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Majid Abdouss,Ebadullah Asadi,Saman Azodi-Deilami,Davood Kordestani,Alireza Rahimi,Somayeh Asadi 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.6
We prepared high selective imprinted nanoparticle polymers by a miniemulsion polymerization technique,using risperidone as the template, MAA as the functional monomers, and TRIM as the cross-linker in acetonitrileas solvent. The morphology of the nanoparticles determined by scanning electron microscopy (SEM) images and drugrelease, binding properties and dynamic light scattering (DLS) of molecularly imprinted polymers (MIPs) were studied. Controlled release of risperidone from nanoparticles was investigated through in 1% wt sodium dodecyl sulfate aqueoussolution and by measuring the absorbance by HPLC-UV. The results showed that the imprinted nanoparticles exhibiteda higher binding level and slower release rate than non-imprinted nanoparticles, which contributed to interaction ofrisperidone with imprinted cavities within nanoparticles. Furthermore, the results from HPLC showed good precision(5% for 50.0 g L-1) and recoveries (between 86-91) using MIP from human plasma samples.