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Familial Membranous Lupus Nephritis in Brothers
Earm, Jae-Ho,Lee, Kang-Wook,Ha, Tae-Sun 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.1
전신성 홍반성 낭창의 발병에는 여러가지 원인이 작용하는 것으로 생각되고 있으며, 그 중에서 유전적인 요소도 어느 정도 역할을 할 것으로 생각되고 있다. 이러한 유전적인 발병원인의 증거로서 일란성 쌍둥이 및 가족적으로 전신성 홍반성 낭창이 발병한 증례들이 보고된 바 있다. 이러한 보고들의 일환으로서, 저자들은 막성 루프스 신염이 같은 형제간에서 발병한 증례를 HLA 항원 검사결과와 함께 보고하는 바이다. The etiology of systemic lupus erythematosus (SLE) is thought to be multifactorial, and genetic factors may play some role in its pathogenesis. Supportive evidences of this hypothesis are the studies of identical twins and familial cases of SLE. As an another supporting piece of clinical evidence, we report on the cases of SLE in two brothers both of whom developed membranous lupus nephritis with the results of HLA profiles.
토끼 동방결절에서 완만내향전류의 Slow Component에 관한 연구
엄융의(Earm, Yung-E),김기환(Kim, Ki-Whan),황상익(Hwang, Sang-Ik) 대한생리학회 1984 대한생리학회지 Vol.18 No.1
The second inward current (i<sub>si</sub>) was studied by the two microelectrode voltage clamp technique in the sino-atrial node of the rabbit. The slow component (i<sub>si,2</sub>) of the second inward current was sometimes identified and i<sub>si</sub> behaved as if it were a mixture of two currents. We analysed the (i<sub>si,2</sub>) in relation to membrane potential and frequency of voltage clamp pulses. 1) Membrane was held at -40mV which was usually found to be zero current level. When depolarizing pulses were applied, the slow inward current i<sub>si</sub> was activated. 2) It was shown that there are three categories of the i<sub>si</sub> activation by the low level of depolarizing clamp pulses. Moderately fast inward current with single component was developed in most cases in the presence of tetrodotoxin(TTX). But sometimes there was two separate components of i<sub>si</sub> activation in the peak level and the time course. Thirdly the only slow component of i<sub>si</sub> was found in rare cases. 3) The activation of (i<sub>si,2</sub>) was dependent upon membrane potential. The i<sub>si</sub> shows two separate peaks during clamp depolarizations and higher clamp pulses lead to fusion of the peaks. 4) The i<sub>si,2</sub> activation showed that it decreased with repetitive clamp pulses and it was more evident in higher frequencies(2Hz)(negative staircase).
엄재호,이동호,조명찬,윤세진,궁성수,김승택,이복희 충북대학교 의과대학 충북대학교 의학연구소 1992 忠北醫大學術誌 Vol.2 No.1
Addison병은 점진적인 부신피질의 파괴에 의하여 나타나는 만성 부신피질 기능저하증으로 주로 자기면역기전에 의할 것으로 추정되는 특발성 부신피질 기능저하증과 결핵에 의해 발병되며, 빈도는 적으나 출혈성 경색, 전이암, 유육종증, 진균증 등에 의해서도 발병될 수 있다. 주요 증상은 전신쇠약, 색소과다침착, 체중감소, 오심, 구토 등이며 혈청 전해질 검사에서 저나트륨 혈증 및 고칼륨혈증이 관찰될 수 있다. 저자들은 심정지로 내원한 32세 남자환자에서 전신쇠약, 색소과다침착, 백반 등의 소견과 일반적인 치료에 반응하지 않는 고칼륨혈증에서 Addison병이 의심되어, 호르몬 검사를 한 결과, 혈장 부신피질 자극 호르몬 179.5 pg/mL, 코티솔 1.48 ㎍/mL로 Addison병을 확진하였으며, hydrocortisone 투여후에 고칼륨혈증과 전신쇠약이 호전된 예를 경험하였기에 보고하는 바이다. Addison's disease is a clinical syndrome which results from chronic, progressive destruction of adrenal cortex. The common causes are idiopathic atrophy and adrenal tuberculosis, and hemorrhagic infarct, metastatic carcinoma, sarcoidosis, chronic granulomatous diseas such as histoplasmosis, coccidioidomycosis and cryptococcosis can also cause primary adrenocortical insufficiency. Addison's disease is characterized by fatigability, weakness, hyperpigmentation, weight loss, nausea, vomiting and electrolyte imbalances including hyponatremia and hyperkalemia. We diagnosed Addison's disease in 32-year old male who showed severe weakness, hyperpigmentation and refractory hyperkalemia. The plasma ACTH and cortisol levels were 179.5 pg/mL and 1.48 ㎍/mL, respectively which showed primary adrenocortical insufficiency. The symptoms of hyperkalemia and weakness were markedly improved by intrevenous administration of hydrocortisone.
엄재호,한진석,이정상,김용일,김성권,이현순,김근호 대한신장학회 1989 Kidney Research and Clinical Practice Vol.8 No.3
This report described HLA identical sisters with IgA nephropathy, and it is the first case with HLA identical IgA nephropathy in Korea. The elder sister had frequent episodes of gross hematuria associated with upper respiratory tract infection, and younger sister had one episode of gross hematuria only. The renal biopsies revealed diffuse mesangial deposition of IgA, accompanied by lesser amount of C3 in immunofluorescent microscopy. Light and electron microscopic findings were compatible with IgA nephropathy. The HLA antigens were identical, which were All Aw24, B27 Bw35, Cwl Cw4, These findings are interesting in view of the association of IgA nephropathy with HLA-Bw35 antigen. Asike piror reports of HLA identical brothers with IgA nephropathy.
엄륭의,남기용,Earm, Yung-E,Nam, Kee-Yong 대한생리학회 1971 대한생리학회지 Vol.5 No.2
Thiocyanate space was determined in 23 bilaterally nephrectomized rabbits in acute metabolic acidosis and alkalosis. Acid-base disturbances were induced by the infusion of 0.3 N HCI or 0.3 N NaOH solution intravenously with the rate of 1 ml/min for 40 to 60 minutes. The blood pressure was monitored throughout the experiment and no changes in blood pressure was confirmed. The following results were obtained. 1. In the saline infused control rabbits, PH was 7.385 with negligible change in pH after the infusion, SCN space was 23.6% of body weight. 2. In the metabolic acidosis group, pH dropped from 7.417 to 7 130 and SCN space was 22.8% of body weight and suggested a negligible change in the extracellular space volume. 3. In the metabolic alkalosis group, pH increased from 7.393 to 7.478 and SCN space was 25.7% of body weight which confirmed a significant increase in the extracellular space volume.