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The statistical optimization of bacterial cellulose production via semi-continuous operation mode
Ali O¨ zhan Aytekin,Deniz Dilan Demirbag,Tug˘c¸e Bayrakdar 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.37 No.-
Bacterial cellulose (BC) is highly pure and has a higher crystallinity and molecular weight than plantcellulose. Therefore, BC can be used in many different areas such as biotechnology, pharmaceutical,cosmetics. Because of the price of BC, the productivity of BC is an important parameter for industrial scaleapplications. In this study, BC was produced in static culture using a semi-continuous operation mode;the conditions were optimized using response surface methodology (RSM). The collected BC wascharacterized by Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM),and tensile strength. Optimization parameters were selected as glucose concentration, surface area/volume ratio, surface area and incubation day intervals. The optimum values for incubation dayintervals, volume changing ratios, glucose concentrations and surface area/volume ratios were 7 days,66%, 50 g/L and 1.22 cm 1, respectively. BC productivity reached 0.284 g/L/day under optimalconditions, while the model equation proposed 0.289 g/L/day. RSM is essential for determining theoptimum values of parameters for BC production compared with the one-variable-at-a-time method. The semi-continuous operation mode is alternative and a good candidate for the industrial scaleproduction of BC.