폐장암에서 p53과 PCNA 표출에 관한 연구

김대중,양승하,정도영,강상균,김의한 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

To observe the expression of p53 protein and PCNA in lung carcinomas and to evaluate the correlationship between the two results, the author has been carried out immunohistochemical staining with mononuclear antibodies against p53 and PCNA. 64 cases of lung carcinomas used consist of 32 cases of squamous cell carcinomas, 18 cases of adenocarcinomas and 14 cases of small cell carcinomas, respectively. 1. p53 protein expression was seen in 16 cases out of 32 (50%) in squamous cell carcinoma, 7 cases out of 18 (39%) in adenocarcinoma and 10 cases out of 14 (71%) in small cell carcinoma. The positive rate of p53 is highest in small cell carcinoma. 2. p53 staining degrees showed that 3+ in 75% of squamous cell carcinoma, 1+ in 58% of adenocarcinoma and 1+ in 50% in small cell carcinma. were observed. The tumor cell composing of squamous cell carcinoma showed most strong staining to p53 protien. 3. PCNA labelling index showed higher index in p53(+) cases than p53(-) cases. The PCNA index of squamous cell carcinoma was highest and adenocarcinoma and small cell carcinoma in order. Above findings suggested that the PCNA index was related to p53 protein in tumor cells, but the PCNA index appeared to be influenced by the p53 protein content in tumor cells than whether the p53 protien was or not. So the growth rate of squamous cell carcinoma appeared to be most rapid than adenocarcinoma and small cell carcinoma.

실천신학 : 교단 분열 이전의 한국성결교회 전도활동에 관한 연구 ?1945년~1961년

하도균 ( Do Kyun Ha ) 서울신학대학교 기독교신학연구소 2014 神學과 宣敎 Vol.45 No.-

본 논문은 해방 이후부터 교단이 분열되기 이전까지 한국성결교회의 전도활동에 관한 논문이다. 한국성결교회는 전도하면서 세워진 교단이라는 자부심이 있지만, 교단 정신의 정체성이 되는 전도활동에 관한 연구가 학문적으로 체계적으로 이루어지지 못하였다. 필자가 박사논문으로 연구한 주제인 “해방 이전의 초기 한국성결교회의 전도활동에 관한 연구”가 유일하였다. 이에 본 논문은 초기 성결교회의 전도활동에 관한 연구의 맥을 이어, 해방 이후부터 교단 분열 이전까지의 전도활동을 연구하여 한국성결교회의 전도의 흐름과 발전을 위한 초석을 놓고자 하였다. 기본적인 연구가 선행되지 못하고는 학문적인 연구와 발전이 전무할 수밖에 없기 때문이다. 이 시기의 전도활동의 특징은 첫째, 초기 성결교회의 전도활동의 맥을 이어 직접전도가 활성화되고 있었다는 점이다. 교단이 중심이 되어 각각의 전도대(傳道隊)를 조직하여 운영하였으며, 또한 교단의 각 기관을 통하여 직접전도활동을 하기도 하였다. 특별히 이성봉 목사라는 걸출한 전도자의 활동으로 초기성결교회의 전도모습에 견줄 정도로 활발하게 직접전도활동이 실천되었다. 또한 교단의 희년을 맞이하여 희년전도대를 조직하여 활동하기도 하였다. 둘째, 해방 이후 국내의 어려운 현실적 상황에 직면하여 간접전도가 활성화되기 시작하였다. 엘마 길보른이 조성한 기금으로 자금 확보가 선행되었고, 또한 동양선교회 J. B. 크라우스가 세계구호위원회의 일원으로 활동하며 막대한 구호금과 구호품들의 국내 공급 통로가 되면서 성결교회의 간접전도활동은 더욱 활성화되었다. 성결교회는 교육사업과 사회사업을 서서히 전개하다가 나라를 재건하는 구호사업에 본격적으로 뛰어들게 된 것이다. 셋째, 이 시기의 간접전도활동의 활성화는 직접전도의 정신을 약화시키는 결과도 초래하여 교단 분열의 불씨가 되기도 하였다. 지혜롭게 처리하였다면, 통전적인 안목에서 균형 잡힌 전도 활동을 실천할 수 있었으며 더 발전된 전도활동과 결과를 낳을 수 있었지만 결과는 그렇지 못하였다. 본 논문의 연구를 통하여 한국성결교회에서 전도활동이 교단에 끼치는 영향이 얼마나 지대한지 다시 한 번 확증되었다. 적어도 교단분열 이전까지는, 전도활동이 성결교단을 이해하고 성장시키며 심지어는 분열에까지 지대한 영향을 끼친 것이다. 이에 본 논문과 같은 선행적인 연구들을 기초로 전도활동에 관한 더 발전적인 연구가 있어지기를 기대한다. This paper is about the evangelistic activities of the Korea Holiness Church before the denominational Split. The Korean Holiness Church has self-esteem called the communion built through evangelism, but there was not study of evangelistic activities that become identity of the communion mind systematically. “Research on the Evangelistic Activities of the early Korea Holiness Church before the liberation” which is the writer`s doctoral dissertation is unique. Hereupon, this paper would like to lay the foundation stone for the advancement of the evangelism of the Korea Holiness Church by studying of the evangelistic activities of the Korea Holiness Church before the denominational Split followed the research on the Evangelistic Activities of the early Korea Holiness Church. That`s why there are no scientific study and development without basic research is preceded. The first characteristic of the evangelistic activities on this time is that direct evangelism is invigorated after the evangelistic activities of the early Korea Holiness Church. The communion organized each missionary team actively, also the direct evangelistic activities are progressing thorough each institution of the communion. Especially, the direct evangelistic activities were practiced enough to compare in the evangelism of the early Kore Holiness Church by work of the Reverend Lee sung bong who is a prominent evangelist. Also, ‘the year of jubilee-missionary team’ was organized and worked on positive lines for the year of jubilee of the communion Second, indirect evangelism was begun to activate facing in domestic difficult realistic circumstance after liberation. Because the security of funds was preceded by the fund which Elmer Kilborun has raised, and also J.B. Crouse was engaged as a member in World Relief Committee. As a result, the indirect evangelistic activities of the Korea Holiness Church were activated better becoming the domestic supply passageway of huge alms and supplies. The Korea Holiness Church is jumped in relief work that reconstruct the country in earnest while developing educational work and social work slowly. Third, the activation of indirect evangelistic activities on this time caused the result that weaken the spirit of direct evangelism. This result is the cause of the Denominational Split. If this problem was handled wisely, the Korea Holiness Church could practice a balanced evangelistic activities in a holistic perspective, and could produce improved evangelistic activities and better results. How enormous the effect that evangelistic activities have influenced the communion in the Korea Holiness Church is confirmed again through the research of this paper. At least, evangelistic activities have helped the growth of the Korea Holiness Church until the Denominational Split, and even had great influence on the Denominational Split. Hereupon, I expect that more expansive study about evangelistic activities which is based on advanced researches such as this paper is continued.

