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정필두,김은정,엄민식,서정원,윤석중,김종석,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2
연구목적: TNF-α는 일부 종양의 종양화 과정과 관련이 있는 것으로 알려져 있다. 본 연구는 TNF-α 발현에 영향을 미치는 TNF-α 촉진자 -308 부위의 유전적 다형성이 방광암과 관련이 있는지 유무를 알고자 시행하였다. 대상 및 방법: 유전자 분석을 위하여 환자 113명 및 대조군 109명으로부터 혈액을 채취하여 genomic DNA를 분리한 후 PCR-RFLP 및 direct DNA sequencing을 통하여 TNF-α유전자의 다형성을 조사하여 방광암의 발생, 병기 및 분화도와 비교 검토하였다. 결과: TNF-α 촉진자 -308 부위의 유전형은 대조군에서는 GG형이 83.5%(90례 및 GA형이 16.5%(19례)로 관찰되었으며 AA형은 없었다. 환자군에서는 GG 형이 85.4%(97례), GA형 및 AA형은 각각 13.1%(15례)및 0.8%(1례)에서 관찰되었다. 두 군 모두에서 GG형이 가장 많이 나타났으며 다음으로 GA형을 보이고 AA형은 1례의 방광암 환자에서만 관찰되었다. -308부위의 경우도 두 군 사이에 유전자형의 차이는 없었다(p=0.259) 분화도별 분포를 보면 grade I이 20례, grade II가 49례, grade Ⅲ은 34례였고 병기별로 표재성인 경우가 90례였으며 침윤성은 14례였다. 분화도가 나빠질수록 GA형이 증가하였다(p=0.04). 그러나 병기와 TNF-α promoter -308부위의 유전자형 사이에는 유의한 상관 관계가 없었다(p=0.123). 결론: 방광암 환자의 혈액에서 GA genotype이 관찰되는 경우, 분화도가 나쁠 가능성이 매우 높기 때문에 좀 더 적극적인 치료와 세밀한 추적관찰을 함으로써 방광암으로 인한 사망과 암의 진행을 예방할 수 있을 것으로 기대한다. Purpose : Tumor necrosis factor-alpha (TNF-α) is involved in tumorigenesis of several cancers as an endogenous tumor promoter. The purpose of this study was to investigate whether genetic polymorphism of TNF-α promoter region (-308) was associated with human bladder tumor. Materials and Methods: The DNA from 113 and 109 respective blood samples of bladder tumor Patients and control group was analyzed by PCR-based restriction fragment length polymorphism (RFLP) and direct DNA sequencing methods to characterize the genetic polymorphism of -308 promoter region of the TNF-α gene in bladder tumor patients. We compared the association of bladder tumor with genetic Polymorphism of TNF-α promoter region(-308) in relation to the stage, grade, recurrence and progressio. Results : Eighty-six percents(97/113) of bladder tumor patients and 83.5% (90/109) of control group showed genotype GG at -308 region of TNF-α. Difference in genetic variations of TNF-α promoter (-308) did not exist between bladder tumor patients and control group(p=0.259). Tumor grade was significantly related to the GA genotype (p=0.04). The higher is the grade in bladder tumor, the more frequent was the GA genotype. Tumor stage, recurrence and progression were not significantly associated with genetic polymorphism of TNF-α promoter region (-308). Conclusion: The GA genotype of TNF-a promoter region (-308) had a significant impact on TNF-α production and was related to higher grade tumor compared to GG genotype. TNF-α serum levels in bladder tumor patients were significantly higher than controls. These data suggested that TNF-α might involve the tumorigenesis of the bladder rather than treatment or prevention of bladder tumor.
