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- 저자 : Discher, Dennis E. (검색결과 2 건)
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Michael Discher,김형택,이정일 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.2
Investigations of retrospective dosimetry have shown that components of mobile phones are suitable asemergency dosimeters in case of radiological incidents. For physical dosimetry, components can be readout using optically stimulated luminescence (OSL), thermoluminescence (TL) and phototransferredthermoluminescence (PTTL) methods to determine the absorbed dose. This paper deals with a feasibilitystudy of display glass from modern mobile phones that are measured by thermally assisted (Ta) opticallystimulated luminescence. Violet (VSL, 405 nm) and infrared (IRSL, 850 nm) LEDs were used for opticalstimulation and two protocols (Ta-VSL and Ta-IRSL) were tested. The aim was to systematically investigate the luminescence properties, compare the results to blue stimulated Ta-BSL protocol (458 nm) andto develop a robust measurement protocol for the usage as an emergency dosimeter after an incidentwith ionizing radiation. First, the native signals were measured to calculate the zero dose signal. Next, the reproducibility anddose response of the luminescence signals were analyzed. Finally, the signal stability was tested after thestorage of irradiated samples at room temperature. In general, the developed Ta-IRSL and Ta-VSL protocols indicate usability, however, further research is needed to test the potential of a new protocol forphysical retrospective dosimetry
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Bio-inspired, bioengineered and biomimetic drug delivery carriers
Yoo, Jin-Wook,Irvine, Darrell J.,Discher, Dennis E.,Mitragotri, Samir Nature Publishing Group, a division of Macmillan P 2011 Nature reviews. Drug discovery Vol.10 No.7
Synthetic carriers such as polymer and lipid particles often struggle to meet clinical expectations. Natural particulates ?? that range from pathogens to mammalian cells ?? are therefore worth examining in more depth, as they are highly optimized for their specific functions in vivo and possess features that are often desired in drug delivery carriers. With a better understanding of these biological systems, in conjunction with the availability of advanced biotechnology tools that are useful for re-engineering the various natural systems, researchers have started to exploit natural particulates for multiple applications in the delivery of proteins, small interfering RNA and other therapeutic agents. Here, we review the natural drug delivery carriers that have provided the basis and inspiration for new drug delivery systems.
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