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Lee, Hyungsoo,Choi, Jin Hyeok,Jo, Min Chul,Lee, Donghyun,Shin, Sangmin,Jo, Ilguk,Lee, Sang-Kwan,Lee, Sunghak Elsevier 2018 Materials science & engineering. properties, micro Vol.738 No.-
<P><B>Abstract</B></P> <P>Quasi-static and dynamic compressive properties of 7075-T6 Al matrix composites reinforced with SiC<SUB>p</SUB>s (size; 10 µm, 30 µm, and bimodal (10 + 30) μm), <I>i.e</I>., 10S, 30S, and BS composites, respectively, were investigated in relation with fracture mechanisms. SiC<SUB>p</SUB>s were homogeneously distributed without SiC<SUB>p</SUB> agglomeration, pores, or cracks, and their volume fractions were 49.5 vol%, 54.1 vol%, and 56.5 vol% in the 30S, 10S, and BS specimens, respectively. Compressive properties could be explained by a rule of mixtures based on SiC<SUB>p</SUB> volume fraction and by three major fracture phenomena including deformation of Al matrix, cracking of SiC<SUB>p</SUB>s, and interfacial debonding between SiC<SUB>p</SUB> and Al. As the SiC<SUB>p</SUB> size decreased, crack initiation sites changed from SiC<SUB>p</SUB>s themselves to SiC<SUB>p</SUB>/Al interfaces, which mainly affected the compressive strength. In the BS composite, coarse SiC<SUB>p</SUB>s additionally worked for the strengthening by increasing the total reinforcement fraction, and the three fracture phenomena were well homogenized, thereby leading to the highest strain energy density as well as the best combination of strength and strain.</P>
Lee, Yeonjae,Kang, Ryan,Kwon, Jenna,Jo, Kyuhee,Im, Jungbin,Jung, Sangwook,Lee, DongHyun,Lee, Juhyeon,Lee, Jeong-Sang The Institute of Internet 2018 International journal of advanced smart convergenc Vol.7 No.2
Celiac disease (CD) is an immune-mediated enteropathy of small intestine diagnosed in both childhood and adulthood. CD is caused by gluten, which produces gliadorphin during its digestion. The enzyme dipeptidyl peptidase-4 (DPP4) breaks gliadorphin down nevertheless the last tripeptide remains and eventually inhibits DPP4, thus slowing down its process. Therefore, the idea is to produce an additional DPP4 enzyme which is crucial. Consequently, the functional DPP4 gene was cloned into pCDNA3 intermediate (FLAG+DPP4) vector and finally a recombinant plasmid pSB1C3 (Andersons promoters+FLAG+DPP4) was constructed using synthetic biology. Normally, a DPP4 inhibitor is used as a cure for diabetes. Another important concern was overexpression of DPP4, which might lead to diabetes, accordingly the work was also performed for the regulation of the DPP4 gene expression. In this regard, three types of Anderson promoters (strong, moderate and weak) were utilized to study the control overexpression. This is the first report of idealistic trial for control the exogenous DPP4 gene-expression by molecular biologic tools.
AlGaN-based deep ultraviolet light-emitting diodes on nanopatterned AlN/sapphire substrates
Donghyun LEE,Jong Won LEE,Jeonghwan JANG,In-Su SHIN,Lu JIN,Jungsub KIM,Jinsub LEE,Hye-Seok NOH,Yong-Il KIM,Youngsoo PARK,Gun-Do LEE,Yongjo PARK,Jong Kyu KIM,Euijoon YOON 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8
Use of Baicalin-Conjugated Gold Nanoparticles for Apoptotic Induction of Breast Cancer Cells
Lee, Donghyun,Ko, Wan-Kyu,Hwang, Deok-Sang,Heo, Dong Nyoung,Lee, Sang Jin,Heo, Min,Lee, Kook-Sun,Ahn, Ji-Yoon,Jo, Junyoung,Kwon, Il Keun SPRINGER SCIENCE + BUSINESS MEDIA 2016 NANOSCALE RESEARCH LETTERS Vol.11 No.1
<P>Baicalin (BC) has been used for cancer therapy due to its multiple effects as an anti-cancer drug. However, the effective delivery of this molecule to targeted cells is difficult. Gold nanoparticles (AuNPs) conjugated with thiolated beta cyclodextrin (AuNP-S-β-CD) were used as a delivery vector in this study. Cell viability tests were evaluated by cell counting kit-8 (CCK) and live/dead cell assay. To demonstrate the proliferation inhibition effect on Michigan Cancer Foundation-7 (MCF-7) cells by BC, we analyzed using Hoechst 33342 staining assay and gel electrophoresis. The S-β-CD conjugated AuNPs were characterized by transmission electron microscopy (TEM), 1H nuclear magnetic resonance (<SUP>1</SUP>H NMR), and ultraviolet visible (UV-vis) spectroscopy. AuNP-S-β-CD with approximately 40 μM of BC loaded by inclusion complex showed an inhibition effect on MCF-7 cells by inducing apoptosis. Apoptosis test results were evaluated by analyzing the expression of typical apoptic markers such as cleaved caspase-3, full length caspase-3, and apaf-1 in western blot assay. These results demonstrated that AuNP-S-β-CD-BC inhibited the proliferation of cancerous MCF-7 cells by inducing apoptosis. These findings suggested that AuNP-S-β-CD-BC could be a promising agent for chemotherapeutic usage.</P>
