학생정신건강검진 시범운영사업에 따른 추진방안

김현정,김윤영,이혜숙,현미나,남동현,김상원,안동현 韓國學校保健學會 2009 韓國學校保健學會誌 Vol.22 No.1

Purpose: The purpose of the study was to·find the strategies of mental health screening in school. Based on the literature review, we discuss the importance of screening students in schools for mental health problems. Methods: Data from the 2008 Korean Mental Health Screening in Schools(2008-KMHSS) are used to estimate the outline of this screening. We administered the questionnaire for satisfaction of 2008-KMHSS for students(N=1,280), parents(N=2,672), school nurses(N=75), teachers(N=685), district personnels(N=6), and mental health center staffs(N=37). Also we interviewed a part of them by telephone and e-mail. And we reviewed the tools and methods for screening students for emotional/behavioral problems. Results: Mental health screening in schools is a very important, yet worrisome, agenda that is in its very early stages. From the 2008 Korean Mental Health Screening in Schools, 9,588 students(12.9%) needed more evaluation in the first stage. Of these, 6,910(72.1%) completed the second stage screening. In this sample, 1,975(28.6%) utilized the mental health services in school or community. 38.3% of students and 43.7% of their parents notified the2008-KMHSS. But only 12.1% of students and 10.9% of their parents dissatisfied with the screening. 9.9% of teachers and 22.7% of school nurses dissatisfied with the screening. Among them the school nurses were mostly dissatisfied, and they complained work burden from KMHSS. Mental health center staffs complained similar issues. The Children's Problem-behavior Screening Questionnaire(CPSQ) and Adolescents' Mental-health & Problem-behavior Screening Questionnaire(AMPQ) were compatible to screen students in schools for mental health problems in first stage. Conclusion: Mental health screening in schools needs careful planning and implementation. For successful mental health screening in schools, several elements need to be considered: careful planning, collaboration, staff training, and integrative mental health programs and services in community or schools.

3-Acetamidophenyl Acetate의 Fries Rearrangement 반응 연구

김동현, 만노즈 마니캄, 풀라레디 보꾸, 이상윤, 조정석, 정상헌 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

Fries rearrangement has been known as highly useful reaction for the synthesis of ortho-or para-hydroxyacylbenzene from phenyl ester in the presence of Lewis acid catalyst. Conventionally, aluminum chloride was used as catalyst. For obtaining N-(4-acetyl-3-hydroxyphenyl)acetamide, 3-acetamidophenyl acetate was subjected to Fries Rearrangement reaction using aluminum chloride. Although the desired N-( 4-acetyl-3-hydroxyphenyl)acetamide was obtained, yield was very low. In addition, regioisomer N-(2-acetyl-5-hydroxyphenyl)acetamide and unexpected N-(2-methyl-4-oxo-4H-chromen-7-yl) acet-amide were obtained. NMR study and conversion to known compollnds confirmed the substitlltion pattern of these phenylacetamides and the structure of chromen-4-ones. Under this Fries Rearrangement condition, formation of chromen-4-one was newly discovered.

6-(3,4-디클로로페닐)아미노-7-클로로-5,8-퀴놀린디온의 항진균작용 및 안전성 평가

윤여표,김동현,이병무,허문영,정해문,강혜영,최정아,김도희,유충규 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

6-(3.4-Dichlorophenyl)amino-7-chloro-5.8-quinolinedione (RCK50) was tested for antifungal activities in mice systemically infected with Candida albicans. The therapeutic potential of RCK50 was also assessed in comparison with ketoconazole. RCK50 had ED_50 0.22±0.01 ㎎/㎏. Ketoconazole as a positive control had ED_50 6.00±1.70 ㎎/㎏. Intraperitoneally administered RCK50 at the ED_50 for 7 days and 14 days reduced Candida albicans colony count in the kidneys and liver. And administered RCK50 at the ED_50 for 14 days improved survival rates. The genotoxicities of RCK50 had been evaluated. RCK50 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. RCK50 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK50 has no genotoxic potential under these experimental conditions. Acute oral toxicity studies of RCK50 were carried out in ICR mice of both sexes. RCK50 did not show acute oral toxicities and LD_50 values were over 2.850 ㎎/㎏ in ICR mice.

약물 유해반응 보고지침 -임상시험의 안전성에 관한 정보 관리지침 -

지동현,김훈교,배진우,손동렬,김인범,전용관,박혜연 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

백색 발광 ZnS 박막 전기장 발광 소자의 제작 및 특성

현동걸,손상호,박태성,이동헌,이상윤 경북대학교 산업기술연구소 1990 産業技術硏究誌 Vol.18 No.-

The basic investigation on ZnS:P_rF_3 thin film electroluminescent devices was done, the phosphor(ZnS:P_rF_3) and the insulator(SiN_X:H) of which were deposited by electron beam evaporation and rf-plasma CVD, respectively. The red(650㎚) and blue(490㎚) light emission peaks were observed in the Electroluminescent spectrum. At the dopant concentration of 0.5mol%, the brightness of 90.6cd/㎡ was obtained under sinusoidal excitation of 1kHz.

