A hybrid genetic–firefly algorithm for engineering design problems

El-Shorbagy M A,El-Refaey Adel M 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.2

Firefly algorithm (FA) is a new random swarm search optimization algorithm that is modeled after movement and the mutual attraction of flashing fireflies. The number of fitness comparisons and attractions in the FA varies depending on the attraction model. A large number of attractions can induce search oscillations, while a small number of attractions can cause early convergence and a large number of fitness comparisons that can add to the computational time complexity. This study aims to offer H-GA–FA, a hybrid algorithm that combines two metaheuristic algorithms, the genetic algorithm (GA) and the FA, to overcome the flaws of the FA and combine the benefits of both algorithms to solve engineering design problems (EDPs). In this hybrid system, which blends the concepts of GA and FA, individuals are formed in the new generation not only by GA processes but also by FA mechanisms to prevent falling into local optima, introduce sufficient diversity of the solutions, and make equilibrium between exploration/exploitation trends. On the other hand, to deal with the violation of constraints, a chaotic process was utilized to keep the solutions feasible. The proposed hybrid algorithm H-GA–FA is tested by well-known test problems that contain a set of 17 unconstrained multimodal test functions and 7 constrained benchmark problems, where the results have confirmed the superiority of H-GA–FA overoptimization search methods. Finally, the performance of the H-GA–FA is also investigated on many EDPs. Computational results show that the H-GA–FA algorithm is competitive and better than other optimization algorithms that solve EDPs.

Monarch butterfly optimization-based genetic algorithm operators for nonlinear constrained optimization and design of engineering problems

El-Shorbagy M A,Alhadbani Taghreed Hamdi 한국CDE학회 2024 Journal of computational design and engineering Vol.11 No.3

This paper aims to present a hybrid method to solve nonlinear constrained optimization problems and engineering design problems (EDPs). The hybrid method is a combination of monarch butterfly optimization (MBO) with the cross-over and mutation operators of the genetic algorithm (GA). It is called a hybrid monarch butterfly optimization with genetic algorithm operators (MBO-GAO). Combining MBO and GA operators is meant to overcome the drawbacks of both algorithms while merging their advantages. The self-adaptive cross-over and the real-valued mutation are the GA operators that are used in MBO-GAO. These operators are merged in a distinctive way within MBO processes to improve the variety of solutions in the later stages of the search process, speed up the convergence process, keep the search from getting stuck in local optima, and achieve a balance between the tendencies of exploration and exploitation. In addition, the greedy approach is presented in both the migration operator and the butterfly adjusting operator, which can only accept offspring of the monarch butterfly groups who are fitter than their parents. Finally, popular test problems, including a set of 19 benchmark problems, are used to test the proposed hybrid algorithm, MBO-GAO. The findings obtained provide evidence supporting the higher performance of MBO-GAO compared with other search techniques. Additionally, the performance of the MBO-GAO is examined for several EDPs. The computational results show that the MBO-GAO method exhibits competitiveness and superiority over other optimization algorithms employed for the resolution of EDPs.

Eco-friendly Chitosan Condensation Adduct Resins for Removal of Toxic Silver Ions from Aqueous Medium

Hadeel G. El-Shorbagy,Salah M. El-kousy,Khalid Z. Elwakeel,M.A. Abd El-Ghaffar 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.100 No.-

A simple and economical method for modifying chitosan based on non-catalytic direct condensationreaction between chitosan and phenolic acids “Gallic and Caffeic acids” has been developed to producecondensation adduct resins RI and RII. The resins structure and morphology were confirmed by physicaland chemical tools such as FTIR, SEM, EDX, XRD elemental analysis, TGA, water regain, dissociation inacidic medium, and point of zero charge. The new resins were evaluated as silver ions adsorbents. Factorsaffecting adsorption, as well as kinetics, equilibrium, and thermal properties of adsorption, were studiedusing conventional equations. The new resins showed more efficient removal of toxic silver ions from theaqueous medium than parent chitosan polymer. The maximum adsorption capacity amounted to 67.5,300, and 278 mg/g with removal efficiency reaching 22.5%, 100%, and 92.66% for chitosan, RI, and RII;respectively at pH 6.5 and initial silver concentration 300 mg/L. The new resins showed spontaneouschemisorption toward silver ions with exothermic nature for RI, and endothermic nature for RII. The newcondensation adduct resins showed good re-use ability reaching 83% and 67% for RI and RII; respectively,by using 0.01 M nitric acid solution.

