http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Li Dongwei,Park So Eun,Lee Mi Rong,Kim Jong Cheol,Lee Se Jin,김재수 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.3
The melon thrip, Thrips palmi Karny, is a worldwide pest that causes severe damage to a wide range of host plants. Current management mainly relies on sprayable synthetic chemicals that target adult, egg, and larval stages. However, these chemicals have adverse effects on the environment and induce resistance in thrips. An alternative environmentally sound management method with a different mode of action, targeting the soildwelling stage of thrips, was considered in this work. Bioassay of seven Beauveria bassiana isolates under lab oratory conditions revealed that two isolates, JEF-350 and JEF-341, were highly virulent against melon thrips. Conidial production and thermotolerance of JEF-341 and JEF-350 were compared with those of the commercial isolate B. bassiana ERL836 (Chongchaesak GR). B. bassiana JEF-350 showed similar conidial production to ERL836 but had significantly higher thermotolerance than JEF-341 and ERL836. Dose-dependent virulence of JEF-350 was tested in pot and field conditions, and JEF-350 millet-based fungal granules were applied to the soil surface to target the pupal stage of melon thrips. In the pot and field trials, JEF-350 granules significantly reduced thrip population with greater efficacy than JEF-341 and ERL836 granules. In application, JEF-350 needs to be carefully applied when in combination with chemical fungicides to ensure survival. Our results suggest that B. bassiana JEF-350 could be effectively used to control the pupal stage of melon thrips in soil.
Fungal library for developing biopesticides to control thrips
Dongwei Li,Sihyeon Kim,Jong Cheol Kim,So Eun Park,Mi Rong Lee,Sehyeon Baek,Tae Young Shin,Jae Su Kim 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
Thrips is one of the serious insect pests in many economic crops, in which general managements rely mainly on chemical insecticides. However, the overuse of chemicals led to the development of insect resistance and environmental residual issues. Therefore, thrips management requires the consideration of alternative strategies which are less harmful to the environment and working on different target points. In this work, we isolated entomopathogenic fungi from soil, and identified them with morphological and molecular biology methods, followed by a preliminary virulence assay against Tenebrio molitor larvae. Selected fungal isolates were adjusted to 1×107 conidia/ml for an indoor virulence assay against thrips adults, and highly virulent isolates were added to a thrip-pathogenic fungal library. Biological characteristics of efficacious isolates were investigated comparing to a previously commercialized fungal isolate. This entomopathogenic fungal library could be used as a valuable resource for developing effective strains to control thrips in agricultural fields.
Building of entomopathogenic fungal library to manage melon thrips, Thrips palmi Karny
Dongwei Li,Sihyeon Kim,Se Jin Lee,Mi Rong Lee,Jong Cheol Kim,So Eun Park,Tae Young Shin,Jae Su Kim 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.04
Melon thrips, Thrips palmi Karny (Thysanoptera: Thripidae) is a worldwide polyphagous pest. The management of this pest have mainly relied on chemical agents. However, the overuse is harmful to the environment and results in insects resistance. Therefore, alternative eco-friendly control methods that have different mode of action, such as biological control, are necessary to overcome the current issue. In this study, we isolated entomopathogenic fungi from Korean soil, and characterized them via morphological and molecular techniques and pathogenicity assay against Tenebrio molitor larvae. The isolated fungi were screened for virulence against T. palmi under laboratory conditions and the results were used to establish a thrips-pathogenic fungal library. The highly virulent isolates were selected and further characterized for optimum culture conditions and application as biopesticide in the field.
Construction of an entomopathogenic fungal library for controlling Thrips palmi Karny
Dongwei Li,Sihyeon Kim,Se Jin Lee,Mi Rong Lee,Jong Cheol Kim,So Eun Park,Tae Young Shin,Jae Su Kim 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.04
Melon thrips, Thrips palmi Karny (Thysanoptera: Thripidae) is a serious insect pest of various crops in the world. The management of this pest mainly have relied on chemical agents. However, the overuse of chemical agents for long times causes insect resistance, and negative effects on environment. Therefore, alternative control methods, such as biological control, that are less harmful to the environment and have different mode of action are needed to control this pest. In this study, we isolated entomopathogenic fungi from Korean soil, and characterized them via morphological and molecular identifications and pathogenicity check against Tenebrio molitor larvae. The isolated fungi were subjected to virulence assay against T. Palmi with a conidial suspension of 1×107 conidia/ml in laboratory conditions. This entomopathogenic fungi library would be a good resource to select effective strains for the control of T. palmi in fields.
