Baculovirus Vector System에 의해 발현된 재조합 Pseudorabies Virus Major Capsid Protein의 면역원성

전무형,안동준,장경수,조용성,박종현,송재영,현방훈,안수환 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

The recombinant pseudorabies virus major capsid protein (rMCP) was produced by expression of the MCP gene in Sf-9 cell using baculovirus transfer vector system. Following evaluation of the immunochemical properties of the rMCP, the immunogenicity of the recombinant subunit protiens were investigated in guinea pig and swine to obtain the preliminary guide line for the subunit vaccine using rMCP and gP50. It was proved that ultrasonication and 30% ammonium sulfate was most efficient to concentrate and purify the protein. The rMCP was safe in mice, guinea pigs and piglets. In guinea pigs, rMCP mixed with various adjuvants induced substantial degree of serum neutralizing antibody titers, but revealed incomplete protecivity against challenge. In swine, the combination of rMCP and gP50 showed the higher serum neutralizing antibody titers and cellular immune responses than rMCP alone. However, the protectivity was lower in comparison with the commercial gI-deleted inactivated vaccine. We expect these results to contribute to characterization of MCP gene of Korean isolate of PRV and to ultilize as preliminary information for prodution and evaluation of PRV recombinant subunit vaccines.

임의의 외부 정전하에 대한 SU(2)양밀즈방정식의 일반적 비가환해

전정환,김동주 中央大學校 基礎科學硏究所 1995 基礎科學硏究所 論文集 Vol.9 No.-

Non-Abelian solutions of SU(2) Yang-Mills equations for arbitrary external static sources are constructed starting with sources distributed over many concentric thin spherical shells, which include those for a point charge. It is found that there are many ways of constructing non-Abelian solutions for given sources. Also many ways of screening are discussed.

이온교환법에 의한 탈질소 공정개발의 기초연구 (Ⅴ) : 질산성 질소 선택적인 이온교환수지의 합성 Synthesis of Nitrate-Selective lon Exchange Resines

이동환,김승일,전진희,박찬영,이민규 한국환경과학회 2000 한국환경과학회지 Vol.9 No.4

Nitrate-selective ion exchange resin which have bulky tertiary amine as functional group have been synthesized by the reaction of chloromethylated polystyrene-divinylbenzene copolymer and the corresponding tertiary amine [NR_3=NEt_3 1, N(C_2H_4OH)_3 2] in ethanol, while commercial resin has NMe_3 as functional group. The fundamental properties such as bulk density, water content, appearance index, exchange capacity, effective size, uniformity coefficient of synthesized anion exchange resin (1) have been measured. The ion exchange resin (1) and (2) exhibited the better selectivity for nitrate than sulfate in both batch and continuous column experiments.

2000-2008년 수도권 지역의 가와사끼병의 역학적 연구

박형준,김영대,김우경,송영환,김동욱,박용원 인제대학교 2009 仁濟醫學 Vol.30 No.-

Objectives : The aim of this study was to investigate the clinical features and epidemiologic pattern of Kawasaki disease(KD) in Seoul metropolitan area for the 9-year-period. Methods : An epidemiologic survey on KD was retrospectively performed. The questionnaire was sent to 3 hospitals including Seoul Paik hospital, Sanggye Paik hospital and Ilsan Paik hospital, and obtained data were analyzed. Results : Data from a total of 1,297 cases were collected. The male-to-female ratio was 1.33:1(741:556), and the mean age of onset was 32.2 months. The monthly number of patients was slightly higher in May, June and December. There was no sibling case and rate of recurrence cases was 2.31%(30/1,297), and the proportion of patients with KD among total hospitalized pediatric patients was 2.05%. Coronary arterialu..A) abnormalities were detected at follow-up by echocardiogram in 17.2%(204/1,185) of cases including 0.76% of aneurysms. Conclusion : Comparing with the data of the KD patients in Korea(1.48%), our data of 1,297 KD patients area showed higher proportion of patients with KD among total hospitalized pediatric patient(2.05%).