콘택트렌즈 보존 용기 유래 Acanthamoeba lugdunensis KA/L5주의 내공생세균

정동일,공현희,김태호,황미열,유학선,윤호철,설성용 경북대학교 의학연구소 1999 경북대학교병원의학연구소논문집 Vol.3 No.1

콘택트렌즈 보존 용기 유래 가시아메바 KA/L5주의 세포질 내에 존재하는 bacterial endosymbiont(내공생세균)를 투과전자현미경으로 관찰하여 확인하였다. 숙주인 가시아메바 KA/L5주는 형태학적으로 제2군에 속하였고, rDNA PCR-RFLP 결과 A. lugdunensis로 동정되었다. 미토콘드리아 DNA RFLP와 동위효소 분석상 이 충주는 국내 콘택트렌즈 보존용기에서 가장흔히 분리되는 type인 KA/Ll주, 국내 임상 분리주 중 하나인 KA/E2주, 내공생세균을 가지는 것으로 보고된 병원 냉각수 유래 KA/W4주 및 L3a주와 동일하거나 매우 유사한 성적을 보였다. 내공생세균은 약 1.38× 0.507㎛의 크기였고, 아메바 세포질 내에 불규칙하게 분포하고 있었으며. 그 표면에 아메바의 ribosome이 부착되어 있었다. 내공생세균을 둘러싼 lacunae나 막과 같은 구조는 관찰되지 않았다. Legionella 특이 primer를 이용한 효소중합반응(PCR)에서 내공생세균의 염색체 DNA는 증폭되지 않았다. A. lugdunensis의 우리말 이름을 담수가시아메바로 제안한다. Transmission electron microscopy of an Acanthamieba isolate (KA/L5) from a contact lens case revealed bacterial endosymbionts within cytoplasm of the amoebae, The Acanthamoeba isolate belonged to the morphological group II. Based on the polymerase chain reaction (PCR) - restriction fragment length Polymorphism (RFLP) of 18S ribosomal RNA coding DNA (rDNA), the Isolate was identified as A. lugdunensis. Strain typing by isoenzyme analysis using isoelectric focusing (IEF) and mitochondrial (Mt) DNA RFLP revealed that the isolate was closely related with KA/Ll , the most predominant type of isolates from contact lens storage cases, KA/E2, a clinical isolate, KA/W4, preciously reported to host endosymbionts, and L3a strains of A. lugdunensis. The endosymbionts were similar to those of KA/W4 In aspects that they were randomly distributed in both trophozoites and cysts, and were rod-shaped bacteria measuring approximately 1.38x 0.50㎛. But the number of endosymbionts per amoeba was significantly lower than that of KA/W4. They were neither limited by phagosomal membranes nor included In lacunae- like structure.

편두통 환자의 임상 양상 및 생체전기 자율반응과의 상관성 고찰

이현종,정인태,김수영,이두익,김건식,이재동,이윤호,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : We had a clinical report in headache but didn't in migraine. We have planned this study in order to get the basic data of migraine in oriental medicine. Methods : The patient of 36 in migraine checked sec, age, onset, family history, severity of pain, influences of life, induced cause, clinical pain characteristics, associated symptom, treatment style, and paescription, frequency, using period of analgesics by a questionnaire and differentiated syndromes in migraine and evaluated autonomic bioelectric response recorder(ABR-2000). Results : There are 23.4% in prevalence rate of migraine. The ratio of sex is M: F=1:17. The age of an attack is the highest in thirties. The patient are the most in forties. The mean duration of illness is 12.0±9.9 years. 83.4% had a family history. 61.1% had a moderate grade in severity of pain. 77.8% selected fatigue in induced cause of migraine. 69.4% had tingling sense, nausea and vomiting in the associated symptoms. 91.7% used analgesics for treatment and 51.5% of them used analgesics voluntarily. 61.9% of them take analgesics less than once in a week. 33.6% had the phlegm syncope headache in differentiation of syndrome. In ABR-2000 results, item of graph showed low tendency mostly. Conclusions : We expected that this re port of clinical progress, differentiation of syndromes and ABR-2000 results in migraine would be used basic data by oriental medicine to treat migraine.

만성두통 환자의 성격유형 A 행태, 스트레스, 우울 및 두통영향정도의 관계 연구

차남현,임사비나,정인태,김수영,안경애,김건식,이재동,이상훈,최도영,이윤호,이두익 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

To examine an estimate factor and grasp the relation of difference for Ype A Behavior Pattern(TABP), Perceived Stress Questionnaire. Depression and HIT-6 in the Chronic headache client. Method: Data collected by self-reported questionnaires from 38 client in S city who were selected by criteria of IHS, from the 19^(th) of October to 10^(th) of December, 2004. Result: 1) Differences between biographical data by TABP was significant by SaSang constitutions, by Stress was significantly influenced by age, and by Depression were significantly influenced health status and SaSang constitutions. 2) Correlations Coefficients among Study Variables were Stress and Depression(r=.494, p=.002) and Depression and HIT-6(r=.432, p=.010). 3) In regression analysis, HIT-6 were significantly influenced by Depression and Type A Behavior Pattern(TABP). These variables explained 38% and 34% respectively. Conclusion: The result suggest that chronic headache management with psychological aspect, as well as physical aspect should be a focus to enhance the quality of life.

