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Huh, Jeong-Eun,Lee, Wong In,Kang, Jung Won,Nam, Dongwoo,Choi, Do-Young,Park, Dong-Suk,Lee, Sang Hoon,Lee, Jae-Dong American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.11
<P>Formononetin (<B>1</B>), a plant-derived phytoestrogen, possesses bone protective properties. To address the potential therapeutic efficacy and mechanism of action of <B>1</B>, we investigated its antiosteoclastogenic activity and its effect on nuclear factor-kappaB ligand (RANKL)-induced bone-marrow-derived macrophages (BMMs). Compound <B>1</B> markedly inhibited RANKL-induced osteoclast differentiation in the absence of cytotoxicity, by regulating the expression of osteoprotegerin (OPG) and RANKL in BMMs and in cocultured osteoblasts. Compound <B>1</B> significantly inhibited RANKL-induced tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, monocyte chemoattractant protein-1 (MCP-1), regulated on activation normal T cell expressed and secreted (RANTES), and macrophage inflammatory protein-1α (MIP-1α) in a concentration-dependent manner. These effects were accompanied by a decrease in RANKL-induced activation of the NF-κB p65 subunit, degradation of inhibitor κBα (IκBα), induction of NF-κB, and phosphorylation of AKT, extracellular-signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK). NF-κB siRNA suppressed AKT, ERK, JNK, and p38 MAPK phosphorylation. Furthermore, <B>1</B> significantly suppressed c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), key transcription factors during osteoclastogenesis. SP600125, a specific inhibitor of JNK, reduced RANKL-induced expression of phospho-c-Jun, c-Fos, and NFATc1 and inhibited osteoclast formation. These results suggested that <B>1</B> acted as an antiresorption agent by blocking osteoclast activation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-11/np500417d/production/images/medium/np-2014-00417d_0007.gif'></P>
Non-Bonded Interaction Effects on Cis-Trans Isomerization of 1-Bromopropene
Huh, Do-Sung,Jung Kyung-Hoon Korean Chemical Society 1992 Bulletin of the Korean Chemical Society Vol.13 No.1
The hindered internal rotation effect of methyl group on chemical reaction was studied for cis-trans isomerization reaction of 1-bromopropene system using RRKM technique. A comparative study of the isomerization rates was also performed between the rigid and allowed internal rotations. The calculated rate of rigid cis-trans isomerization of 1-bromopropene was shown to be three times higher than its other halogenated propene homologues with its internal rotations and found to be in good agreement with experimental observations. These findings could be explained reasonably well in terms of the differences of the rotational barrier heights among halogenated propenes and correlated with the relatively low internal rotation barrier of cis-1-bromopropene, 230 cal/mol, compared to those of other cis-1-halopropenes, 700-800 cal/mol, and trans-1-halopropenes, 2.0-2.4 kcal/mol.
Huh, Do-Sung,Choe, Sang-Joon,Lee, Burm-Jong Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.2
In this study, the dependency of the behavior of propagating front on the reaction condition in frontal polymerization reaction has been studied. We have used some multifunctional acrylates as a monomer and ammonium persulfate as an initiator for the polymerization reactions. In frontal polymerization, a method of producing polymeric materials via a thermal front that propagates through the unreacted monomer/initiator solution, the behavior of self propagating front shows various dynamic patterns depending on the reaction condition. We have obtained some spin modes of propagating front in the number of 'hot spots' or 'spin heads' by changing the reaction condition. The effect of the reactor tube diameter on the mode of propagating front has also been studied by using some reactor tubes with different size of tube diameter and it has been examined in some detail by adopting an experimental method of two-tubes system.
Intracranial Atherosclerotic Disease; Current Options for Surgical or Medical Treatment
Huh, Pil-Woo,Yoo, Do-Sung The Korean Neurosurgical Society 2007 Journal of Korean neurosurgical society Vol.42 No.6
Recently, intracranial atherosclerosis has become a major cause of ischemic stroke, appearing more frequently in Koreans than Caucasians. Symptomatic or asymptomatic intracranial atherosclerosis is a disease that could recur readily even during the treatment with anti-platelet agents. When the symptoms develop, ischemic stroke can not be recovered readily. Therefore, aggressive treatments such as endovascular therapy and bypass surgery are required in addition to medical treatment for the intracranial artery stenosis. Recent intracranial stenting and drug eluting stenting have shown as very advanced effective therapeutic modalities. Nevertheless, until now, a randomized controlled study has not been conducted. Regarding bypass surgery, since the failed EC-IC bypass surgery study performed 20 years ago, extensive studies on its efficacy has not been conducted yet, and thus it has to be performed strictly only in hemodynamically compromised patients. Unless breakthrough drugs that suppress the progression of intracranial atherosclerosis and the formation of thrombi, and facilitate the regression of the arterial stenosis, the treatment concept of the recovery of the blood flow of stenotic arterial territory by mechanical recanalization or bypass surgery would be remained for the prevention as well as treatment of ischemic stroke caused by intracranial atherosclerosis.
