급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

금속가공유 사용 근로자에서 발생한 과민성폐장염 1예

이선웅,고동희,진구원,박동욱,이정탁,송윤희,이상윤 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.1

서론: 과민성폐장염의 원인물질로 금속가공유는 외국의 경우 작업장의 집단발병 사례들을 중심으로 많은 보고가 되어 왔으나 우리나라에서는 아직 보고되지 않았으며,저 자들은 금속가공유에 1년간 노출된 근로자에서 발생한 과민성폐장염 1예를 발견하였기에 작업환경측정을 시행한 후 작업관련성을 평가하여 보고하는 바이다. 증례: 64세 남자 환자가 1년간 강관을 절단하는 작업을 한 후 호흡곤란을 주소로 내원하였다 노출력,임상적 소견 및 방사선학적 소견을 토대로 과민성폐장염으로 진단되었다. 작업환경 측정결과 공기 중 금속가공유,엔도 톡신,총 세균 및 곰팡이는 각각 0.531 mg/m³, 6.33 EU/m³ 100 CFU/m³ 및 75 CFU/m³이었고,금속가 공유 내 엔도톡신,총세균 및 곰팡이는 각각 1.5x10⁴EU/mL,4.6x10^(5) CFU/mL 및 1.8×10^(5) CFU/mL이었다. 고찰: 금속가공유 내의 원인항원에 대한 침강항체를 검사하지 못했으나,작업환경 측정결과 금속가공유가 일반적인 허용가능 수준 이상으로 오염되었으며,기존의 과민성폐장염 발생 사례들과 비슷한 수준 또는 그 이상으로 오염되어 있었다. 공기 중 금속가공유 농도 역사 NIOSH의 REL과 ACGIH의 NIC를 초과하고,기존의 사례들에 비해서도 대체적으로 높은 수준 이었다. 금속가공유 이외의 다른 원인에 대한 감별과 기존의 발생사례들과의 노출수준 비교를 통하여,저자들은 환자가 금속가공유에 의한 미생물 항원에 노출되어 과민성폐장염이 발생한 것으로 판단하였다. Introduction: There have been no reports of hypersensitivity pneumonitis caused by metal working fluids in Korea, despite their existence in other countries. Here, we report the first such case, along with an assessment of work-relatedness through exposure assessment. Case report: A 64-year old male patient visited the hospital with dyspnea after metal pipe cutting for about a year. He was diagnosed with hypersensitivity pneumonitis from the evidence of specific exposure history, clinical symptoms, and radiologic findings. The air exposure levels of the oil mist, endotoxin, total bacteria and fungus in the work environment was TWA(8-hr) 0.531 mg/m³, 6.33 EU/m³, 100 CFU/m₃ and 75 CFU/m³, respectively. The concentrations of the endotoxin, total bacteria and fungus within the metal working fluid was 1.5 X 10⁴EU/mL, 4.6 X 10^(5) CFU/mL and 1.8 X 10^(5) CFU/mL, respectively. Discussion: Although the patient did not receive a specific precipitating antibody test, the microbial concentration within the metal working fluid was higher than normal and similar to previous case reports, The oil mist level in the air exceeded the NIOSH REL and ACGIH NIC, and were similar or higher than previous cases. By excluding other causes of hypersensitivity pneumonitis, we concluded that the disease developed from exposure to microbial antigens in the metal working fluid.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

有機農業의 實態와 發展에 관한 事例 硏究 : 忠南 洪城郡 洪東面 有機農家를 中心으로

尹英相,洪性贊,金成敏,具漢謨,申東一,金昌護,姜熙慶 公州大學校 資源科學硏究所 1997 資源科學硏究論文集 Vol.5 No.-

This study was carried out to improve the organic farming system about crop cultivation, compost production and application, plant diseases & pest control, weed control and marketing system of organic farming products to the case study in Chungnam Hongdong area. Agricultural technologies concerning pest & diseases control, weed control and compost production are not established due to lacks of systemized researches by the agricultural scientist, and agricultural machines profitable to this works had not developed yet. In cropping system, reasonable crop rotation had not conducted. The related cultivation of vegetables on the same ground for a long time cause a various plant disease easily. So crop rotation is a reasonable method about soil nutrient utility and soil disease control. It is a good method that introduce the barley and wheat in this field crop system. Those crop have a long root, so can use the other nutrient against the vegetable. In organic farming products, the safety and quality of products by the National Agricultural Products Inspection Center had not inspected except rice, lettus and apple. Inspection is needed for the development of organic farming and mutual confidence between producer and consumer, because the mutual confidence is a major thing to sustain the organic farming. In products marketing, it is more need for the information of organic farming products. Nowaday most products are marketed in Seoul region, but it is not a good method. To search the consumer in near region is a good method for decrease the cost of conveyance and maintain the quality of products. The varieties of distribution structure of organic farming products are required. The products are sold to department store in large city and the prices are about 30% higher than normal products. But when those are supplied in near region, the prices of those are similar to normal products. Direct transactions in near regions is a good method for decrease the cost of conveyance and strength the mutual confidence between producer and consumer.