웨슬리안 성령운동가로서의 플레쳐에 관한 연구

하도균(Do Kyun Ha) 한국기독교학회 2010 한국기독교신학논총 Vol.70 No.-

Even though he failed to become a successor to Wesley because he passed away earlier than Wesley, John Fletcher has been regarded as the first Wesleyan theologian and was designated by Wesley as his successor. The reason why Fletcher has been called the first Wesleyan theologian is that as a contemporary to Wesley, he not only interpreted, defended and advocated for Wesley`s theology against critics in the Reformed traditions, but also had an influence on them. Besides, he was a man who told people of the doctrine of Christian perfection which was Wesley`s theology. He successfully made them focus on it. However, rather than being treated as the first Wesleyan theologian, Fletcher has been judged as a theologian with his own theological logic. This is because unlike Wesley, as an activist of the Holy Spirit he emphasized Pentecostal tongues and insisted on the concept of Christian perfection by the Holy Spirit. However, we cannot decide rashly whether Fletcher took his own logic diametrically opposed to Wesley`s by emphasizing the Holy Spirit, or whether he expanded his own theology based on Wesley`s theology as a supplement to Wesley`s view. If Fletcher had stood distinctly apart from Wesley, Wesley would not have named Fletcher as his successor and would not have consented to Fletcher`s writings. Accordingly, this article has compared and analyzed the common grounds and differences between Fletcher`s conception of Christian perfection centered on the Holy Spirit and that of Wesley, based on Christian perfection which is a central concept of Wesley`s theology. Also, this article has clarified that although there are a few differences between them, Fletcher`s notions were not totally different concepts from Wesley`s, but points that Wesley had agreed with and approved. Furthermore, this article has illuminated how Wesley`s theology and Pentecostal theology can be connected, and has suggested a research project on how Wesleyan theology can accept Pentecostal tongues, embrace Pentecostal theology, and develop further. Finally, this article has dealt with the disputes and contributions of Fletcher as a true Wesleyan theologian, mentioning the common grounds and differences between Fletcher and Wesley.

The association between migraine and Parkinson’s disease: a nationwide cohort study in Korea

Woo-Seok Ha(Woo-Seok Ha),Jaeho Kim(Jaeho Kim),Hee Won Hwang(Hee Won Hwang),Sue Hyun Lee(Sue Hyun Lee),Ji In Kim(Ji In Kim),Jin Yong Hong(Jin Yong Hong),Sang Hyun Park(Sang Hyun Park),Kyung Do Han(Kyun 한국역학회 2024 Epidemiology and Health Vol.46 No.-

A Piezoelectric Energy Harvester with High Efficiency and Low Circuit Complexity

Do, Xuan-Dien,Nguyen, Huy-Hieu,Han, Seok-Kyun,Ha, Dong Sam,Lee, Sang-Gug The Institute of Electronics and Information Engin 2015 Journal of semiconductor technology and science Vol.15 No.3

This paper presents an efficient vibration energy harvester with a piezoelectric (PE) cantilever. The proposed PE energy harvester increases the efficiency through minimization of hardware complexity and hence reduction of power dissipation of the circuit. Two key features of the proposed energy harvester are (i) incorporation synchronized switches with a simple control circuit, and (ii) a feed-forward buck converter with a simple control circuit. The chip was fabricated in $0.18{\mu}m$ CMOS processing technology, and the measured results indicate that the proposed rectifier achieves the efficiency of 77%. The core area of the chip is 0.2 mm2.

