Preliminary Imaging Analysis for Enhanced Intestinal Uptake of Non-soluble Polystyrene Microspheres in the Presence of Oleic Acid using Rat Intestine

Tran, Huyen Thi Thanh,Tran, Phuong Ha Lien,Tran, Thao Truong-Dinh,Lee, Kyung-Ho,Lee, Beom-Jin The Korean Society of Pharmaceutical Sciences and 2009 Journal of Pharmaceutical Investigation Vol.39 No.3

In vitro intestinal uptake of non-soluble polystyrene microspheres (NPMS) was visualized with and without oleic acid using a fluorescence microscopy. Fluorescent polystyrene latex microspheres with 1${\mu}$m larger size were used as models for nonspecifically absorbed nonbiodegradable particulates. The NPMS could not penetrate the enterocytes but a few NPMS could be penetrated via Peyer's patches. When the oleic acid was mixed with NPMS, the transporting efficiency of NPMS through enterocytes as well as Peyer's patches was significantly enhanced. The modification of the intestinal membrane permeability and surface feature of the NPMS in the presence of oleic acid might be a clue to the transport of NSPM although the detailed mechanism is still under investigation.

Biodistribution and <i>in vivo</i> performance of fattigation-platform theranostic nanoparticles

Tran, Thao Truong-Dinh,Tran, Phuong Ha-Lien,Amin, Hardik H.,Lee, Beom-Jin Elsevier 2017 Materials science & engineering. C, Materials for Vol.79 No.-

<P><B>Abstract</B></P> <P>This study was aimed at characterizing superparamagnetic nanoparticles surface-functionalized with gelatin-oleic acid (GOAS-MNPs) and loaded with paclitaxel by assessing the pharmacokinetics and biodistribution of paclitaxel in tissues and the <I>in vivo</I> efficacy of antitumor activity after the administration of the drug. Initially, instrumental analysis was performed to examine the particle size distribution, surface charge, and morphology of the paclitaxel-loaded GOAS-MNPs. Furthermore, we evaluated their magnetic properties and performed T2-weighted magnetic resonance imaging (MRI) on cells. We intravenously administered Taxol® and paclitaxel-loaded GOAS-MNPs and compared the pharmacokinetics, biodistribution, and antitumor efficacies of the two formulations. Determination of the pharmacokinetics and the biodistribution of paclitaxel-loaded NPs showed that this formulation increased the systemic circulation time of paclitaxel and regulated its transport to tissues. The <I>in vivo</I> antitumor efficacy of the paclitaxel-loaded NPs was better than that of Taxol® at the same dose. Furthermore, the paclitaxel-loaded GOAS-MNPs were found to be effective as contrast agents for enhanced MRI in cancer cells. Thus, GOAS-MNPs could be an effective diagnostic system for cancer and for the delivery of paclitaxel with better therapeutic effects and a significant reduction in toxicity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Improving therapeutic efficacy and lower toxicity </LI> <LI> A significant inhibition of tumor growth </LI> <LI> Could be used as MRI contrast agents </LI> </UL> </P>

Fattigation-platform theranostic nanoparticles for cancer therapy

Tran, Thao Truong-Dinh,Tran, Phuong Ha-Lien,Yoon, Tae-Jong,Lee, Beom-Jin Elsevier 2017 Materials science & engineering. C, Materials for Vol.75 No.-

<P>A new conceptual nanoparticle consisting of a silica-coated iron oxide magnetic core and a fattigation-based biocompatible shell with oleic acid and hydrophilic protein (gelatin). The prepared particle can be a useful theranostics platform material for diagnostic imaging and as a drug delivery system. Oleic acid and gelatin were conjugated on the silica-coated magnetic nanoparticle surface to provide three primary functionalities: 1) enhancing biocompatibility and solubility in aqueous solution and providing the ability to incorporate hydrophobic chemical drugs into the shell for delivery, 2) improving treatment-response magnetic monitoring as a diagnostic agent with low nanotoxicity, and 3) increasing anticancer efficacy owing to the controlled release of the incorporated drug in cells and in an animal model. We prepared magnetic-silica nanoparticles with super paramagnetic properties, which are utilized as a T-2-weighted magnetic resonance imaging agent. After formation of an oleic acid-gelatin shell, the prepared materials exhibited high loading capacity for a hydrophobic anticancer drug (paclitaxel). Our particle platform system exhibited higher therapeutic efficacy and lower toxicological effects in vitro and in an in vivo cancer model than a clinically available chemo-drug (Taxol (R)). Our findings strongly suggest that this nanoparticle system can serve as a platform for cancer therapy by the incorporation of chemical drugs. (C) 2017 Elsevier B.V. All rights reserved.</P>

