http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국인 말단비대증 환자에서 SR-Lanreotide 의 치료 효과
김덕윤,최영길,김영설,김선우,양인명,우정택,김성운,서광식,오승준,임을순,김상화,김진우 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.3
Background: Previous studies have shown that somatostatin analogues such as octreotide are effective in suppressing GH and IGF-I levels in acromegaly. The recent availability of slow release lanreotide could avoid the inconveniences associated with either repeated subcutaneous injections or continuous infusions. We investigated the effects of the SR-lanreotide on clinical, biochemical and safety responses in five patients with acromegaly. And we investigated whether the response of the GH level to acute adrninistration of octreotide predicts the response after 12 weeks of treatment with the SR-lanreotide and whether the identification of gsp oncogene could be used as a therapeutic and prognostic clue in treatment with the SR-lanreotide. Methods: We studied the effects of SR-lanreotide 30 mg administered intramuscularly biweekly for 12 weeks in five Korean acromegalic patients. Subjective improvements in the clinical symptoms of acromegaly and adverse reactions were recorded. During SR-lanreotide treatment, serum GH, IGF-I and IGFBP-3 concentrations were evaluated just before the next injection of the SR-lanreotide. Before the start of SR-lanreotide therapy the sensitivity of GH secretion to the octreotide was tested by measuring the effect of the acute response to 0.1 mg intravenously on plasma GH levels followed until 6 hours after administration of octreotide. Direct polymerase chain reaction sequencing of the gsp oncogene were performed. We compared the responses to SR-lanreotide in patients harboring gsp-positive and gsp-negative somatotroph adenomas. Results: The treatment with SR-lanreotide for 12 weeks could suppress the GH level by more than 50% in four of five patients and normalize the IGF-I in two patients. No correlation was found between the GH level and IGF-I level at the end of the study. The IGFBP-3 level correlated with the IGF-I level in three of five patients. Although the initial GH response to octreotide tended to correlate with the IGF-I response after SR-lanreotide treatment, the results were statistically insignificant. The patients with gsp-positive tumor tended to show a better response to SR-lanreotide. During treatment, there was a reduction in the percentage of patients complaining of joint pain, fatigue, digital paresthesia, and hyperhydrosis. Changes in soft tissue swelling were documented by decreases in finger circumference. The common adverse events were abdominal discomfort, loose stool, and diarrhea. These events were decreased progressively. No patients discontinued the treatment of SR-lanreotide due to adverse events. Conclusion: This study showed that SR-lanreotide is effective in controlling acromegalic symptoms as well as GH and IGF-I hypersecretion. This treatment was well tolerated and more convenient for the patients. Further studies are required for clinical outcome of long-term SR-lanreotide treatment and cost-effective analysis (J Kor Soc Endocrinol 14:458-471, 1999).
Evaluation of the Rib Seriation Using Analysis of Quantitative Methods in Koreans
Deog-Im Kim(김덕임),Seung-Ho Han(한승호),Yi-Suk Kim(김이석),Dae-Kyoon Park(박대균),U-Young Lee(이우영),In-Hyuk Chung(정인혁) 대한체질인류학회 2009 해부·생물인류학 (Anat Biol Anthropol) Vol.22 No.2
한국인 유골을 이용한 신원확인에서 갈비뼈순서맞추기는 시도된 적이 없었다. 정확한 갈비뼈순서맞추기는 갈비뼈 순서의 유추와 사망당시의 나이추정에 중요한 역할을 한다. 이 연구의 목적은 기존에 증명된 양적 방법을 이용하여 한국인 갈비뼈의 정확한 순서를 추정할 수 있는지 평가하는 것에 있다. 54명의 완벽한 갈비뼈들을 이용하여 3개의 항목을 계측하였다. 계측항목은 갈비뼈 결절의 관절면에서 갈비뼈각까지의 거리(AFTAL), 갈비뼈머리에서 관절면까지의 거리(HAFL), 그리고 위갈비가로능선높이(SCTCH)이다. AFTAL와 SCTCH 항목이 갈비뼈순서를 추정하는 데 있어 HAFL 항목보다 더 유용하였으며 AFTAL 항목은 성별판별을 위한 판별식들 중 정확도가 높으며 가장 간단한 방정식을 만들 수 있었다. AFTAL 항목을 이용한 갈비뼈순서의 유추는 정확한 순서를 유추할 확률은 79%이었으며 갈비뼈순서 유추의 오류범위는 ±4이었다. 유럽인을 대상으로 한 다른 연구와 비교하면 한국인을 대상으로 한 연구결과가 더 정확도가 높았다. 이 연구에 사용된 넷째 갈비뼈의 정확한 유추는 AFTAL 항목과 AFTAL과 SCTCH 항목을 같이 사용하여 실시한 방법이 94%로 가장 높 았다. AFTAL 항목이 갈비뼈순서를 유추하는 데 있어 가장 정확도가 높았으며 SCTCH 항목의 경우 이 항목만을 이용한 경우보다 AFTAL 항목을 같이 사용하는 경우가 정확도가 높았다. 이러한 높은 정확도와 유추력은 한국인의 갈비뼈순서맞추기에 양적 방법이 유용하다는 것을 알 수 있다. Rib seriation has not been used to identify individual human skeletal remains in Koreans. Accurate rib seriation is important for determining rib number and for establishing an individual’s age at death. The aim of this study was to use a previously published quantitative method to correctly predict rib sequencing in Koreans. We used complete rib sets of 54 individuals and measured three variables: AFTAL (articular facet of the tubercle-toangle length), HAFL (head-to-articular facet length), and SCTCH (superior costo-transverse crest height). AFTAL and SCTCH were more useful than HAFL for predicting rib seriation, and AFTAL produced the simplest equation for determining sex. In the ranking, the cumulative percentage of AFTAL was 79% with an error of 0, and the range of seriation error was ±4. Compared to other studies using European measures, AFTAL showed greater accuracy of rib seriation in this study of Korean ribs. In fact, both AFTAL and AFTAL with SCTCH accurately predicted rib 4 in 94% of cases. AFTAL was the most accurate, and use of both SCTCH and AFTAL yielded better results than either alone. Thus, the high accuracy and predictive ability showed that this method is useful for measuring rib seriation in Koreans.
Topography of human ankle joint: focused on posterior tibial artery and tibial nerve
Deog-Im Kim,Yi-Suk Kim,Seung-Ho Han 대한해부학회 2015 Anatomy & Cell Biology Vol.48 No.2
Most of foot pain occurs by the entrapment of the tibial nerve and its branches. Some studies have reported the location of the tibial nerve; however, textbooks and researches have not described the posterior tibial artery and the relationship between the tibal nerve and the posterior tibial artery in detail. The purpose of this study was to analyze the location of neurovascular structures and bifurcations of the nerve and artery in the ankle region based on the anatomical landmarks. Ninety feet of embalmed human cadavers were examined. All measurements were evaluated based on a reference line. Neurovascular structures were classified based on the relationship between the tibial nerve and the posterior tibial artery. The bifurcation of arteries and nerves were expressed by X- and Y-coordinates. Based on the reference line, 9 measurements were examined. The most common type I (55.6%), was the posterior tibial artery located medial to the tibial nerve. Neurovascular structures were located less than 50% of the distance between M and C from M at the reference line. The bifurcation of the posterior tibial artery was 41% in X-coordinate, - 38% in Y-coordinate, and that of the tibial nerve was 48%, and - 10%, respectively. Thirteen measurements and classification showed statistically significant differences between both sexes (P