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Sharma, Deepti,Lee, Jongmin,Shin, Heungjoo Elsevier Applied Science 2018 Biosensors & bioelectronics Vol. No.
<P><B>Abstract</B></P> <P>We developed an electrochemical redox cycling-based immunosensor using a 3D carbon system consisting of a suspended mesh and substrate-bound interdigitated array (IDA) nanoelectrodes. The carbon structures were fabricated using a simple, cost-effective, and reproducible microfabrication technology known as carbon microelectromechanical systems (C-MEMS). We demonstrated that the 3D sub-micrometer-sized mesh architecture and selective modification of the suspended mesh facilitated the efficient production of large quantities of electrochemical redox species. The electrochemically active surfaces and small size of IDA nanoelectrodes with a 1:1 aspect ratio exhibited high signal amplification resulting from efficient redox cycling of electrochemical species (PAP/PQI) by a factor of ~25. The proposed selective surface modification scheme facilitated efficient redox cycling and exhibited a linear detection range of 0.001–100 ng/mL for cardiac myoglobin (cMyo). The specific detection of cMyo was also achieved in the presence of other interfering species. Moreover, the proposed 3D carbon system-based immunosensor successfully detected as low as ~0.4 pg/mL cMyo in phosphate-buffered saline and human serum.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An electrochemical redox cycling-based immunosensor using a 3D carbon system was developed. </LI> <LI> The 3D carbon systems consisted of a suspended mesh and substrate-bound interdigitated array (IDA) nanoelectrodes. </LI> <LI> A small gap between the sandwich immunoassay on the mesh and IDA nanoelectrodes ensured effective supply of redox species. </LI> <LI> Small size of the substrate-bound IDA nanoelectrodes resulted in efficient redox cycling. </LI> <LI> A detection limit of 0.43 pg/mL and linear range of 0.001–100 ng/mL for cardiac myoglobin detection were achieved. </LI> </UL> </P>
Determination of levels of nitric oxide in smoker and nonsmoker patients with chronic periodontitis
Deepti Wadhwa,Afshan Bey,Mukesh Hasija,Shagufta Moin,Arun Kumar,Shazia Aman,Vivek Kumar Sharma 대한치주과학회 2013 Journal of Periodontal & Implant Science Vol.43 No.5
Purpose: Cigarette smoking is a major risk factor in periodontal diseases. The pathogenesis of periodontal diseases may be affected by alterations of the inflammatory response by smoke. Nitric oxide (NO) is a gaseous, colorless, highly reactive, shortlived free radical with a pivotal role in the regulation of various physiological and pathological mechanisms in the body. It is important in host defense and homeostasis, on the one hand, whereas, on the other hand, it modulates the inflammatory response in periodontitis, leading to harmful effects. The aim of this study was to assess the levels of NO in both the serum and saliva of smokers and nonsmokers having chronic periodontitis and to compare them with periodontally healthy controls. Methods: Sixty subjects participated in the study and were divided into three groups: group I, healthy nonsmoking subjects;group II, nonsmoking patients with chronic periodontitis; group III, smoking patients with chronic periodontitis. Each group consisted of twenty subjects. The biochemical estimation of NO in the collected serum and in the saliva was performed using the Griess colorimetric reaction. Results: The results showed that the mean value of the salivary and serum NO was greater in group II than in group I, and also greater in group III than in group II. Conclusions: NO appears to play an important and rather complex role in the immuno-inflammatory process and in the remodeling and maintenance of osseous structures. It is therefore logical that modulation of this mediator has potential for the treatment of a number of inflammatory conditions including periodontal disease. Purpose: Cigarette smoking is a major risk factor in periodontal diseases. The pathogenesis of periodontal diseases may be affected by alterations of the inflammatory response by smoke. Nitric oxide (NO) is a gaseous, colorless, highly reactive, shortlived free radical with a pivotal role in the regulation of various physiological and pathological mechanisms in the body. It is important in host defense and homeostasis, on the one hand, whereas, on the other hand, it modulates the inflammatory response in periodontitis, leading to harmful effects. The aim of this study was to assess the levels of NO in both the serum and saliva of smokers and nonsmokers having chronic periodontitis and to compare them with periodontally healthy controls. Methods: Sixty subjects participated in the study and were divided into three groups: group I, healthy nonsmoking subjects;group II, nonsmoking patients with chronic periodontitis; group III, smoking patients with chronic periodontitis. Each group consisted of twenty subjects. The biochemical estimation of NO in the collected serum and in the saliva was performed using the Griess colorimetric reaction. Results: The results showed that the mean value of the salivary and serum NO was greater in group II than in group I, and also greater in group III than in group II. Conclusions: NO appears to play an important and rather complex role in the immuno-inflammatory process and in the remodeling and maintenance of osseous structures. It is therefore logical that modulation of this mediator has potential for the treatment of a number of inflammatory conditions including periodontal disease.