Thermoset polymers consisting of novolac and melamine derivatives as insulators for organic thin-film transistors

Ha, Jong-Woon,Jang, Jae-Ho,Kim, Yongnam,Lee, Jin-Kyun,Kwak, Jeonghun,Hwang, Do-Hoon The Royal Society of Chemistry 2015 Journal of Materials Chemistry C Vol.3 No.15

<▼1><P>A potential gate dielectric material that can be cured and processed at low temperatures was designed and synthesized <I>via</I> the cross-linking of bisphenol A novolac (Novolac) and hexamethoxymethylmelamine (HMMM) in the presence of a catalytic amount of <I>p</I>-toluenesulfonic acid.</P></▼1><▼2><P>A potential gate dielectric material that can be cured and processed at low temperatures was designed and synthesized <I>via</I> the cross-linking of bisphenol A novolac (Novolac) and hexamethoxymethylmelamine (HMMM) in the presence of a catalytic amount of <I>p</I>-toluenesulfonic acid. The thin films of the prepared insulator, Novolac-MM, were completely solidified after cross-linking at 100 °C. Metal–insulator–metal (MIM) devices and pentacene-based p-type organic thin-film transistors (OTFTs) using the synthesized polymer as a dielectric layer were fabricated and compared to poly(vinylphenol)-based materials. Novolac-MM devices showed low leakage current (<10<SUP>−8</SUP> A cm<SUP>−2</SUP>) and higher hole mobility (0.31 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>) than PVP devices (0.23 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>). Flexible OTFTs using Novolac-MM were also fabricated, and were found to be processable at low temperatures.</P></▼2>

Sequential Induction of Ethylene, Lipoxygenase, and Ascorbate Peroxidase in Senescing Soybean Callus

Ha, Mi-Young,Kim, Do-Kyun,Kim, Soon-Young,Kang, Bin-G.,Oh, Seung-Eun Korean Society for Biochemistry and Molecular Biol 1996 Journal of biochemistry and molecular biology Vol.29 No.6

Bursts of ethylene production occurred in twice at an early exponential (EEP) and prestationary (PSP) phases, respectively, during growth of callus tissue isolated from the root of soybean seedlings. The second burst of ethylene production at PSP was smaller in magnitude than the earlier one at EEP, but was followed by increases in both guaiacol peroxidase (GuPOX) and ascorbate peroxidase (AsPOX). The increase in AsPOX activity was also preceded by an increase in lipoxygenase (LOX) activity. Treatment of the tissue with the ethylene antagonist 2,5-norbonadiene (NBD) resulted in substantial reduction in LOX and AsPOX activities during this period. GuPOX activity was reduced only slightly, if any, by NBD. Role of ethylene in the sequential induction of LOX and AsPOX in senescing callus tissue is discussed.

Prevalence of Brachyspira hyodysenteriae on selected swine farms in Gyeongbuk province by PCR

( Dong Kyun Suh ),( Yun Jeong Do ),( Jong Su Ha ),( Kyeong Hyeon Lee ),( Yoo Jung Cho ),( Dong Jun Song ),( Chun Sik Lee ),( Young Chan Bae ),( Won Pil Choi ),( Keun Woo Lee ),( Jae Chan Song ) 한국동물위생학회 2001 한국동물위생학회지 (KOJVS) Vol.24 No.4

The purpose of this study is to determine the prevalence of Brachyspira hyodysenteriae from 43 swine farms with diarrhea or a history of diarrhea in Gyeongbuk province by PCR. The overall herd prevalence of B hyodysenteriae was 37.2%(16/43), and the average prevalence of B hyodysenteriae among all sampled pigs was 10.8%(50/462). Positive herds for B hyodysenteriae were distributed throughout Gyeongbuk province from 14.3~50%. Herd size had A effect on the frequency of B hyodysenteriae. The frequency of B hyodysenteriae in herds with less than 1,000 pigs was 47.4%, That of herds between 1,001 and 2,000 pigs was 41.7%. Also, the frequency of B hyodysenteriae in herds with more than 2,000 pigs was 16.7%.

한국인의 정상안에서의 동공반응시간과 동공면적

김도균(Do Kyun Kim),반민섭(Min Soap Ban),유중하(Joong Ha Yoo) 대한안과학회 1999 대한안과학회지 Vol.40 No.10

양식산 황복에서 tetrodotoxin 유사 독소의 미량 존재 가능성 제시

김도영 ( Do Young Kim ),김주완 ( Ju Wan Kim ),박기석 ( Ki Seok Park ),강희웅 ( Hee Woong Kang ),전중균 ( Jooong Kyun Jeon ),정준기 ( Joon Ki Chung ),최상훈 ( Sang Hoon Choi ),최민순 ( Min Soon Choi ),박관하 ( Kwan Ha Park ) 한국어병학회 2009 한국어병학회지 Vol.22 No.1