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Phytochemical isoflavones against diabetic foot bacteria
Mazumdar, Kaushiki,Dutta, Noton Kumar,Dastidar, Sujata G.,Motohashi, Noboru,Shirataki, Yoshiaki Kyung Hee Oriental Medicine Research Center 2004 Oriental pharmacy and experimental medicine Vol.4 No.4
Wound swabs and pus samples were collected from diabetic foot ulcers, and control pus samples from non-diabetic cases. In 144 diabetic cases screened, Pseudomonas aeruginosa was isolated from 78 cases, in which 10.59% of the isolates were multidrug resistant (MDR), whereas the 60 control cases were not MDR. The isolated bacteria were decreasingly resistant to 6 clinically administrated antimicrobics such as ceftazidime, gentamicin, ciprofloxacin, tobramycin, piperacillin and amikacin. Therefore, it is demanded that new and more effective antimicrobials of phytochemical origins are sought after. Among 11 isoflavones (YS11-YS21) isolated from Sophora and Euchresta (Leguminosae; pea plant family), 2 (YS19 and YS21) prominently exhibited the high antibacterial activity both in vitro and in vivo. By the preliminary results, the object of this paper is to evaluate the in vitro antibacterial effect of YS19 and YS21 on the clinically isolated bactera of Ps. Aeruginosa in hospitals. All the isolates were sensitive to YS19 and YS21 and for both, minimum inhibitory concentration (MIC) values ranged from $2\;to\;50\;{\mu}g/mL$. The $MIC_{90}$ values of YS19 and YS21 were $50\;{\mu}g/mL$. It is suggested that these isoflavones might consist a basis phytochemical prevention and therapy for diabetic foot infections caused by pseudomonads.
Assessment of antibacterial activity of the cardiovascular drug nifedipine
Pal, Tapas,Dutta, Noton Kumar,Mazumdar, Kaushiki,Dasgupta, Asish,L., Jeyaseeli,Dastidar, Sujata G. Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.2
The cardiovascular drug nifedipine exhibited significant in vitro and in vivo antibacterial activity against 331 strains of bacteria belonging to three Gram-positive and twelve Gram-negative genera. The minimum inhibitory concentration of the drug, as determined both by agar and broth dilution methods, was seen to range from $25\;-\;200\;{\mu}g/ml$ against most test bacteria, including several pathogenic ones, in the in vitro studies. Nifedipine was bacteriostatic in action. in vivo studies with this drug showed that it could offer statistically significant protection (P < 0.001) to mice challenged with a virulent bacterium. Therefore, nifedipine has the potential of an antibacterial agent, which may be developed after further pharmacological studies.
Anti-Salmonella activity of a flavonone from Butea frondosa bark in mice
Uma Shankar Mishra,Noton Kumar Dutta,Kaushiki Mazumdar,Santosh Kumar Mahapatra,Pronobesh Chakraborty,Sujata G Dastidar 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.4
Butea frondosa has been used traditionally as a topical formulation in the treatment of many diseases and disorders. Two compounds [BF-1 (crystalline flavonol quercetin) and BF-2 (tannin) from ethyl acetate fraction of ethanolic extract] were isolated from the bark of Butea frondosa. The stereostructures of the compounds were determined on the basis of chemical and physicochemical evidence. BF-1 and BF-2 were screened in vitro for possible antibacterial property against 112 bacteria comprising 3 genera of Gram-positive and 12 genera of Gram-negative types. It was found that both BF-1 and BF-2 exhibited inhibitory activity against several bacteria. Most of these strains were inhibited by BF-1 at 50 - 200 μg/ml, while BF-2 (MIC50 400 μg/ml) was much less active. The bacteria could be arranged in the decreasing order of sensitivity towards BF-1 in the following manner: S. aureus, Bacillus spp., Salmonella spp., Vibrio spp., Shigella spp., E. coli and Pseudomonas spp. The MIC50 of the compound was 50 μg/ml while the MIC90 was 100 μg/ml. The decreasing order of sensitivity towards BF-2 was V. cholerae, Bacillus spp., S. aureus, V. parahaemolyticus, Salmonella spp. and Proteus spp. BF-1 was bactericidal in action. In vivo studies with this extract showed that it could offer statistically significant protection (p < 0.01) to mice challenged with a virulent bacterium. The inhibitory activity of Butea frondosa against Gram-positive and Gram-negative bacteria indicates its usefulness in the treatment of common bacterial infections. The potentiality of BF- 1 as an antibacterial agent may be confirmed further by pharmacological studies. Butea frondosa has been used traditionally as a topical formulation in the treatment of many diseases and disorders. Two compounds [BF-1 (crystalline flavonol quercetin) and BF-2 (tannin) from ethyl acetate fraction of ethanolic extract] were isolated from the bark of Butea frondosa. The stereostructures of the compounds were determined on the basis of chemical and physicochemical evidence. BF-1 and BF-2 were screened in vitro for possible antibacterial property against 112 bacteria comprising 3 genera of Gram-positive and 12 genera of Gram-negative types. It was found that both BF-1 and BF-2 exhibited inhibitory activity against several bacteria. Most of these strains were inhibited by BF-1 at 50 - 200 μg/ml, while BF-2 (MIC50 400 μg/ml) was much less active. The bacteria could be arranged in the decreasing order of sensitivity towards BF-1 in the following manner: S. aureus, Bacillus spp., Salmonella spp., Vibrio spp., Shigella spp., E. coli and Pseudomonas spp. The MIC50 of the compound was 50 μg/ml while the MIC90 was 100 μg/ml. The decreasing order of sensitivity towards BF-2 was V. cholerae, Bacillus spp., S. aureus, V. parahaemolyticus, Salmonella spp. and Proteus spp. BF-1 was bactericidal in action. In vivo studies with this extract showed that it could offer statistically significant protection (p < 0.01) to mice challenged with a virulent bacterium. The inhibitory activity of Butea frondosa against Gram-positive and Gram-negative bacteria indicates its usefulness in the treatment of common bacterial infections. The potentiality of BF- 1 as an antibacterial agent may be confirmed further by pharmacological studies.
