http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Eoh, Jae-Hyuk,Park, Shane,Jeun, Gyoo-Dong,Kim, Moo-Hwan Korean Nuclear Society 2001 Nuclear Engineering and Technology Vol.33 No.2
Under severe accidents, the pressure and temperature response has an important role for the integrity of a nuclear power plant containment. The history of the pressure and temperature is characterized by the amount and state of steam/air mixture in a containment. Recently, the heat transfer rate to the structure surface is supposed to be increased by the wavy interface formed on condensate film. However, in the calculation by using CONTAIN code, the condensation heat transfer on a containment wall is calculated by assuming the smooth interface and has a tendency to be underestimated for safety. In order to obtain the best- estimate heat transfer calculation, we investigated the condensation heat transfer model in CONTAIN 1.2 code and adopted the new forced convection correlation which is considering wavy interface. By using the film tracking model in CONTAIN 1.2 code, the condensate film is treated to consider the effect of wavy interface. And also, it was carried out to investigate the effect of the different cell modelings - 5-cell and 10-cell modeling - for KNGR(Korean Next Generation Reactor) containment phenomena during a severe accident. The effect of wavy interface on condensate film appears to cause the decrease of peak temperature and pressure response . In order to obtain more adequate results, the proper cell modeling was required to consider the proper flow of steam/air mixture.
Cooperative object transportation using parallel line formation with a circular shift
Eoh, Gyuho,Jeon, Jae D.,Oh, Jung H.,Lee, Beom H. Cambridge University Press 2017 Robotica Vol.35 No.6
<B>SUMMARY</B><P>This paper presents a new cooperative object transportation technique using parallel line formation with a circular shift. Typical areas of research in relation to object transportation are grasping, pushing, and caging techniques, but these require precise grasping behaviors, iterative motion correction according to the object pose, and the real-time acquisition of the object shape, respectively. In this paper, the proposed technique does not need to consider the shape or the pose of objects, and equipped tools are not necessary for object transportation because objects are transported by pushing behavior only. Multiple robots create parallel line formation using a virtual electric dipole field and then push multiple objects into the formation. This parallel line is extended to the goal using cyclic motion by the robots and the objects are transported to the goal by pushing behavior. The above processes are decentralized and activated based on the finite state machine of each robot. Simulations and practical experiments are presented to verify the proposed technique.</P>
Eoh, Kyung Jin,Paek, Jiheum,Kim, Sang Wun,Kim, Hee Jung,Lee, Hye Yeon,Lee, Sang Kil,Kim, Young Tae NATIONAL HELLENIC RESEARCH FOUNDATION 2017 Oncology Reports Vol.38 No.6
<P>Contemporary research has focused on the function of long non-coding RNAs (lncRNAs) in carcinogenesis. However, the involvement of the lncRNA, steroid receptor RNA activator (SRA), in cervical carcinogenesis remains to be elucidated. In the present study, we investigated the bio-functional consequences of lncRNA SRA knockdown <I>in vitro</I>. To verify the role of lncRNA SRA in cell proliferation, migration, and invasion, lncRNA RNA interference was utilized to knock down lncRNA SRA expression in cervical cancer cell lines, resulting in our discovery that lncRNA SRA knockdown inhibited cell proliferation, cell migration and tumor invasion in the cervical cancer cell lines. Additionally, <I>in vitro</I> experiments using the lncRNA SRA-knockdown cervical cancer cell lines revealed that lncRNA SRA is a strong inducer and modulator of the expression of genes related to epithelial-mesenchymal transition and the NOTCH signaling pathway. In conclusion, our findings demonstrated that lncRNA SRA is highly correlated with cancer progression and cervical cancer cell proliferation and migration. Furthermore, these results indicate that lncRNA SRA may be a potential therapeutic target and prognostic marker for cervical malignancy.</P>