Promising Iron Oxide-based Magnetic Nanoparticles in Biomedical Engineering

Phuong Ha-Lien Tran,Thao Truong-Dinh Tran,Toi Van Vo,이범진 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.12

For the past few decades biomedical engineering has imprinted its significant impact on the map of science through its wide applications on many other fields. An important example obviously proving this fact is the versatile application of magnetic nanoparticles in theranostics. Due to preferable properties such as biocompatibility, non-toxicity compared to other metal derivations, iron oxide-based magnetic nanoparticles was chosen to be addressed in this review. Aim of this review is to give the readers a whole working window of these magnetic nanoparticles in the current context of science. Thus, preparation of magnetic iron oxide nanoparticles with the so-far techniques, methods of characterizing the nanoparticles as well as their most recent biomedical applications will be stated.

Roles of MgO Release from Polyethylene Glycol 6000-based Solid Dispersions on Microenvironmental pH, Enhanced Dissolution and Reduced Gastrointestinal Damage of Telmisartan

Phuong Ha Lien Tran,이범진,Thao Truong-Dinh Tran,Seung Aeon Lee,Vo Hong Nho,Sang-Cheol Chi 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.5

The roles of magnesium oxide (MgO) release from solid dispersions (SDs) in simulated gastric fluid (SGF), simulated intestinal fluid (SIF) and water were investigated to elucidate the enhanced dissolution and reduced intestinal damages of telmisartan as a model drug. The polyethylene glycol 6000 (PEG 6000) was used to prepare the SDs. Three SDs were prepared: SD1(PEG, MgO, TEL), SD2 (PEG 6000, TEL), SD3 (MgO, TEL). The physical mixture (PM) consisting of SD2 and MgO was also prepared. A binary SD without MgO (SD2) was also prepared for comparison in microenvironmental pH (pH_M) modulation. The faster MgO released, the less control of pH_M and the less enhanced dissolution of TEL were in consequences. SD3 increased dissolution in SIF and water (about 67%). Interestingly, ternary SD1 showed almost complete dissolution in all three media but dissolution of PM was the lowest due to the fast release of MgO and poor modulation of pHM. MgO did not change the drug crystallinity but did have a strong molecular interaction with the drug. Additionally, the SD3-bearing tablet quickly increased pHM but then gradually decreased due to faster release of MgO while the SD1-bearing tablet gradually increased pH_M at all fractional dimensions of the tablet by the MgO slowly released. The pH_M of PM-bearing tablets was not varied as a function of time. Thus, the MgObearing SD1 also minimized gastrointestinal tissue damage caused by the model drug.

Effects of Solvents and Crystallization Conditions on the Polymorphic Behaviors and Dissolution Rates of Valsartan

Thao Truong-Dinh Tran,이범진,Phuong Ha-Lien Tran,박준범 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7

For the quality evaluation of raw materials, the influence of various types of solvents on the polymorphic crystallization behaviors and dissolution rates of two sources of valsartan (VAL) from China and India was investigated. Samples were prepared by recrystallization from water or organic solvents, such as acetonitrile, acetone and ethanol, using methods with and without heating. Recrystallization behaviors were characterized by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). Scanning electron microscopy (SEM) was also used to observe the morphology of samples. The dissolution rate of recrystallized samples in water was evaluated and compared to the original VAL sample. There were significant differences in morphology, crystal structure and dissolution rate among the samples recrystallized using organic solvents. VAL was transformed into another polymorphic form by the solvents and recrystallization conditions. These physical properties of VAL also differed between the two sources of VAL. Thus, the physicochemical differences of raw materials should be carefully considered in early dosage formulation approaches.

Preliminary Imaging Analysis for Enhanced Intestinal Uptake of Non-soluble Polystyrene Microspheres in the Presence of Oleic Acid using Rat Intestine

Huyen Thi Thanh Tran,Phuong Ha Lien Tran,Thao Truong Dinh Tran,Kyung Ho Lee,Beom Jin Lee 韓國藥劑學會 2009 Journal of Pharmaceutical Investigation Vol.39 No.3

Understanding the COVID-19 Infodemic: Analyzing User-Generated Online Information During a COVID-19 Outbreak in Vietnam