Determination of levels of nitric oxide in smoker and nonsmoker patients with chronic periodontitis
Wadhwa, Deepti,Bey, Afshan,Hasija, Mukesh,Moin, Shagufta,Kumar, Arun,Aman, Shazia,Sharma, Vivek Kumar Korean Academy of Periodontology 2013 Journal of Periodontal & Implant Science Vol.43 No.5
Purpose: Cigarette smoking is a major risk factor in periodontal diseases. The pathogenesis of periodontal diseases may be affected by alterations of the inflammatory response by smoke. Nitric oxide (NO) is a gaseous, colorless, highly reactive, short-lived free radical with a pivotal role in the regulation of various physiological and pathological mechanisms in the body. It is important in host defense and homeostasis, on the one hand, whereas, on the other hand, it modulates the inflammatory response in periodontitis, leading to harmful effects. The aim of this study was to assess the levels of NO in both the serum and saliva of smokers and nonsmokers having chronic periodontitis and to compare them with periodontally healthy controls. Methods: Sixty subjects participated in the study and were divided into three groups: group I, healthy nonsmoking subjects; group II, nonsmoking patients with chronic periodontitis; group III, smoking patients with chronic periodontitis. Each group consisted of twenty subjects. The biochemical estimation of NO in the collected serum and in the saliva was performed using the Griess colorimetric reaction. Results: The results showed that the mean value of the salivary and serum NO was greater in group II than in group I, and also greater in group III than in group II. Conclusions: NO appears to play an important and rather complex role in the immuno-inflammatory process and in the remodeling and maintenance of osseous structures. It is therefore logical that modulation of this mediator has potential for the treatment of a number of inflammatory conditions including periodontal disease.
Lee, Jongmin,Sharma, Deepti,Lim, Yeongjin,Shin, Heungjoo Elsevier 2018 Sensors and actuators. B, Chemical Vol.267 No.-
<P><B>Abstract</B></P> <P>Electrochemical sensing based on redox cycling is widely used as the detection scheme in microfluidic devices because of its simple configuration and relatively high sensitivity. However, integrating dual microelectrodes to enable redox cycling in the microchannel requires complex and cumbersome alignment procedures. In this paper, we present a simple alignment-less fabrication method for microchannel-integrated sandwich electrodes consisting of a suspended carbon mesh electrode and a substrate-bound planar electrode. Because the long carbon posts that support the suspended mesh serve as microchannel side walls, simple oxygen-plasma-assisted bonding of a flat polydimethylsiloxane plate can complete channel integration. Despite the cavity of the suspended mesh, the proposed electrochemical sensing platform exhibits a good redox cycling efficiency that is comparable to twin-plate electrodes because of the small cavity size. We also demonstrate the advantages of channel integration in redox cycling with respect to the sensitivity and selectivity in dopamine sensing.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Alignment-less fabrication of microchannel-integrated carbon sandwich electrodes. </LI> <LI> Sandwich electrodes consisted of a suspended mesh and a substrate-bound electrode. </LI> <LI> Microchannel-integrated sandwich electrodes exhibited high redox cycling efficiency. </LI> <LI> Sensitivity enhancement due to confined mass transfer in a microchannel. </LI> <LI> Selective detection of reversible target analytes was enabled in a microchannel. </LI> </UL> </P>