Eoh, Kyung Jin,Kim, Ji Eun,Park, Hyung Seok,Lee, Seung-Tae,Park, Ji Soo,Han, Jung Woo,Lee, Jung-Yun,Kim, Sunghoon,Kim, Sang Wun,Kim, Jae Hoon,Kim, Young Tae,Nam, Eun Ji Korean Cancer Association 2018 Cancer Research and Treatment Vol.50 No.3
<P><B>Purpose</B></P><P>Next-generation sequencing (NGS) allows simultaneous sequencing of multiple cancer susceptibility genes and may represent a more efficient and less expensive approach than sequential testing. We assessed the frequency of germline mutations in individuals with epithelial ovarian cancer (EOC), using multi-gene panels and NGS.</P><P><B>Materials and Methods</B></P><P>Patients with EOC (n=117) with/without a family history of breast or ovarian cancer were recruited consecutively, from March 2016 toDecember 2016.GermlineDNAwas sequenced using 35-gene NGS panel, in order to identify mutations. Upon the detection of a genetic alteration using the panel, results were cross-validated using direct sequencing.</P><P><B>Results</B></P><P>Thirty-eight patients (32.5%) had 39 pathogenic or likely pathogenic mutations in eight genes, including <I>BRCA1</I> (n=21), <I>BRCA2</I> (n=10), <I>BRIP1</I> (n=1), <I>CHEK2</I> (n=2), <I>MSH2</I> (n=1), <I>POLE</I> (n=1), <I>RAD51C</I> (n=2), and <I>RAD51D</I> (n=2). Among 64 patients with a family history of cancer, 27 (42.2%) had 27 pathogenic or likely pathogenic mutations, and six (9.3%) had mutations in genes other than <I>BRCA1/2</I>, such as <I>CHECK2</I>, <I>MSH2</I>, <I>POLE</I>, and <I>RAD51C</I>. Fifty-five patients (47.0%) were identified to carry only variants of uncertain significance.</P><P><B>Conclusion</B></P><P>Using the multi-gene panel test, we found that, of all patients included in our study, 32.5% had germline cancer-predisposing mutations. NGS was confirmed to substantially improve the detection rates of a wide spectrum of mutations in EOC patients compared with those obtained with the <I>BRCA1/2</I> testing alone.</P>
Eoh, Kyung Jin,Chung, Young Shin,Lee, So Hyun,Park, Sun-Ae,Kim, Hee Jung,Yang, Wookyeom,Lee, In Ok,Lee, Jung-Yun,Cho, Hanbyoul,Chay, Doo Byung,Kim, Sunghoon,Kim, Sang Wun,Kim, Jae-Hoon,Kim, Young Tae 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3
<P><B>Purpose</B></P><P>Although the use of xenograft models is increasing, few studies have compared the clinical features or outcomes of epithelial ovarian cancer (EOC) patients according to the tumorigenicity of engrafted specimens. The purpose of this study was to evaluate whether tumorigenicity was associated with the clinical features and outcomes of EOC patients. </P><P><B>Materials and Methods</B></P><P>Eighty-eight EOC patients who underwent primary or interval debulking surgery from June 2014 to December 2015 were included. Fresh tumor specimens were implanted subcutaneously on each flank of immunodeficient mice. Patient characteristics, progression-free survival (PFS), and germline mutation spectra were compared according to tumorigenicity.</P><P><B>Results</B></P><P>Xenografts were established successfully from 49 of 88 specimens. Tumorigenicity was associated with lymphovascular invasion and there was a propensity to engraft successfully with high-grade tumors. Tumors from patientswho underwent non-optimal (residual disease ≥ 1 cm) primary orinterval debulking surgery had a significantly greater propensity to achieve tumorigenicity than those who received optimal surgery. In addition, patients whose tumors became engrafted seemed to have a shorter PFS and more frequent germline mutations than patients whose tumors failed to engraft. Tumorigenicity was a significant factor for predicting PFS with advanced International Federation of Gynecology and Obstetrics stage and high-grade cancers.</P><P><B>Conclusion</B></P><P>sTumorigenicity in a xenograft model was a strong prognostic factor and was associated with more aggressive tumors in EOC patients. Xenograft models can be useful as a preclinical tool to predict prognosis and could be applied to further pharmacologic and genomic studies on personalized treatments.</P>