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Prostaglandin F receptor expression in intrauterine tissues of pregnant rats
Elvan Anadol,Halit Kanca,Atiye Seda Yar,Fatma Helvacioğlu,Sevda Menevşe,Engin Ҫalgüner,Deniz Erdoğan 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.1
In this investigation, we studied the expression andlocalization of rat prostaglandin F (FP) receptor in uterinetissues of rats on gestational Days 10, 15, 18, 20, 21, 21.5 andpostpartal Days 1 and 3 using Western blotting analysis,real-time PCR, and immunohistochemistry. A high level ofimmunoreactivity was observed on gestational Days 20, 21,and 21.5 with the most significant signals found on Day 20. FP receptor protein was expressed starting on gestationalDay 15, and a fluctuating unsteady increase was observeduntil delivery. Uterine FP receptor mRNA levels were lowbetween Days 10 and 18 of gestation (p < 0.05). Thetranscript level increased significantly on Day 20 andpeaked on Day 21.5 just before labor (p < 0.05). There wasa positive correlation between FP receptor mRNAexpression and serum estradiol levels (rs = 0.78; p < 0.01)along with serum estradiol/progesterone ratios (rs = 0.79; p < 0.01). In summary, we observed an increase FP receptorexpression in rat uterus with advancing gestation, a markedelevation of expression at term, and a concominant decreaseduring the postpartum period. These findings indicate a rolefor uterine FP receptors in the mediation of uterinecontractility at term.