Sung-Hoon Park,Noton Kumar Dutta,Min-Won Baek,김동재,나이랑,석승혁,Byoung-Hee Lee,Ji-Eun Cho,Geon-Sik Cho,Jae-Hak Park 대한수의학회 2009 Journal of Veterinary Science Vol.10 No.2
The effect of NaCl plus 3% chitosan on the systolic blood pressure of spontaneously hypertensive rats (SHR) were evaluated and compared with NaCl plus KCl (NaCl, 49.36% + KCl 49.36%) and chitosan or NaCl treatment alone. In SHR, administration of NaCl plus chitosan (44 mM Na/day) for two months significantly decreased the systolic blood pressure greater than of NaCl plus KCl and NaCl alone. NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na+ excretion and decreased blood urea nitrogen levels. Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups. Serum electrolytes levels, however, remained unchanged. The combination of NaCl and chitosan may be superior to the conventional use of NaCl plus KCl or NaCl alone in the prevention of hypertension. Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.
Anti-Salmonella activity of a flavonone from Butea frondosa bark in mice
Mishra, Uma Shankar,Dutta, Noton Kumar,Mazumdar, Kaushiki,Mahapatra, Santosh Kumar,Chakraborty, Pronobesh,Dastidar, Sujata G Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.4
Butea frondosa has been used traditionally as a topical formulation in the treatment of many diseases and disorders. Two compounds [BF-1 (crystalline flavonol quercetin) and BF-2 (tannin) from ethyl acetate fraction of ethanolic extract] were isolated from the bark of Butea frondosa. The stereostructures of the compounds were determined on the basis of chemical and physicochemical evidence. BF-1 and BF-2 were screened in vitro for possible antibacterial property against 112 bacteria comprising 3 genera of Gram-positive and 12 genera of Gram-negative types. It was found that both BF-1 and BF-2 exhibited inhibitory activity against several bacteria. Most of these strains were inhibited by BF-1 at $50-200\;{\mu}g/ml$, while BF-2 ($MIC_{50}$ $400\;{\mu}g/ml$) was much less active. The bacteria could be arranged in the decreasing order of sensitivity towards BF-1 in the following manner: S. aureus, Bacillus spp., Salmonella spp., Vibrio spp., Shigella spp., E. coli and Pseudomonas spp. The $MIC_{50}$ of the compound was $50\;{\mu}g/ml$ while the $MIC_{90}$ was $100\;{\mu}g/ml$. The decreasing order of sensitivity towards BF-2 was V. cholerae, Bacillus spp., S. aureus, V. parahaemolyticus, Salmonella spp. and Proteus spp. BF-1 was bactericidal in action. In vivo studies with this extract showed that it could offer statistically significant protection (p < 0.01) to mice challenged with a virulent bacterium. The inhibitory activity of Butea frondosa against Gram-positive and Gram-negative bacteria indicates its usefulness in the treatment of common bacterial infections. The potentiality of BF-1 as an antibacterial agent may be confirmed further by pharmacological studies.
Enzyme-Linked Immunosorbent Assay to Detect the MHV Infection in Mice
Yi-Rang Na,Seung-Hyeok Seok,Min-Won Baek,Hui-Young Lee,Dong-Jae Kim,Kyoung-Jin Noh,Sung-Hoon Park,Hyun-Kyoung Lee,Noton Kumar Dutta,Byoung-Hee Lee,Jae-Hak Park 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.4
Mouse hepatitis virus (MHV) is one of the major troublesome infectious diseases in laboratory mice. ELISA techniques generally have been shown to be more sensitive than other diagnostic methods for detection of MHV infection. Here, we developed an ELISA test method by using MHV type-2 strain and it gave reliable test results about detection of MHV infection in mice with high accuracy and low costs.
Down-regulation of RUNX3 induced by Helicobacter pylori in mouse splenocyte
( Min Won Baek ),( Seung Hyeok Seok ),( Hui Young Lee ),( Dong Jae Kim ),( Yi Rang Na ),( Sung Hun Park ),( Hyun Kyoung Lee ),( Dutta Noton Kumar ),( Byoung Hee Lee ),( Jae Hak Park ) 한국동물실험대체법학회 2007 한국동물실험대체법학회 학술대회집 Vol.2007 No.1
RUNX3 is necessary for the suppression of cell proliferation and apoptosis of the gastric epithelium, quantitative neurogenesis of the dorsal root ganglia, and differentiation of T & B-cell. Because of its tumor suppressor ability, RUNX3 is the target gene of cancer diagnosis and therapeutic approach. Helicobacter pylori is well known carcinogen for gastric cancer and MALT lymphoma Therefore, the direct induction of RUNX3 decrease by H. pylori was investigated here using mouse splenocyte. During 2 days of incubation with bacterial lysate a dose-dependent and time-dependant decrease of RUNX3 mRNA and protein was found, which was followed by RUNX3 P2 promoter region hypermethylation detected by methylation specific PCR and was not observed after treatment with Escherichia coli lysate (control). This decrease of RUNX3 mRNA and protein may be a link between H. pylori infection and development of gastric adenocarcinoma and MALT lymphoma.