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- 저자 : Elham Hoveizi (검색결과 2 건)
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Mohammad Reza Ramezani,Zeinab Ansari-Asl,Elham Hoveizi,Ali Reza Kiasat 한국섬유공학회 2020 Fibers and polymers Vol.21 No.5
Fabrication of nanofibrous scaffolds of biodegradable polymers provides a great premise for several biologicalapplications. In this study, nanofibrous polycaprolactone (PCL) mats incorporating Fe-MOF (PCL/x%Fe-MOF, x=5, 10, 20)were fabricated by electrospinning technique. The Fe-MOFs were separately synthesized by the hydrothermal method andthen were added to PCL solution for preparation of nanofibrous composites. The presence of Fe-MOF in the fibers wasdemonstrated by various methods including FT-IR (Fourier-transform infrared), PXRD (powder X-ray diffraction), EDS(energy dispersive X-ray spectroscopy) mapping, SEM (scanning electron microscope), and TEM (transmission electronmicroscope). In the FT-IR spectra of the nanocomposites, the characteristic bands for the pure PCL and Fe-MOF showed nosignificant change in their positions, suggesting a weak chemical interaction with each other, although they physically mixeduniformly. Nanofibrous structure of the as-prepared nanocomposites was confirmed by SEM and TEM images. The diameterof PCL nanofibers was measured to be 369 nm. Biological investigations indicated that the experimented scaffolds includingPCL/5%Fe-MOF and PCL/10%Fe-MOF nanofibrous scaffolds provided appropriate surface and mechanical properties suchas cellular biocompatibility, high porosity, chemical stability, and optimum fiber diameter for cell adhesion, viability, andproliferation compared with PCL and PCL/20%Fe-MOF nanocomposites. Indeed, our results demonstrated that percent ofFe-MOF in the composites played a significant role in cell attachment and viability. Also, according to the implantationstudies, up to at least 4 weeks, none of the animals showed any inflammatory response. Totally, we can be claimed that themodified electrospun scaffolds have been developed for tissue engineering applications.
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Soghra Nikpour,Zeinab Ansari-Asl,Tahereh Sedaghat,Elham Hoveizi 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.110 No.-
Fabrication of biocompatible scaffolds that can facilitate the mending of damaged tissue has attractedmuch attention. In this study, the preparation and structural investigation of a curcumin-loaded Fe(II)metal–organic framework/polydimethylsiloxane sponge, Cur/Fe-MOF/PDMS, are reported. Various techniquessuch as FTIR (Fourier-transform infrared), XRD (X-ray diffraction), SEM (scanning electron microscope),TEM (transmission electron microscope), EDS (energy-dispersive X-ray spectroscopy) mapping,and XPS (X-ray photoelectron spectroscopy) have been used to investigate the as-fabricated materials. Results confirm the successful incorporation of curcumin and Fe-MOF into the PDMS matrix. Theobtained SEM images indicate the sponge-like structures of the PDMS and the Fe-MOF/PDMS composite. Indeed, the results from in vivo show animals all to be survived without any unusual responses to thetransplant. According to macroscopic observation, the Fe-MOF/PDMS and Cur/Fe-MOF/PDMS scaffoldsseem better confederates than the pure PDMS. H&E staining has confirmed enhanced healing and revascularizationin the Cur/Fe-MOF/PDMS than the PDMS and Fe-MOF/PDMS scaffolds. Additionally, a twostageprofile was observed for the release of curcumin into PBS (phosphate-buffered saline) solution. The hydrophilic property of the Fe-MOF resulted in fast release at the first stage. These results exhibit thatthe Cur/Fe-MOF/PDMS sponge can serve as a 3D porous substrate in the tissue engineering (TE) field.
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