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스테로이드 의존형 신증후군과 동반된 기무라병에서 cyclosporine 치료 경험
도영선,김학용,남궁미경,Do, Young-Sun,Kim, Hak-Yong,NamGoong, Mee-Kyung 대한소아신장학회 2009 Childhood kidney diseases Vol.13 No.2
저자들은 스테로이드 의존형 신증후군 환자에서 진단 8년 만에 두경부 종물이 발생, 혈액 검사상 IgE 증가와 호산구 증가, 경부 컴퓨터 단층 촬영으로 기무라병을 진단하였고, 스테로이드로 치료하였으며, cyclosporine을 투여한 이후 장기간 두경부 종물과 신증후군의 재발을 억제할 수 있었기에 문헌고찰과 함께 보고하는 바이다. Kimura's disease is a chronic inflammatory disorder of unknown etiology. A 14 year old boy suffering from steroid dependant nephrotic syndrome, was presented with relapsing painless subcutaneous masses on the left buccal area. Blood analysis showed increased IgE and eosinophilia. During 4 years follow up, he was been treated by low dose steroid and short term cyclosporine. Consequently, frequent relapses of subcutaneous masses and nephrotic syndrome has been relieved. Cyclosporine treatment combined with steroid may be useful for preventing frequent relapse of Kimura's disease.
Effects of Ketotifen on an Experimental Model of IgA Nephropathy
도영선,순유진,남궁미경,Do, Young-Sun,Soon, Eu-Jene,NamGoong, Mee-Kyung Korean Society of Pediatric Nephrology 2009 Childhood kidney diseases Vol.13 No.2
목적 : 장점막 손상은 IgA 신증의 병리기전중의 하나로 알려져 있다. 구강항원은 보통 Th2 세포와 비반세포를 활성화 시킨다. 이러한 세포들은 IL-4, IL-5 TGF-${\beta}$와 같은 싸이토카인들을 분비하여 IgA 생성을 증가시킨다. 케토티펜(benzpxycloheptathiophene)은 H1항체이자 비반세포의 막안정제로 IL-4, IL-5, PGE2, LTB4 등의 생산을 억제하고, 질산화산소합성제의 활성화를 감소시켜 위장관막을 보호한다. 저자들은 구강항원으로 인한 IgA 신증의 발병을 케토티펜이 예방할 수 있는지 관찰하였다. 방법 : ICR 생쥐를 이용하여 구강 폴리오백신(백신군)을 투여하면서, 다른 군에서는 케토티펜(케토티펜군)을 백신과 동시에 투여하였다. 결과 : 메산지움의 IgA 침착은 백신군에서 18마리중 11마리에서 발생하였으나, 케토티펜군에서는 9마리 중 3마리에서 볼 수 있었다. 메산지움의 조직 변화는 백신군에서 18마리 중 16마리, 케토티펜 군에서는 9마리 중 5마리에서 볼 수 있었다. 혈청 IL-4, IL-5치는 케토티펜 군에서 백신군과 비교해 다소 낮기는 하지만 의미있는 감소는 하지 않았다. 결론 : 케토티펜은 IgA 신증의 사구체 변화를 감소시키는데 유효한 것으로 사료된다. Purpose : The intestinal mucosal defect has been known as one of the pathogenicmechanisms of IgA nephropathy. Oral antigens usually induce the activation of Th2 cells and mast cells. These cells secrete cytokines IL-4, IL-5 and TGF-$\beta$, which increase IgA production. Although ketotifen (benzocycloheptathiophene) is an H1 antagonist and a mast cell membrane stabilizer, it could protect the gastrointestinal membrane through inhibiting the production of IL-4, IL-5, PGE2, and LTB4, and decreasing the activity of nitric oxide synthease. Therefore, we have investigated if ketotifen may protect the development of IgA nephropathy with an oral antigen. Methods : ICR mice were used as an animal model orally with Poliovax only [ketotifen (-)], the other group was given oral ketotifen [ketotifen (+)] in addition to Poliovax. Results : Mesangial IgA deposition developed in 11 out of the 18 mice in the ketotifen (-) group, while in three out of the nine mice in ketotifen (+) group. The mesangial change developed in 16 out of the 18 mice in the ketotifen (-) group, while in five out of the nine mice in the ketotifen (+) group. Serum IL-4 and IL-5 levels were not significantly lower in the latter group than in the former. Conclusion : According to the statistical results from the above, ketotifen therapy would be beneficial to reducing mesangial changes in IgA nephropathy.
