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RISS 인기검색어
- 검색키워드
- 저자 : Elham Khodaverdi (검색결과 2 건)
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Elham Khodaverdi,Melika Javan,Sayyed A. Sajadi Tabassi,Bahman Khameneh,Hossein Kamali,Farzin Hadizadeh 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.3
Formulating a polypeptide gastrointestinal drug delivery system have been persistent challenges. To overcome these challenges, in situ-forming gels are more attractive because of their biodegradability and easy preparation and administration. In this study, biodegradable triblock copolymer polycaprolactone–polyethylene glycol–polycaprolactone [PCL–PEG–PCL (PCEC)] was synthesized under microwave irradiation and their gelation with different concentrations of a-cyclodextrin (CD) was investigated. PCEC was characterized by 1HNMR and gel permeation chromatography. The hydrogel and copolymer were also evaluated using differential scanning colorimetery, X-ray diffraction study and scanning electron microscopy. Also rheological properties were investigated. Four different concentrations of hydrogels consisting of the copolymer [5 and 7.5% (w/w)] and a-CD [10 and 14% (w/ w)] were studied to evaluate insulin cumulative release profiles during 37 days. Finally, CD spectrum and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDSPAGE) tests were performed to approve the stability of released insulin. It was demonstrated that the synthesis of PCEC via microwave irradiation was fast and efficient. Copolymer and a-CD concentrations are important in forming supramolecular hydrogels. Rheographs indicated the injectability and thixotropic behavior. In vitro release studies affirmed the sustained release profile of insulin. Both polymer degradation and drug diffusion are involved in it. Results of stability tests confirmed the stability of insulin following release.
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Casein-based hydrogel carrying insulin: preparation, in vitro evaluation and in vivo assessment
Farzin Hadizadeh,Bahman Khameneh,Elham Khodaverdi,Sepehr Maftouhian,Ali Aliabadi,Mohammad Hassanzadeh‑Khayyat,Fatemeh Mohammadpour 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.6
Hydrogels show great potential particularly in the development of drug delivery because of their desirable properties. The enzymatic crosslinked casein hydrogel is a new generation and has received great attention for drug delivery. In the present study, the enzymatic crosslinked casein hydrogel containing insulin was prepared and in vitro and in vivo evaluations were assessed. The hydrogels were also evaluated using differential scanning calorimeter; X-ray diffraction; Scanning electron microscopy and Atomic force microscopy methods. The rheological and releasing behaviors at different media were also investigated. The secondary structure of insulin was assayed by CD method and finally, the hypoglycemic effects were tested in the diabetic rats. Hydrogel showed a three-dimensional porous structure. Rheographs indicated the combination of thixotropic and pseudoplastic behaviors. In vitro release studies confirmed that insulin released in acidic condition slowly, however, in neutral and alkaline environments insulin rapidly released. The structure of insulin preserved following release. Hypoglycemic effects were observed by oral administration of insulin-loaded hydrogel. Thus, the enzymatic crosslinked hydrogel can be considered as a good candidate for oral delivery of insulin.
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