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Tinnitus and the Triple Network Model: A Perspective
Dirk De Ridder,송재진,Sven Vanneste,Divya Adhia 대한이비인후과학회 2022 Clinical and Experimental Otorhinolaryngology Vol.15 No.3
Tinnitus is defined as the conscious awareness of a sound without an identifiable external sound source, and tinnitus disorder as tinnitus with associated suffering. Chronic tinnitus has been anatomically and phenomenologically separated into three pathways: a lateral “sound” pathway, a medial “suffering” pathway, and a descending noise-canceling pathway. Here, the triple network model is proposed as a unifying framework common to neuropsychiatric disorders. It proposes that abnormal interactions among three cardinal networks—the self-representational default mode network, the behavioral relevance-encoding salience network and the goal-oriented central executive network—underlie brain disorders. Tinnitus commonly leads to negative cognitive, emotional, and autonomic responses, phenomenologically expressed as tinnitus-related suffering, processed by the medial pathway. This anatomically overlaps with the salience network, encoding the behavioral relevance of the sound stimulus. Chronic tinnitus can also become associated with the self-representing default mode network and becomes an intrinsic part of the self-percept. This is likely an energy-saving evolutionary adaptation, by detaching tinnitus from sympathetic energy-consuming activity. Eventually, this can lead to functional disability by interfering with the central executive network. In conclusion, these three pathways can be extended to a triple network model explaining all tinnitus-associated comorbidities. This model paves the way for the development of individualized treatment modalities.
Parameter space exploration for the probabilistic damage stability method for dry cargo ships
Milatz Bas,de Winter Roy,van de Ridder Jelle D.J.,van Engeland Martijn,Mauro Francesco,Kana Austin A. 대한조선학회 2023 International Journal of Naval Architecture and Oc Vol.15 No.-
The prediction of the statutory attained subdivision index is a challenging issue for the initial design of ships due to the design freedom offered by a probabilistic damage stability assessment. To this end, optimisation techniques integrated with a parametric model of the internal layout may generate a preliminary subdivision design, fulfilling damage stability regulations and cargo volume requirements. The present study explores using a multiobjective constrained optimisation algorithm coupled with a parametric model of a single hold cargo vessel, first investigating two design goal alternatives and secondly performing a global sensitivity analysis on the design variables for the most promising solution. The adoption, in parallel, of state-of-the-art practices shows the validity of the obtained solutions and the time benefits for designers. Nonetheless, the non-linear nature of probabilistic damage stability does not allow for clearly identifying the most impactful parameters on the attained survivability index.
Song, Jae-Jin,De Ridder, Dirk,Weisz, Nathan,Schlee, Winfried,Van de Heyning, Paul,Vanneste, Sven Springer Science + Business Media 2014 BRAIN STRUCTURE AND FUNCTION Vol.219 No.3
<P>Although hyperacusis, a hyperresponsiveness to non-noxious auditory stimuli, is a sound-evoked symptom, possible resting-state pathologic oscillations in hyperacusis brain have never been explored. By comparing 17 tinnitus participants with hyperacusis (T+H+) and 17 without hyperacusis (T+H-), we aimed to explore characteristic resting-state cortical activity of hyperacusis. The T+H+ and T+H- groups, strictly matched for all tinnitus sound characteristics to exclude tinnitus-related cortical changes, were compared using resting-state electroencephalography source-localized activity complemented by functional connectivity analyses. Correlation analysis revealed that hyperacusis questionnaire score was positively correlated with the orbitofrontal cortex (OFC) beta power, the right auditory cortex (AC) alpha1 power, and the dorsal anterior cingulate cortex (dACC) beta1 power. Compared to the T+H- group, the T+H+ group demonstrated increased beta power in the dACC and OFC, and increased alpha power in the right AC. Region of interest analyses including 17 normal controls further confirmed that these differences originated solely from relatively increased power of the T+H+ group, not from a relative power decrease of the T+H- group. Also, the T+H+ group showed increased connectivity between the OFC/dACC and the AC as compared to the T+H- group. The beta power increase in the OFC/dACC may indicate increased resting-state vigilance in tinnitus patients with hyperacusis. In addition, increased alpha power in the AC may reflect an adaptive top-down inhibition against sound stimuli probably mediated by the increased beta power of the OFC. The OFC/dACC, also frequently found to be activated in analogous diseases such as allodynia/hyperalgesia, may compose a hyperresponsiveness network.</P>