잉어의 생체 내 대사체 변화에 미치는 플록세틴 영향규명 연구
정인영 ( In-young Chung ),박유미 ( Yu-mi Park ),김상민 ( Sang-min Kim ),김일규 ( Il-gyu Kim ),도영선 ( Young-sun Do ),김석만 ( Suhkmann Kim ),한상범 ( Sang Beom Han ),조현덕 ( Hyun-deok Cho ),석광설 ( Kwang-seol Seok ) 한국환경분석학회 2017 환경분석과 독성보건 Vol.20 No.1
The purpose of this study was to clarify the effect of fluoxetine, one of the most frequently prescribed antidepressant drugs, on Cyprinus carpio by comparing the variations in its metabolite concentrations after exposure to the drug, using NMR and LC/Orbitrap MS. Three experimental reactors were employed, and the total experimental period was 14 days. Cyprinus carpio were acclimatized for 3 months in the laboratory and then subjected to the study. One reactor was used as a 14-day control, and the others were exposed to fluoxetine at 10 ng/L and 10 μg/L for 7 days and depurate for 7 days. The variations in metabolite concentration after exposure were analyzed by NMR and LC/Orbitrap MS. Before exposure, the concentration trends of fluoxetine and its main metabolite, norfluoxetine were almost the same in blood and liver samples of Cyprinus carpio. However, after the depuration period, the concentrations of norfluoxetine in the liver and blood samples were higher than those of fluoxetine. The concentration of the remaining norfluoxetine in the liver sample was higher than that in the blood sample. This means that the liver mainly metabolized pharmaceuticals. The main change in the concentrations of metabolites of Cyprinus carpio was shown in amino acids such as leucine, isoleucine, glutamate, tyrosine, and valine; organic acids such as acetate and formate; creatine; and glucose. Although after the depuration period, the control, and 10 ng/L and 10 μg/L exposure groups had overlapping results, the exposure and control groups could be classified clearly after 14 days. These results are expected to contribute to identifying the effects of environmental pollutants by tracing metabolite changes and building a chemical metabolite database.
고상추출법과 액액추출법을 이용한 수질 시료 중 Hexabromocyclododecanes (HBCDs) 분석법 연구
이두희 ( Hye Ri Lee ),정인영 ( In-young Chung ),이혜리 ( Hye Ri Lee ),김혁 ( Hyuk Kim ),박상아 ( Sang-ah Park ),김일규 ( Il-gyu Kim ),도영선 ( Young-sun Do ),이원석 ( Won Seok Lee ),최종우 ( Jong Woo Choi ) 한국환경분석학회 2016 환경분석과 독성보건 Vol.19 No.2
In this study, we evaluated analytical methods for the determination of three hexabromocyclododecane diastereomers (α, β, γ-HBCD) using solid-phase extraction (SPE) and liquid-liquid extraction (LLE). Instrumental analysis was conducted using high-performance liquid chromatography with a triple-quadrupole mass spectrometer (LC/MS/MS), and the hydrophilic-lipophilic balance (HLB) cartridge was used for SPE. SPE showed the highest recovery when using ethyl acetate as the eluent, and 40% methanol was used as the clean-up solvent. In LLE, a multilayer column using AgNO3 showed a low recovery rate. The respective method detection limits (MDLs) and the limits of quantitation (LOQs) of HBCDs in water were 0.068-0.145 ng/L and 0.217-0.462 ng/L for SPE, and 0.043-0.293 ng/L and 0.135-0.932 ng/L for LLE. The accuracy ranged from 96.3% to 104.3% for SPE and 99.3% to 101.2% for LLE. The precision values for both SPE and LLE were less than 5.98%.