단백뇨를 보이는 사구체 질환 및 당뇨병성 신병증에서의 Lp(a)

권태환,김준홍,조성,김석재,김용림,조동규,백미영 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

Background: Recently there has been evidences that serum Lp(a), an independent risk factor to atherosclerotic cardiovascular diseases, were increased in proteinuric disorders such as nephrotic syndrome and diabetic nephropathy. Methods: We intended to search of altered concentrations of Lp(a) in proteinuric disorder measuring serum Lp(a) concentrations with ELISA in 44 glomerulonephritic patients(25 nephrotic syndrome(NS), 19 non-nephrotic range proteinuric glomerulonephritis(GN), 25 diabetic nephropathy patients(DN), and 31 healthy controls(HC). Also, we compared Lp(a) concentration between glomerulonephritis patients and diabetic nephropathy patients with proteinuria of similar degree. Results: 1) There were significantly increased levels of total choesterol, triglyceride, and LDL-cholesterol in Ns compared to GN, DN, HC. 2) There were significantly increased concentrations of serum Lp(a) in NS compared to HC, but no signiicant difference in serum Lp(a) among NS, GN, and DN. 3) There was no significant difference in serum Lp(a) concentrations between NS & DN with 24 hour urine protein greater than 3.0g. 4) There was no significant difference in serum Lp(a) concentration between GN with 24 hour urine protein greater than 0.5g and less than 1.5g and DN with proteinuria of simial degree. 5) In glomerulonephritis patients, there was negative correlation between serum Lp(a) concentration and serum albumin level but correlation with 24 hour urinary protein, total cholesterol, Ldl-cholesterol, and HDL-cholesterol was not shown. In diabetic nephropathy, there was no significant correlation among serum Lp(a) concentration and all parameters including serum albumin, 24 hour urinary protein, and other lipid profiles. Conclusion: The present study confirmed that patients with nephrotic syndrome of diverse etiologies have makedly increased plasma level of Lp(a), in conjunction with other lipid abnormalities. However, this study shows no difference in Lp(a) concentrations between diabetic nephropathy and glomerulonephritis with similar degree of proteinuria.

이동 로봇의 자율 주행제어

석진환,오세봉,Nguyen Van-Quyet,한성현,박동준 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

This paper achieves a research about remote control of robot based on voice recognition. Through real-time remote control and wireless network capabilities of an unmanned remote-control experiments and Home Security / exercise with an unmanned robot, remote control and voice recognition and voice transmission are possible to transmit on a PC using a microphone to control a robot to pinpoint of the source. Speech recognition can be controlled robot by using a remote control. In this research, speech recognition speed and direction of self-driving robot were controlled by a wireless remote control in order to verify the performance of mobile robot controller.

방전관용 전극개발 및 특성에 관한 연구

안성환,황동원,최준영,송시준,전용우,박원주,이광식 영남대학교 공업기술연구소 2001 工業技術硏究所論文集 Vol.29 No.1

This paper describes the development of sputtered tungsten electrode for discharge tube by making use of Sputtering method using plasma. The Xe discharge tube was designed and fabricated by using sputtered tungsten electrode, and the ICCD(Intensified Charged Coupled Device) and monochromator were used in order to observe the discharge image distribution and to measure the signal intensity. As a result, the emission light form the electrode was spreaded almost uniformly over a wide wavelength band, and the discharge image distribution and the signal intensity show quite a uniform distribution. The emission light from the Xe discharge tube was peaked at 488[nm] and 648[nm].

상완골 근위부 골절 치료에서 잠김 압박 금속판의 유용성

김동휘,이준영,조승환,양훈,하상호 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.34 No.1

Purpose: To prove the efficacy of locking compression plate (LCP) in proximal humerus fracture. Materials and Methods: Forty four out of 48 patients who had proximal humerus fracture operation with LCP from November, 2004 to June, 2008 and available for follow up for more than 6 months were evaluated. Eighteen cases were male and 26 cases were female with mean age of 56 years (range 29-85 years). Cause of injury was traffic accident in 17 cases, slip down in 20 cases and fall down in 7 cases. Mean interval from injury to operation was 6.8 days (range 2-30 days) and mean operation time was 80. 5 minutes(range 40-130 minutes). Open reduction and internal fixation with LCP using deltopectoral approach was used in all cases. Postoperative clinical evaluation was done using Constant-Murley assessment and bone union and neck-shaft angle was checked using radiographic exam. Results: Bone union was achieved in 41 out of 44 cases at mean interval of 11.2 weeks(range 6-16 weeks). Mean neck-shaft angle was 129.7 degree (range 101-146) with more than 20 degree of angular deformation in 2 cases. For the complication, 2 cases of temporary axillary nerve injury, 1 case of nonunion, 2 case of delayed unions with angulation, 2 case of ankylosis was observed. Conclusion: LCP can prevent reduction loss and minimize soft tissue injury which result in firm fixation and early immobilization. It seem to be very efficient in treating proximal humerus fracture in elderly.