Li Guoguang,Sheng Liang,Duan Baojun,Li Yang,Hei Dongwei,Xing Qingzi 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.7
In this paper, we use a Monte Carlo (MC) simulation based on Geant4 to investigate the influence of four parameters on the spatial resolution of the lens-coupled lutetium yttrium orthosilicate (LYSO) scintillator, including the thickness of the LYSO scintillator, the F-number and minification factor of the lens, and the incident position of the gamma-rays. Simulation results show that when the gamma-rays are incident along the lens axis, the smaller the thickness, the larger the F-number, the larger the minification factor, the higher the spatial resolution, with an isotropic point spread function (PSF). As the incident position of the gamma-rays deviates from the lens axis, the spatial resolution decreases, and the PSF becomes anisotropic. In addition, by analyzing the whole physical process of the lens-coupled LYSO scintillator from gamma-rays to secondary electrons to fluorescence photons, we aim to provide a detailed analysis of the influence of each parameter on the spatial resolution. The results show that the PSF of the secondary electrons energy deposition is almost constant in the simulation, which determines the upper limit of the spatial resolution. Meanwhile, the dispersion process of the fluorescence photons can explain the reason why each parameter affects the spatial resolution.
Dongwei Yuan,Li Qing,Lu Xing,Lan Jianfeng,Qiu Zhidong,Wang Xuehong,Wang Junnan,Zheng Xiaojiao,Chen Sifan,Zhang Chong,Jin Junfei 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Acute liver injury is the basis of the pathogenesis of diverse liver diseases. However, the mechanism underlying liver injury is complex and not completely understood. In our study, we revealed that CERK, which phosphorylates ceramide to produce ceramide-1-phosphate (C1P), was the sphingolipid pathway-related protein that had the most significantly upregulated expression during acute liver injury. A functional study confirmed that CERK and C1P attenuate hepatic injury both in vitro and in vivo through antioxidant effects. Mechanistic studies have shown that CERK and C1P positively regulate the protein expression of NRF2, which is a crucial protein that helps maintain redox homeostasis. Furthermore, our results indicated that C1P disrupted the interaction between NRF2 and KEAP1 by competitively binding to KEAP1, which allowed for the nuclear translocation of NRF2. In addition, pull-down assays and molecular docking analyses revealed that C1P binds to the DGR domain of KEAP1, which allows it to maintain its interaction with NRF2. Importantly, these findings were verified in human primary hepatocytes and a mouse model of hepatic ischemia‒reperfusion injury. Taken together, our findings demonstrated that CERK-mediated C1P metabolism attenuates acute liver injury via the binding of C1P to the DGR domain of KEAP1 and subsequently the release and nuclear translocation of NRF2, which activates the transcription of cytoprotective and antioxidant genes. Our study suggested that the upregulation of CERK and C1P expression may serve as a potential antioxidant strategy to alleviate acute liver injury.
The Foxo1-YAP-Notch1 axis reprograms STING-mediated innate immunity in NASH progression
Xu Dongwei,Qu Xiaoye,Yang Tao,Sheng Mingwei,Bian Xiyun,Zhan Yongqiang,Tian Yizhu,Lin Yuanbang,Jin Yuting,Wang Xiao,Ke Michael,Jiang Longfeng,Li Changyong,Xia Qiang,Farmer Douglas G.,Ke Bibo 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Innate immune activation is critical for initiating hepatic inflammation during nonalcoholic steatohepatitis (NASH) progression. However, the mechanisms by which immunoregulatory molecules recognize lipogenic, fibrotic, and inflammatory signals remain unclear. Here, we show that high-fat diet (HFD)-induced oxidative stress activates Foxo1, YAP, and Notch1 signaling in hepatic macrophages. Macrophage Foxo1 deficiency (Foxo1M-KO) ameliorated hepatic inflammation, steatosis, and fibrosis, with reduced STING, TBK1, and NF-κB activation in HFD-challenged livers. However, Foxo1 and YAP double knockout (Foxo1/YAPM-DKO) or Foxo1 and Notch1 double knockout (Foxo1/Notch1M-DKO) promoted STING function and exacerbated HFD-induced liver injury. Interestingly, Foxo1M-KO strongly reduced TGF-β1 release from palmitic acid (PA)- and oleic acid (OA)-stimulated Kupffer cells and decreased Col1α1, CCL2, and Timp1 expression but increased MMP1 expression in primary hepatic stellate cells (HSCs) after coculture with Kupffer cells. Notably, PA and OA challenge in Kupffer cells augmented LIMD1 and LATS1 colocalization and interaction, which induced YAP nuclear translocation. Foxo1M-KO activated PGC-1α and increased nuclear YAP activity, modulating mitochondrial biogenesis. Using chromatin immunoprecipitation (ChIP) coupled with massively parallel sequencing (ChIP-Seq) and in situ RNA hybridization, we found that NICD colocalizes with YAP and targets Mb21d1 (cGAS), while YAP functions as a novel coactivator of the NICD, which is crucial for reprogramming STING function in NASH progression. These findings highlight the importance of the macrophage Foxo1–YAP–Notch1 axis as a key molecular regulator that controls lipid metabolism, inflammation, and innate immunity in NASH.