성장과 운동수행능력 향상에 도움을 주는 식이조성물의 개발

윤승원,정은희,양동식,이홍석,윤유식 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.3

We developed a dietary supplement using natural herbs and nutrients for the growth and exercise performance improvement. It called JR-22 supplement containing distilled extracts of natural herbs to remove bitterness and the addition of Vitamin B1, B6, Ca and xylitol. We investigated on the effect of JR-22 supplementation on the maximal exercise performance, IGF-1 (insulin like growth factor-1) concentration and antioxidant activity in SD rat model. In result, JR-22 supplement group was better than control group about 10% in exercise performance test and increased about 63% of IGF-1 concentration in blood. In addition, the oxidative damage induced by exercise was reduced by JR- 22 supplementation. Therefore, we suggested that JR-22 supplementation enhanced effectively exercise performance and IGF-1 concentration and reduced to oxidative stress in muscles. Also, we analysed biochemical factors in blood for the safety of JR-22 supplement. We known that there is no change of blood lactic acid, ammonia, inorganic phosphorous ion and creatine kinase activity.

국적 항공사의 경쟁력 강화를 위한 포지셔닝 전략에 관한 연구

윤병국,이동희 한국관광정보학회 2001 觀光情報硏究 Vol.- No.9

The international airline industry has a phenomenal growth since the Airline Deregulation Act was enacted in 1978. In recent years, Korea's national flag carriers are facing steep challenges to survive in the ever-growing competition. Under the situation, positioning can be used as a competitive strategy tool. The purpose of the study was to analyze the image of seven airlines that fly to Korea and to develop positioning strategies for Korea's national flag carriers. For the empirical research, the survey data were collected from 700 passengers: 600 passengers who were on board Korean Air and Asiana Airlines and 100 from people who have flown seven major airlines: Korean Air, Asiana Airlines, Japan Airline, United Airline, Cathay Pacific Airways, Thai Airways, Singapore Airlines. Out of 700 samples, 377 were used for statistical analysis. Results of this study are summarized as follows: First, safety was the most significant attribute which influences on airlines image and airlines decision-making. On-time operation was the second most important attribute, but passengers were very unsatisfied with the actual performance. passengers who had the membership with airlines considered importantly the 'system-related service' factores such as frequent flyer program, mileage service, efficient reservation system and quick check-in procedure. Second, according to the results of comparative analysis of airlines, passengers assessed that the Korean Air has a strong image in convenient schedule and frequent flyer program. For the Asiana Airlines, passengers evaluated that the airline's image was found on quality of cabin service, safety, quality in-flight meal, low fares, and on-time operation. For the foreign airlines, passengers expressed that each airline has distinctive image. Future research on airline positioning strategies need to enlarge to more famous airlines. Thus, it is expected to help to set up competitive strategies for Korea's national flag carrier.

국내산 중하(Metapenaeus joyneri) 내 주알레르겐 규명 : 가열 및 소화액에 의한 변화

윤성호,김현아,김현미,최정희,서창희,남동호,김윤근,민경업,박해심 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

제자리 점프헤딩의 운동학적 연구

윤희중,문동안,이연종 한국운동역학회 1997 한국운동역학회지 Vol.7 No.1

The purpose of present study was to clarify the kinematics characteristics of standing-jump-heading by means of three-dimensional analysis of cinematography. Twenty male students were participated in the experiment as subjects. They consisted of 10 soccer players as a skilled group, and 10 control students which did never participated in the soccer club as an unskilled group. Each subject was instructed to jump by two legs for the ball which suspended with ball-pendurum. The movements of standing-jump-heading were filmed with 16mm high speed cameras that set at perpendicular position. From the obtained results, the characteriatics of standing-jump-heading was summarized as follows 1) From comparison between skilled and unskilled groups, skilled subjects showed significantly higher practical displacements during the pre-impact and post-impact phase. 2) The velocities of head and shoulder part of the body were significantly higher in skilled subjects. But focused on the velocity of hip in subjects, negative velocity appeared, change of velocity was lower than unskilled. The higher impact velocities in skilled subjects were seemed that the head and shoulder rotated about center of gravity. 3) It is considered that acceleration at impact is substituted for developed force. Then, the accelerations of head, shoulder and hip in skilled subjects were 14.6, 2.8 and 1.4 time in unskilled subjects, respectively. It is concluded that to perform standing-jump-heading, skilled subjects made their upper bodies and heads rotate strongly about center of gravity.