Lee, Donghyun,Heo, Dong Nyoung,Nah, Ha Ram,Lee, Sang Jin,Ko, Wan-Kyu,Lee, Jae Seo,Moon, Ho-Jin,Bang, Jae Beum,Hwang, Yu-Shik,Reis, Rui L,Kwon, Il Keun Dove Medical Press 2018 International journal of nanomedicine Vol.13 No.-
<P><B>Background</B></P><P>For effective bone regeneration, it is necessary to implant a biocompatible scaffold that is capable of inducing cell growth and continuous osteogenic stimulation at the defected site. Here, we suggest an injectable hydrogel system using enzymatic cross-linkable gelatin (Gel) and functionalized gold nanoparticles (GNPs).</P><P><B>Methods</B></P><P>In this work, tyramine (Ty) was synthesized on the gelatin backbone (Gel-Ty) to enable a phenol crosslinking reaction with horseradish peroxidase (HRP). N-acetyl cysteine (NAC) was attached to the GNPs surface (G-NAC) for promoting osteodifferentiation.</P><P><B>Results</B></P><P>The Gel-Ty hydrogels containing G-NAC (Gel-Ty/G-NAC) had suitable mechanical strength and biocompatibility to embed and support the growth of human adipose derived stem cells (hASCs) during a proliferation test for three days. In addition, G-NAC promoted osteodifferentiation both when it was included in Gel-Ty and when it was used directly in hASCs. The osteogenic effects were demonstrated by the alkaline phosphatase (ALP) activity test.</P><P><B>Conclusion</B></P><P>These findings indicate that the phenol crosslinking reaction is suitable for injectable hydrogels for tissue regeneration and G-NAC stimulate bone regeneration. Based on our results, we suggest that Gel-Ty/G-NAC hydrogels can serve both as a biodegradable graft material for bone defect treatment and as a good template for tissue engineering applications such as drug delivery, cell delivery, and various tissue regeneration uses.</P>
Lee, Sukjun,Lim, Donghyun,Lee, Eunyoung,Lee, Nakyung,Lee, Hong-gun,Cechetto, Jonathan,Liuzzi, Michel,Freitas-Junior, Lucio H.,Song, Jin Sook,Bae, Myung Ae,Oh, Sangmi,Ayong, Lawrence,Park, Seung Bum American Chemical Society 2014 Journal of medicinal chemistry Vol.57 No.17
<P>New antimalarial agents that exhibit multistage activities against drug-resistant strains of malaria parasites represent good starting points for developing next-generation antimalarial therapies. To facilitate the progression of such agents into the development phase, we developed an image-based parasitological screening method for defining drug effects on different asexual life cycle stages of <I>Plasmodium falciparum</I>. High-throughput screening of a newly assembled diversity-oriented synthetic library using this approach led to the identification of carbohybrid-based 2-aminopyrimidine compounds with fast-acting growth inhibitory activities against three laboratory strains of multidrug-resistant <I>P. falciparum</I>. Our structure–activity relationship study led to the identification of two derivatives (<B>8aA</B> and <B>11aA</B>) as the most promising antimalarial candidates (mean EC<SUB>50</SUB> of 0.130 and 0.096 μM against all three <I>P. falciparum</I> strains, selectivity indices >600, microsomal stabilities >80%, and mouse malaria ED<SUB>50</SUB> values of 0.32 and 0.12 mg/kg/day, respectively), targeting all major blood stages of multidrug-resistant <I>P. falciparum</I> parasites.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2014/jmcmar.2014.57.issue-17/jm5009693/production/images/medium/jm-2014-009693_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm5009693'>ACS Electronic Supporting Info</A></P>
Donghyun Lee,Seungchan Cho,Junghwan Kim,Sang-bok Lee,Sang-kwan Lee 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.2
B4C/Al composite is mainly used for neutron absorbing materials, which is one of the components of equipment that manages spent nuclear fuel. There are various processes for manufacturing neutron absorbing materials, but most of them are based on the powder metallurgy. In this study, B4C/Al composite in which the reinforcement was uniformly dispersed was manufactured by using the stir casting process. The microstructure, thermal neutron absorption rate, mechanical properties and dispersibility of the reinforcement of the prepared B4C/Al composite were analyzed.