Eum, Won Sik,Shin, Min Jea,Lee, Chi Hern,Yeo, Hyeon Ji,Yeo, Eun Ji,Choi, Yeon Joo,Kwon, Hyun Jung,Kim, Duk-Soo,Kwon, Oh Shin,Lee, Keun Wook,Han, Kyu Hyung,Park, Jinseu,Kim, Dae Won,Choi, Soo Young Elsevier 2019 Biochimie Vol.156 No.-
<P><B>Abstract</B></P> <P>Parkinson's disease (PD), a neurodegenerative disorder, is characterized by a loss of dopaminergic neurons in the substantia nigra (SN) of the brain and it is well known that the pathogenesis of PD is related to a number of risk factors including oxidative stress. Antioxidant 1 (ATOX1) protein plays a crucial role in various diseases as an antioxidant and chaperone. In this study, we determined whether Tat-ATOX1 could protect against 1-methyl-4-phenylpyridinium ion (MPP<SUP>+</SUP>)-induced SH-SY5Y cell death and in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of PD. In the MPP<SUP>+</SUP> exposed SH-SY5Y cells, Tat-ATOX1 markedly inhibited cell death and toxicities. In addition, Tat-ATOX1 markedly suppressed the activation of Akt and mitogen activated protein kinases (MAPKs) as well as cleavage of caspase-3 and Bax expression levels. In a MPTP-induced animal model, Tat-ATOX1 transduced into brain and protected dopaminergic neuronal cell loss. Taken together, Tat-ATOX1 inhibits dopaminergic neuronal death through the suppression of MAPKs and apoptotic signal pathways. Thus, Tat-ATOX1 represents a potential therapeutic protein drug candidate for PD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Tat-ATOX1 transduces into SH-SY5Y cells and inhibited MPP<SUP>+</SUP>-induced cell death. </LI> <LI> Tat-ATOX1 suppressed the activation of Akt and MAPKs in MPP<SUP>+</SUP> exposed SH-SY5Y cells. </LI> <LI> Tat-ATOX1 inhibited dopaminergic neuronal cell loss in MPTP-induced animal model. </LI> <LI> Tat-ATOX1 represent a potential therapeutic agent for PD. </LI> </UL> </P>
( Min Jea Shin ),( Dae Won Kim ),( Yeon Joo Choi ),( Hyun Ju Cha ),( Sung Ho Lee ),( Sunghou Lee ),( Jinseu Park ),( Kyu Hyung Han ),( Won Sik Eum ),( Soo Young Choi ) 생화학분자생물학회 2020 BMB Reports Vol.53 No.2
Glutaredoxin 1 (GLRX1) has been recognized as an important regulator of redox signaling. Although GLRX1 plays an essential role in cell survival as an antioxidant protein, the function of GLRX1 protein in inflammatory response is still under investigation. Therefore, we wanted to know whether transduced PEP-1-GLRX1 protein inhibits lipopolysaccharide (LPS)- and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced inflammation. In LPS-exposed Raw 264.7 cells, PEP-1-GLRX1 inhibited cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), activation of mitogen activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-κB) expression levels. In a TPA-induced mouse-ear edema model, topically applied PEP-1-GLRX1 transduced into ear tissues and significantly ameliorated ear edema. Our data reveal that PEP-1-GLRX1 attenuates inflammation in vitro and in vivo, suggesting that PEP-1-GLRX1 may be a potential therapeutic protein for inflammatory diseases. [BMB Reports 2020; 53(2): 106-111]
재발성 정맥혈전증을 유발한 Antithrombin 3 와 Protein C 복합 결핍증 1 예
엄민섭(Min Sup Eum),박연희(Yeon Hee Park),설재일(Jae Il Seol),채수엽(Soo Youb Chae),유문빈(Moon Bin You),강기훈(Ki Hoon Kang),이병수(Byung Soo Lee),채은하(Eun Ha Chae),박정식(Jeong Sik Park),정용환(Yong Hwan Jung),안승혜(Seung Hye Ah 대한내과학회 2002 대한내과학회지 Vol.62 No.5
Primary venous thrombosis caused by deficiency or qualitative abnormality of antithrombin III, protein C and protein S is usually inherited as an autosomal dominant trait. Usually, deep vein thrombosis or pulmonary thromboembolism is developed by such abnormalities, however, mesenteric vein thrombosis is rarely reported. A 27-year-old man with previous history of deep vein thrombosis underwent segmental resection of jejunum due to mesenteric vein thrombosis complicated by necrosis of jejunum. Postoperative investigation disclosed combined deficiency of antithrombin III and protein C. His son also showed deficiency of antithrombin III. Postoperatively, he is on life-long warfarin therapy without experiencing recurrence of venous thrombosis.(Korean J Med 62:570-574, 2002)
주현식 ( Hyun Sik Joo ),신주원 ( Joo Won Shin ),김동은 ( Dong Eum Kim ),김대철 ( Dae Cheol Kim ),김성민 ( Seong Min Kim ),이동훈 ( Dong Hun Lee ),조용진 ( Yongjin Cho ) 한국농업기계학회 2022 한국농업기계학회 학술발표논문집 Vol.27 No.1
정밀한 농작물 생육상태 진단 및 수확량 예측 분석 모델을 개발을 위해서는 최적화된 분석 모델개발이 필요하다. 확보한 드론 영상으로 농업 공간정보 구축하고 벼 농작물 생육/작황 상태 모니터링 정보를 가시화 기술이 필요하다. 따라서 본 연구에서는 학습용 데이터 기반하에 AI 플랫폼 구축하는데 있다. AI 학습 데이터 구축을 위해 영상전처리 후의 필지단위 타일링 가공 데이터에 작황정보 현장조사 라벨링 데이터를 업로드하였으며 작물 필지와 그 외 지역 구분을 위한 필지 외곽선 추출작업 진행하였다. 테이블 구성 및 이미지 마스킹에 대한 메타정보를 입력하였다. 작물 및 재배면적 판독을 위한 학습 데이터 구축을 위해 각 재배/수확필지를 구분하여 태깅하였다. 인공지능 데이터 구축에서는 75 : 25 로 비율의 Train set으로 진행하였다. 드론 영상은 일정 크기인 512 x 512픽셀로 그리드 분할하고, 태깅된 데이터는 마스킹 이미지로 변환하여 그리드 분할하였다. 그리드 분할된 이미지와 마스킹 이미지는 학습과 테스트를 위한 데이터로 75 :25 의 비율로 분리하였다. AI 알고리즘을 활용한 농작물 생육상태 진단 및 품질, 수확량 예측 분석 모델 선정하였으며, 최적 분석모델 개발을 위한 Classification & Segmentation + Regression Analysis 모델을 적용하였다. 알고리즘을 바탕으로 선정된 벼 농작물 판독 및 인식 모델인 U-Net 모델 개발을 완료하였다. 딥러닝 기술 기반의 이미지 분할기술 중 Semantic Segmentation 기술을 활용하여 이미지 분할 방법 적용하여 농작물(벼)판독 및 재배면적 산출하였다. 선정된 작물의 품질 및 수확량 예측을 위한 추론 모델인 RESNET 모델을 개발할 예정에 있다.