임신 40주와 출산 후 6주에 있는 20대 임산부 보행의 역학적 특성 비교

윤희중,문동안,정남주,금명숙,이경식,유실,김영란,한윤수 한국운동역학회 2000 한국운동역학회지 Vol.10 No.1

본 연구는 임신 40주와 출산후 6주간에 있는 임산부의 보행 동작의 특정을 규명함으로써 이와 관련된 연구자들에게 기초자료를 제공하고자 실시하였다. 이를 위해 임신 4주에 있는 임산부를 대상으로 1차 실험을 실시하였으며 동일한 대상자를 출산후 6주에 2차로 실험하여 자료를 수집하였다. 디지타이징 시 오차를 최소화하고 인체관절점의 분별을 위해 21개의 반사마커를 부착하였다. 10m의 보행주로를 걷는 동안 두 대의 비디오카메라를 이용하여60Hz로 자료를 수집하였으며 동시에 100Hz 지면반력자료를 수집하였다.수집되어진 자료는 DLT 방법을 사용하여 분석하였으며 이의 분석에 Kwon3d 프로그램을 활용하였다. 분석결과 다음과 같은 결론을 얻었다. 1. 임신 40주와 출산 후 6주의 보행 시 지지시간과 스윙시간의 비율이 다르게 나타났으며 보폭과 보간, 활보장은 임신 40주에서 더 큰 값을 보였다. 상체 전경각 역시 임신 40주에서 더 큰 값을 보였다. 힙관절, 무릎관절, 발목관절각도는 S1이 출산후 6주에서 큰 값을 보인반면 S2는 출산전후에 큰 변화를 보이지 않다. 2. 상하지면반력의 경우 FP1과 FP2는 임신 40주보다는 출산 6주에서 큰값을 보였지만 FP3는 임신 40주에서 보다 큰값을 보이고 있었다. 전후지면반력의 경우 출산전과 후 모두 Fy2에서 보다 큰 값을 보이고 있었다. This Study was to investigate kinematical characteristic comparison of the gait pregnant 40weeks and after delivery 6weeks 20´s women and provide the basic data. To accomplish this study, in the first, carry out an experiment with the pregnant women in the pregnant 40weeks on the videotape, and than the second, make an experiment with the kinematic data. Kinematic data were filtered with a low-pass, fourth-order Butterworth filter with an effective cut off frequency of 6Hz. The conclusions were drawn as follows; 1. Floor contact Periods(stance and swing rate) were differed from before and after the delivery and a pregnant 40 weeks was greater than after delivery 6 weeks in the step, width, stride. Also, a pregnant 40 weeks was greater than after delivery 6 weeks in the front angular. And the other angular components were represented similar pattern. 2. In the vertical load, delivery 6 weeks was grater than a pregnant 40 weeks in the FP1(first peak) and FP2(valley). And FP3(second peak)was represent that a pregnant 40 weeks was greater than delivery 6 weeks. Also, in the horizontal shear, Fy2(progressional force)was greater than Fy1(breaking force) about time of the delivery.

한국과 C.I.S 우수 레슬링 선수들의 엉치걸이 동작에 대한 운동학적 요인 분석

윤희중,전해섭,김동건,김영란 韓國體育大學校附屬 體育科學硏究所 1992 韓國體育大學校附屬 體育科學硏究所論文集 Vol.11 No.1

This study investigated kinemtic factors of hip throw as a representative skill to make a comparative study between Korean and C. I. S wrestlers Four elite wrestlers were filmed using high - speed cinematography. Kinematic data for the each phase were derived from the digitized film. Analyzing variables included center of gravity(CG) displacement and velocity, hip joint, angular displacement and angular velocity The results were as followers ; 1. Elapse time of CG at conducting hip throw were showed similar result between two nations. 2. C. I. S wrestlers showed more displacement than Korean wrestlers in the harizontal phase (P<0.001) but, Korean wrestlers showed large movemnet, in the vertical phase(P <0.001). 3. In average velocity at whole phase, Korean wrestlers showed rapid velocity in the vertical phase(P<0.001) but, C. I. S wrestlers at conducting throw partner down showed rapid velocity in the horizontal phase(P<0.05). 4. C. I. S wrestlers showed large angular displacement in the hip joint at Ph. I. (P <0.001). 5. C. I. S wrestlers showed rapid angular velocity in the hip joint at Ph. I (P<0.001).