IL-2 in splenocytes from the β-glucan- or Euglena-treated groups compared with those in the splenocytes from the CCP-treated group; LPS stimulation increased the levels of the cytokines TNF-α, IL-1β, and IL-6 in splenocytes from the β-glucan- or Euglena- treated groups compared with those from the CCP-treated group, but most of these differences were not significant. These results demonstrate the effect of Euglena in ameliorating macrophages and immunosuppression in CCP-treated mice. Thus, Euglena has the potential to enhance macrophageand splenocyte- mediated immune-stimulating responses.
Eun-Ah Jo,Kwang Woo Choi,Ahram Han,Sanghyun Ahn,Sang-Il Min,Hwan Jun Jae,Myungsu Lee,Seung-Kee Min 대한혈관외과학회 2021 Vascular Specialist International Vol.37 No.4
Traditional treatment with anticoagulation in nonfatal submassive pulmonary embolism can result in serious sequelae of chronic thromboembolic pulmonary hypertension or poor exercise tolerance, and functional impairment. To prevent long-term complications in previously healthy young patients, other treatment options to actively resolve existing thrombi should be considered. Despite recommendations for use in only severe clinical presentations, endovascular interventional techniques could serve as suitable treatment options for such patients. Here we report the case of a previously healthy 23-year-old female with submassive pulmonary embolism and extensive deep vein thrombosis in the inferior vena cava down to the right popliteal vein. The patient was initially treated with catheterdirected thrombolysis. However, she continued to show extensive venous thrombosis and pulmonary embolism. Percutaneous thrombectomy and aspiration using an AngioJet successfully removed the main pulmonary artery embolism and venous thrombus. The patient’s recovery was uneventful, and 3-month follow-up showed no signs of recurrence or discomfort.