Song, Jae-Jin,An, Gwang Seok,Choi, Inyong,De Ridder, Dirk,Kim, So Young,Choi, Hyun Seok,Park, Joo Hyun,Choi, Byung Yoon,Koo, Ja-Won,Lee, Kyogu Lippincott Williams Wilkins 2016 Otology & Neurotology Vol.37 No.6
<P>Objective: Although frequently classified as 'objective tinnitus,' in most cases vascular pulsatile tinnitus (VPT) is not equal to objective tinnitus because it is not easy to objectively document VPT. The present study was conducted to develop a novel transcanal sound recording and spectro-temporal analysis method for the objective and differential diagnosis of VPT. Study Design: A case series with a control group. Setting: Tertiary referral center. Patients: Six VPT subjects with radiological abnormalities and six normal controls. Interventions and Main Outcome Measure: The method was tested based on recordings obtained from the ipsilateral external auditory canal (EAC) using an insert microphone with the subject's head in four different positions. The recorded signals were first analyzed in the time domain, and short-time Fourier transform was performed to analyze the data in the time-frequency domain. Results: From the temporal analysis, the ear canal signals recorded from the VPT subjects exhibited large peak amplitudes and periodic structures, whereas the signals recorded from the control subjects had smaller peak amplitudes and weaker periodicity. From the STA represented by two-dimensional spectrograms and three-dimensional waterfall diagrams, all of the VPT subjects demonstrated pulse-synchronous acoustic characteristics that were representative of their respective presumptive vascular pathologies, whereas the control subjects did not display such characteristics. Conclusion: The present diagnostic approach may provide additional information regarding the origins of VPT cases as well as an efficient and objective diagnostic method. Furthermore, this approach may aid in the determination of appropriate imaging modalities, treatment planning, and evaluation of treatment outcomes.</P>
Lee, S.Y.,Nam, D.W.,Koo, J.W.,De Ridder, D.,Vanneste, S.,Song, J.J. Elsevier/North-Holland,Biomedical Press 2017 Hearing research Vol.354 No.-
<P>Recent studies have adopted the Bayesian brain model to explain the generation of tinnitus in subjects with auditory deafferentation. That is, as the human brain works in a Bayesian manner to reduce environmental uncertainty, missing auditory information due to hearing loss may cause auditory phantom percepts, i.e., tinnitus. This type of deafferentation-induced auditory phantom percept should be preceded by auditory experience because the fill-in phenomenon, namely tinnitus, is based upon auditory prediction and the resultant prediction error. For example, a recent animal study observed the absence of tinnitus in cats with congenital single-sided deafness (SSD; Eggermont and Kral, Hear Res 2016). However, no human studies have investigated the presence and characteristics of tinnitus in subjects with congenital SSD. Thus, the present study sought to reveal differences in the generation of tinnitus between subjects with congenital SSD and those with acquired SSD to evaluate the replicability of previous animal studies. This study enrolled 20 subjects with congenital SSD and 44 subjects with acquired SSD and examined the presence and characteristics of tinnitus in the groups. None of the 20 subjects with congenital SSD perceived tinnitus on the affected side, whereas 30 of 44 subjects with acquired SSD experienced tinnitus on the affected side. Additionally, there were significant positive correlations between tinnitus characteristics and the audiometric characteristics of the SSD. In accordance with the findings of the recent animal study, tinnitus was absent in subjects with congenital SSD, but relatively frequent in subjects with acquired SSD, which sbggests that the development of tinnitus should be preceded by auditory experience. In other words, subjects with profound congenital peripheral deafferentation do not develop auditory phantom percepts because no auditory predictions are available from the Bayesian brain. (C) 2017 Elsevier B.V. All rights reserved.</P>