전문비서란 무엇인가? : Its Concept and Function

김주연,용주현,신동희,유민,최정윤 이화여자대학교 법정대학 비서학과 1995 비서학연구 Vol.- No.15

농촌지역의 주의력결핍-과잉행동장애와 학습장애의 역학적 연구

김자윤,안동현,신영전 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 농촌지역 초등학생의 주의력결핍-과잉행동장애와 학습장애, 정신지체의 유병률을 조사하고, 보다 효과적인 장애아동 발견방법을 구하기 위해 연구를 계획하였다. 방 법 : 경기도 일개 군내 5개 면의 6개 초등학교, 1,256명에서 전체 학생을 대상으로 교사가 설문지를 작성한후 이를 통해 1차 선별하는 전수(total population) 조사방법과 교사가 직접 1차 선별하는 핵심요원(Key informant) 조사방법을 이용해 문제아동을 선별하였고, 대상아동은 현장을 방문해 정신과적 면담이나 지능검사를 통해 확진하였다. 결 과 : 1) 유별률은 주의력결핍-과잉행동장애가 1.99%, 학습장애가 0.40%, 경도이상의 정신지체가 2.23%이었다. 2) 전수 조사와 핵심요원 조사를 비교하면, 전수 조사의 경우 경도 이상의 정신지체의 유병률이 유의하게 높은 것(전수 조사 3.29%, 핵심요원 조사 1.23%) 외에 핵심요원 조사와 유별률에서 유의한 차이는 없었다. 핵심요원 조사는 주의력결핍-과잉행동장애와 정신지체 등에 의한 학습부진의 양성 예측도가 전수 조사에서 사용된 파탄적 행동장애 평정 척도(Disruptive Behavior Disorders Rating Scale, DBDRS)나 학업 수행 평정 척도(Academic Performance Rating Scale, APRS)보다 높았다(DBDRS : 전수 조사 17.33%, 핵심요원 조사 41.67% ; APRS : 전수 조사 39.22%, 핵심요원 조사 44.44%). 진단 받은 아동만을 비교할 때 두 집단의 질병분포에서 유의한 차이는 없었다. 3) 부모와 교사가 다같이 아동의 문제를 인식하고 있을 때 실제 장애의 가능성이 높았다. 결 론 : 조사된 시점유병률은 주의력결핍-과잉행동장애가 1.99%, 학습장애, 정신지체가 각각 0.40%와 2.23%였다. 양성예측도와 진단별 일치도로 비교할 때 핵심요원을 이용한 조사가 장애아동 발견에 보다 효율적이었다. 장애아동 발견에 있어 교사 혹은 부모의 단일 경로의 정보는 신뢰도가 상대적으로 낮았고 두 경로를 합쳤을 때 신뢰도가 더욱 높아짐을 볼 수 있었다. 이 연구의 결과는 우리 나라 초등학생에서 주의력결핍-과잉행동장애와 정신지체의 유병률을 조사했다는 의의와 함께, 향후 학교 대상의 역할조사에서 핵심요원 조사방법의 유효성을 증명하는 것이다. Objectives : We atlempted to determine the prevalence rate of attention deficit-hyperactivity disorder, learning disorder, and mental retardation of elementary school children in a rural area, and to evaluate a cost, and time-efficient method for identifying of children with such disabilities. Methods : We studied 1,256 children from 6 elementary schools in a rural aiea using used two-stage design. At the first step, we used the key informant and the total population survey methods for identifying children with disability. Teacher checklists were used as screening instru-ments in total population survey. And at the second step, child interview and KEDI-WISC were employed to make diagnoses. Results : 1) The prevalence rate of attention-deficit/hyperactivity disorder(ADHD) was 1.99%. The prevalence rates of learning disorder(LD) and mental retardation(MR) were 0.40% and 2.23%, respectively. 2) The prevalence rate of MR was significantly higher in total population method compared with key informant method(3.29% vs. 1.23%). Other comparison of prevalence rates in two methods was not significantly different. Positive predictabilities of ADHD and learning disabilities by key informants were higher than by DBDRS and APRS, the checklists used in total population methods. 3) The probability of illness was much higher when the teacher and parents reported the problems of child concurrently. Conclusions : The prevalence rate of ADHD in elementary school children in the rural area was 1.99%. And the prevalence rates of LD and MR were 0.40% and 2.23%, respectively. Key informant method was more effective compared with total population survey in positive predictability and diagnostic concordance, In identifying children with disabilities, the combined data from teacher and a parent was most reliable.