Chin, Chong Shik,Eum, Min-Sik,Kim, Song yi,Kim, Choongil,Kang, Sung Kwon WILEY-VCH Verlag 2006 European journal of inorganic chemistry Vol.2006 No.24
<P>A new type of iridium(III) complex [trans-Ir(ppy)<SUB>2</SUB>(PPh<SUB>3</SUB>)<SUB>2</SUB>]<SUP>+</SUP> (1) has been prepared by a novel synthetic method and its structural and photoluminescent characteristics have been compared with those of the cis analogue, [cis-Ir(ppy)<SUB>2</SUB>(PPh<SUB>3</SUB>)(P(OPh)<SUB>3</SUB>)]<SUP>+</SUP> (2) which has also been newly prepared in this study. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)</P> <B>Graphic Abstract</B> <P> <img src='wiley_img/14341948-2006-2006-24-EJIC200600888-fig000.gif' alt='wiley_img/14341948-2006-2006-24-EJIC200600888-fig000'> </P>
천연한약재(목통, 삼릉, 치자) 추출물의 항산화효과 및 항균활성효과
김정균,강영미,엄광식,고영민,김태영 경상대학교 농업생명과학연구원 2003 농업생명과학연구 Vol.37 No.4
한약재로 많이 이용되고 있는 목통, 삼릉 및 치자의 항산화활성과 항균활성 정도를 검토하기 위해 한약재를 물, 70% methanol(MeOH) 및 100% MeOH로 추출한 후 각 추출물의 페놀화합물함량, 전자공여능, hydroxy radical 소거효과, reducing power 및 항균활성시험을 하였다. 그 결과 실험에 사용한 3가지 한약재 모두 항산화효과와 항균활성이 뛰어났으며, 특히 목통 70% MeOH 추출물이 그 효과가 가장 컸으며 다음이 100% MeOH, 물추출물 순이었다. Antioxidant activity and antimicrobial activity of medicinal plants extracts from 3 edible or medicinal plant were examined. The extracts from Akebia quinate Decaisne, Scirusfluviatilis A. Gray, Gardenia jasminoides for. grandiflora Makino showed comparatively strong antioxidative activity on test. Electron donatating abilities and hydroxy radical scavenging ablities of 70% methanol, 100% methanol extracts were higher than thoes of water extracts. Some extracts of medicinal plants showed antimicrobial effect, especially, the extracts showed antimicrobial effect in the 70% methanol higher than other extracts.
Effects of PEP-1-FK506BP on cyst formation in polycystic kidney disease
( Hyo Sang Jo ),( Won Sik Eum ),( Eun Young Park ),( Je Young Ko ),( Do Yeon Kim ),( Dae Won Kim ),( Min Jea Shin ),( Ora Son ),( Su Bin Cho ),( Jung Hwan Park ),( Chi Hern Lee ),( Eun Ji Yeo ),( Hyeo 생화학분자생물학회 2017 BMB Reports Vol.50 No.9
Polycystic kidney disease (PKD) is one of the most common inherited disorders, involving progressive cyst formation in the kidney that leads to renal failure. FK506 binding protein 12 (FK506BP) is an immunophilin protein that performs multiple functions, including regulation of cell signaling pathways and survival. In this study, we determined the roles of PEP-1- FK506BP on cell proliferation and cyst formation in PKD cells. Purified PEP-1-FK506BP transduced into PKD cells markedly inhibited cell proliferation. Also, PEP-1-FK506BP drastically inhibited the expression levels of p-Akt, p-p70S6K, p-mTOR, and p-ERK in PKD cells. In a 3D-culture system, PEP-1- FK506BP significantly reduced cyst formation. Furthermore, the combined effects of rapamycin and PEP-1-FK506BP on cyst formation were markedly higher than the effects of individual treatments. These results suggest that PEP-1-FK506BP delayed cyst formation and could be a new therapeutic strategy for renal cyst formation in PKD. [BMB Reports 2017; 50(9): 460-465]