Ha-Linh Quach,Thai Quang Pham,Ngoc-Anh Hoang,Dinh Cong Phung,Viet-Cuong Nguyen,Son Hong Le,Thanh Cong Le,Dang Hai Le,Anh Duc Dang,Duong Nhu Tran,Nghia Duy Ngu,Florian Vogt,Cong-Khanh Nguyen 대한의료정보학회 2022 Healthcare Informatics Research Vol.28 No.4

Objectives: Online misinformation has reached unprecedented levels during the coronavirus disease 2019 (COVID-19) pandemic. This study analyzed the magnitude and sentiment dynamics of misinformation and unverified information about public health interventions during a COVID-19 outbreak in Da Nang, Vietnam, between July and September 2020. Methods: We analyzed user-generated online information about five public health interventions during the Da Nang outbreak. We compared the volume, source, sentiment polarity, and engagements of online posts before, during, and after the outbreak using negative binomial and logistic regression, and assessed the content validity of the 500 most influential posts. Results: Most of the 54,528 online posts included were generated during the outbreak (n = 46,035; 84.42%) and by online newspapers (n = 32,034; 58.75%). Among the 500 most influential posts, 316 (63.20%) contained genuine information, 10 (2.00%) contained misinformation, 152 (30.40%) were non-factual opinions, and 22 (4.40%) contained unverifiable information. All misinformation posts were made during the outbreak, mostly on social media, and were predominantly negative. Higher levels of engagement were observed for information that was unverifiable (incidence relative risk [IRR] = 2.83; 95% confidence interval [CI], 1.33–0.62), posted during the outbreak (before: IRR = 0.15; 95% CI, 0.07–0.35; after: IRR = 0.46; 95% CI, 0.34-0.63), and with negative sentiment (IRR = 1.84; 95% CI, 1.23–2.75). Negatively toned posts were more likely to be misinformation (odds ratio [OR] = 9.59; 95% CI, 1.20–76.70) or unverified (OR = 5.03; 95% CI, 1.66–15.24). Conclusions: Misinformation and unverified information during the outbreak showed clustering, with social media being particularly affected. This indepth assessment demonstrates the value of analyzing online “infodemics” to inform public health responses.

Some Measures to Prevent and Control Sacbrood Disease on Honey Bee Apis cerana in Viet Nam

Tran Van Toan,Phung Huu Chinh,Dinh Quyet Tam,Myeong Lyeol Lee,Ha Sik Sim,Hye Kyung Kim,Gyu Ho Byuon,Yong Soo Choi 한국양봉학회 2014 韓國養蜂學會誌 Vol.29 No.1

Apis cerana is one of the native honey bee species in Viet Nam. This Asian honey bee species has been domesticated, kept and honey-harvested for a long time by farmers and professional beekeepers. However, the Asian honey bee Apis cerana is sometime infected by different diseases such as European foulbrood, Nosema and Sacbrood. Of which the Sacbrood disease is considered to be the most common and cause seriously economic losses to the beekeepers in Viet Nam. In the past years, remedial actions including medicaments extracted from plants, biological methods and bee breeding have been effectively applied by Vietnamese beekeepers. This paper reviews the work on some measures of prevention and control Sacbrood disease on Apis cerana.

Factors Affecting Logistics Capabilities for Logistics Service Providers: A Case Study in Vietnam

Dinh Dao DANG,Dieu Linh HA,Van Bao TRAN,Van Tuan NGUYEN,Thi Lien Huong NGUYEN,Thuy Hong DANG,Thi Thai Ha LE 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.5

This study aimed to investigate the factors affecting Logistics capabilities for Logistics Service Providers in Vietnam. Researchers inherited and developed based on previous research to focus on analyzing and evaluating dynamics, measuring Logistics capabilities, and the factors affecting Logistics capabilities for Logistics Service Providers. The logistics capabilities Model is used based on three factors: customer demand management capability, innovation capability, and information management capability. The empirical analysis used data from the survey data of l90 managers of Logistics Service Providers in Hai Phong, Ho Chi Minh City, Da Nang, Hue, Hanoi with reliable tools (SPSS 26.0 software). The data were analyzed by frequencies, percentages, means, Pearson’s Linear Correlation Coefficient, exploratory factor analysis, and multi-linear regression model based on the survey data. The research results identified the following factors affecting Logistics capabilities for Logistics Service Providers: innovation capability has the strongest impact on Logistics capabilities; customer demand management capability has the following strong effects on Logistics capabilities; and finally, information management capability that affects Logistics capabilities. There is also a positive relationship between all factors and Logistics capabilities. Several recommendations are further suggested to enhance to improve Logistics capabilities for Logistics Service Providers in Vietnam.