Huh, Joon,Yang, Seo-Yeon,Huh, Han-Yong,Ahn, Jae-Kun,Cho, Kwang-Wook,Kim, Young-Woo,Kim, Sung-Lim,Kim, Jong-Tae,Yoo, Do-Sung,Park, Hae-Kwan,Ji, Cheol The Korean Neurosurgical Society 2018 Journal of Korean neurosurgical society Vol.61 No.1
Objective : Massive intracerebral hemorrhage (ICH) and major infarction (MI) are devastating cerebral vascular diseases. Decompression craniectomy (DC) is a common treatment approach for these diseases and acceptable clinical results have been reported. Author experienced the postoperative intracranaial pressure (ICP) trend is somewhat different between the ICH and MI patients. In this study, we compare the ICP trend following DC and evaluate the clinical significance. Methods : One hundred forty-three patients who underwent DC following massive ICH (81 cases) or MI (62 cases) were analyzed retrospectively. The mean age was $56.3{\pm}14.3$ (median=57, male : female=89 : 54). DC was applied using consistent criteria in both diseases patients; Glasgow coma scale (GCS) score less than 8 and a midline shift more than 6 mm on brain computed tomography. In all patients, ventricular puncture was done before the DC and ICP trends were monitored during and after the surgery. Outcome comparisons included the ictus to operation time (OP-time), postoperative ICP trend, favorable outcomes and mortality. Results : Initial GCS (p=0.364) and initial ventricular ICP (p=0.783) were similar among the ICH and MI patients. The postoperative ICP of ICH patients were drop rapidly and maintained within physiological range if greater than 80% of the hematoma was removed. While in MI patients, the postoperative ICP were not drop rapidly and maintained above the physiologic range (MI=18.8 vs. ICH=13.6 mmHg, p=0.000). The OP-times were faster in ICH patients (ICH=7.3 vs. MI=40.9 hours, p=0.000) and the mortality rate was higher in MI patients (MI=37.1% vs. ICH=17.3%, p=0.007). Conclusion : The results of this study suggest that if greater than 80% of the hematoma was removed in ICH patients, the postoperative ICP rarely over the physiologic range. But in MI patients, the postoperative ICP was above the physiologic range for several days after the DC. Authors propose that DC is no need for the massive ICH patient if a significant portion of their hematoma is removed. But DC might be essential to improve the MI patients' outcome and timely treatment decision.
New Unified Viscoelastic Constitutive Equation for Asphalt Binders and Asphalt Aggregate Mixtures
Huh, Jung Do,Mun, Sung Ho,Huang, Shin-Che American Society of Civil Engineers 2011 Journal of materials in civil engineering Vol.23 No.4
<P> Constitutive equations for asphalt binders and mixtures are important for predicting pavement performance, characterizing their flow behaviors, and establishing databases. To choose a proper constitutive equation, material characteristics such as single-phase, multiphase, viscous, or viscoelastic fluid must be identified because each phenomena shows its unique equation. Past literature treated rheological behaviors of asphalt binders as a homogeneous single-phase fluid, and asphalt binders were classified differently from those of asphalt concrete mixtures. These generalizations are not always true. This paper presents a classification of material phases and definition of yield stress that are introduced for the first time on a scientific basis. In this classification, constitutive equations for certain modified asphalt binders holding yield stress can be identical to those of asphalt concrete mixtures, when both belong to multiphase fluids. Also, a unique constitutive equation for the linear viscoelastic fluids is proposed to illustrate differentiation from the one of viscous fluids. All constitutive equations suggested here are used in regression analysis of the measured data and their efficacy is proven in excellent curve fittings. Finally, temperature and aggregate concentration effects are added to propose the most versatile multiphase linear viscoelastic constitutive equation. </P>
Inhalation Lung Injury Associated with Humidifier Disinfectants in Adults
Huh, Jin-Won,Hong, Sang-Bum,Do, Kyung-Hyun,Koo, Hyun Jung,Jang, Se Jin,Lee, Moo-Song,Paek, Domyung,Park, Dong-Uk,Lim, Chae-Man,Koh, Younsuck The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.12
<P>We recently established a novel disease entity presented as progressive respiratory failure associated with the inhalation of humidifier disinfectants. In April 2011, we encountered a series of peripartum patients with complaints of respiratory distress of unknown etiology, which was an uncommon phenomenon. Accordingly, we created a multidisciplinary team comprising intensivists, radiologists, pathologists, epidemiologists, and the Korea Centers for Disease Control and Prevention (KCDC). Further, we defined the disease entity and performed a case-control study, epidemiologic investigation, and animal study to determine the etiology. The study findings indicated that the lung injury outbreak was related to the inhalation of humidifier disinfectants and showed that household chemical inhalation can cause severe respiratory failure. Following the withdrawal of humidifier disinfectants from the Korean market in 2012, no such cases were reported. This tragic event is a warning that appropriate safety regulations and monitoring for potential toxic household chemicals are critical to protect public health.</P>