http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Cho, Eugene,Lee, Jin-Kyung,Lee, Jee-Young,Chen, Zhihao,Ahn, Sun-Hee,Kim, Nam Doo,Kook, Min-Suk,Min, Sang Hyun,Park, Byung-Ju,Lee, Tae-Hoon MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.11
<P>Osteoporosis is caused by an imbalance of osteoclast and osteoblast activities and it is characterized by enhanced osteoclast formation and function. Peptidyl-prolyl cis-trans isomerase never in mitosis A (NIMA)-interacting 1 (Pin1) is a key mediator of osteoclast cell-cell fusion via suppression of the dendritic cell-specific transmembrane protein (DC-STAMP). We found that <I>N</I>,<I>N</I>′-1,4-butanediylbis[3-(2-chlorophenyl)acrylamide] (BCPA) inhibited receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastogenesis in a dose-dependent manner without cytotoxicity. In addition, BCPA attenuated the reduction of Pin1 protein during osteoclast differentiation without changing <I>Pin1</I> mRNA levels. BCPA repressed the expression of osteoclast-related genes, such as <I>DC-STAMP</I> and osteoclast-associated receptor (<I>OSCAR</I>), without altering the mRNA expression of nuclear factor of activated T cells (<I>NFATc1</I>) and cellular oncogene fos (<I>c-Fos</I>). Furthermore, Tartrate-resistant acid phosphatase (TRAP)-positive mononuclear cells were significantly decreased by BCPA treatment compared to treatment with the Pin1 inhibitor juglone. These data suggest that BCPA can inhibit osteoclastogenesis by regulating the expression of the DC-STAMP osteoclast fusion protein by attenuating Pin1 reduction. Therefore, BCPA may be used to treat osteoporosis.</P>