DNA methylation of GDF-9 and GHR genes as epigenetic regulator of milk production in Egyptian Zaraibi goat

Gamal Layaly,Noshy Magda M.,Aboul-Naga A. M.,Sabit Hussein,El-Shorbagy Haidan M. 한국유전학회 2024 Genes & Genomics Vol.46 No.1

Background DNA methylation is an epigenetic mechanism that takes place at gene promoters and a potent epigenetic marker to regulate gene expression. Objective The study aimed to improve the milk production of Zaraibi goats by addressing the methylation pattern of two milk production-related genes: the growth hormone receptor (GHR) and the growth differentiation factor-9 (GDF-9). Methods 54 and 46 samples of low and high milk yield groups, respectively, were collected. Detection of methylation was assessed in two CpG islands in the GDF-9 promoter via methylation-specific primer assay (MSP) and in one CpG island across the GHR promoter using combined bisulfite restriction analysis (COBRA). Results A positive correlation between the methylation pattern of GDF-9 and GHR and their expression levels was reported. Breeding season was significantly effective on both peak milk yield (PMY) and total milk yield (TMY), where March reported a higher significant difference in PMY than November. Whereas single birth was highly significant on TMY than multiple births. The 3rd and 4th parities reported the highest significant difference in PMY, while the 4th parity was the most effective one on TMY. Conclusion These results may help improve the farm animals' milk productive efficiency and develop prospective epigenetic markers to improve milk yield by epigenetic marker-assisted selection (eMAS) in goat breeding programs.

Synthesis and Anti-Inflammatory Testing of Some New Compounds Incorporating 5-Aminosalicylic Acid (5-ASA) as Potential Prodrugs

Abdel-Alim Mohamed Abdel-Alim,Abdel-Nasser Ahmed El-Shorbagi,Samia Galal Abdel-Moty,Hajjaj Hassan Mohamed Abdel-Allah 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.6

This work includes the synthesis of 15 final compounds (6a-h and 7b-h) as prodrugs of 5-ASA in the form of the acid itself, esters and amides linked by an amide linkage through a spacer to the endocyclic ring N of nicotinamide. Also, 15 new intermediate compounds were prepared. The target compounds (6b, 6f, 7b, and 7e-h) revealed potent analgesic and anti-inflammatory activities in comparison to sulfasalazine and 5-ASA. In addition, ulcerogenicity, LD50, in vivo and in vitro metabolism of compound 7f were determined.

Synthesis of New 4,5-3(2H)pyridazinone Derivatives and Their Cardiotonic, Hypotensive, and Platelet Aggregation Inhibition Activities

Enas Nashaat Amin,Abdel-Alim M. Abdel-Alim,Samia G. Abdel-Moty,Abdel-Naser A. El-Shorbagi,Mahran Sh. Abdel-Rahman 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.1

4,5-dihydro-3(2H)pyridazinones such as CI-914, CI-930 and pimobendan along with tetrahydropyridopyridazine (endralazine) and perhydropyridazinodiazepine (cilazopril) have been used as potent positive inotropes, antihypertensives as well as platelet aggregation inhibitors. Accordingly, the present work involves the synthesis of 24 target compounds; 4,5-dihydro-3(2H)pyridazinones in addition to seven reported intermediates. The chemical structures of the new compounds were assigned by microanalysis, IR, 1H-NMR spectral analysis and some representatives by mass spectrometry. The positive inotropic effect of the final compounds and the intermediates 12a-12d as well as the reported intermediate compound 10 was determined in-vitro on isolated rabbit heart in comparison to digoxin. Data obtained revealed that twelve of the test compounds exhibited higher effective response than digoxin, nine compounds elicited comparable effects to digoxin and eight compounds were less active than digoxin. In addition, four compounds approved marked significant hypotensive effect better than that of the previously reported compound 10. Moreover, two compounds induced complete platelet aggregation inhibition. The last two compounds were also subjected to determination of their LD50 and they showed no signs of toxicity up to the dose level 300 mg/kg (i.p.), while the reported oral LD50 of digoxin is 17.78 mg/kg. Correlation of cardiotonic and hypotensive activities with structures of compounds was tried and pharmacophore models were computed to get useful insight onto the essential structural features required for inhibiting phosphodiesterase-III in the heart muscles and blood vessels.