주요우울증에서 우울과 불안 증상의 심각도에 따른 뇌파 A1,A2, Percent 비대칭 지표들의 특성 연구

이준석,양병환,오동열,김기성 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.2

Objectives : In this study we investigated characteristics of asymmetry pattern of EEG in patients with major depressive disor-der according to the severity of depression and anxiety symptoms, employing A1, A2, and Percent (PCT) asymmetry indices. Methods : Subjects involved in this study were 11 healthy controls and 11 patients with major depressive disorder who have taken no medicines for four weeks just before the study. These subjects were selected so that the two groups can have no difference in gender and age. Beck Depression Inventory (BDI), 17-item Hamilton Depression Rating Scale (HDRS), Zung's Self-Rating Depression Scale (SDS) and Spielberger's State-Trait Anxiety Inventory (STAI) were used to evaluate depression and anxiety symptoms, respectively. Resting EEG was recorded &om F3, F4, C3, C4, T7, T8, 01 and 02 electrode sites. Results : The temporal region showed a difference in A1, A2, and PCT asymmetry indices between the depression group and the control group. Frontal (F3, F4) and temporal (T7, T8) regions showed correlation between STAI-T score and A1, A2, and PCT asymmetry indices. Conclusion : The results of this study showed that EEG A1, A2, and PCT asymmetry indices can be used as useful indices for depression. Also, it was found that trait anxiety had influence on A1, A2, and PCT asymmetry indices.

자기평가체형에 따른 사회적 체형불안과 신체적 자기개념

최영준,이동환,오갑진 한국스포츠심리학회 2003 한국스포츠심리학회지 Vol.14 No.4

본 연구는 자기평가체형이 사회적 체형불안과 신체적 자기개념에 어떠한 영향을 미치는지 분석하는데 그 목적이 있다. 구체적인 방법으로는 남·여 중학생 332명(남: 173명, 여:159명)을 대상으로 자신의 체형을 너무마름, 약간마름, 보통, 약간살찜, 너무살찜으로 평가한 집단간 사회적 체형불만(Social Physique Anxiety Scale, SPAS)과의 관계를 이원 단일변량분산분석(two way ANOVA)을 통해 알아보았고, 신체적 자기개념(Physical Self-Description Questionnaire, PSDQ)의 하위요인간의 관계를 알아보기 위해 이원 다변량분산분석(two way MANOVA)을 통해 알아보았다. 그리고 사회적 체형불안과 신체적 자기개념의 하위요인간의 상관관계를 알아보았다. 비교결과, 사회적 체형불안은 성별에 있어서는 유의한 차이가 나타나지 않았으나, 자기체형 인식에 따라서는 보통이라고 평가한 집단이 가장 낮고, 너무 살찜이라고 평가한 집단이 가장 높게 나타났다. 신체적 자기개념에서는 남학생이 신체활동, 건강, 지구력, 스포츠유능감 요인에서 여학생보다 높게 나타났고, 자기체형 인식에 따른 집단간에는 보통과 약간 마름의로 평가한 집단에서 체지방, 외모, 건강, 자기존중, 유연성, 지구력, 신체전반의 7개 요인에서 가장 높은 점수를 나타내었다. 마지막으로, 남학생과 여학생 모두 체지방과 자기존중에서 사회적 체형불안과 높은 상관관계가 발견되었고, 여학생에게서 더 높은 상관관계가 나타났다. 이외에도 여학생은 스포츠유능감요인과 지구력요인에서도 사회적 체형불안과 유의한 관계가 있다는 것이 발견되었다. 결론적으로, 자기체형을 어떻게 인식하고 있느냐에 따라 신체적 자기개념의 각 하위 구성요인에 차이가 난다는 것을 보여주고 있고, 사회적 체형불안과 신체적 자기개념과의 상관관계를 설명하는데 있어서 남학생보다는 여학생에게서 더 높은 관계를 나타내고 있다는 것을 시사하고 있다. The purpose of this study was to investigate the Social Physique Anxiety scale(SPAS) and the Physical Self-Description Questionnaire(PSDQ) among Lean Group, Slim Group, Normal Group, Fattish Group, and Fatty Group of 332 middle school students by the Korean Versions of the SPAS and the PSDQ. The results are as follows; On the Social Physique Anxiety, there was a significant difference with the main effect of Group(p< .05). Normal Group was lower than any other group and Fatty Group was higher than all the other groups. There was not a significant difference with the main effect of Gender. On the Physical Self-Description. boys were higher than girls in the scores of self-perceptions of physical activity, health, endurance, and sports competence. And Lean and Normal Groups were higher than the other Groups in the scores of self-perceptions of body fat, attractiveness, health, self esteem, flexibility, endurance, and global physical. Finally, body fat and self esteem showed high negative correlation coefficients with social physique anxiety for both boys and girls.