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Miguel A. De la Cruz,Miguel A. Ares,Diana Rodríguez-Valverde,Alba Adriana Vallejo-Cardona,Mario Alberto Flores-Valdez,Iris Denisse Cota Núñez,Michel de Jesús Aceves-Sánchez,Jonahtan Lira-Chávez,Jacobo 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.6
Mycobacterium tuberculosis produces mycolic acids which are relevant for persistence, recalcitrance to antibiotics and defiance to host immunity. c-di-GMP is a second messenger involved in transition from planktonic cells to biofilms, whose levels are controlled by diguanylate cyclases (DGC) and phosphodiesterases (PDE). The transcriptional regulator dosR, is involved in response to low oxygen, a condition likely happening to a subset of cells within biofilms. Here, we found that in M. bovis BCG, expression of both BCG1416c and BCG1419c genes, which code for a DGC and a PDE, respectively, decreased in both stationary phase and during biofilm production. The kasA, kasB, and fas genes, which are involved in mycolic acid biosynthesis, were induced in biofilm cultures, as was dosR, therefore suggesting an inverse correlation in their expression compared with that of genes involved in c-di-GMP metabolism. The relative abundance within trehalose dimycolate (TDM) of α- mycolates decreased during biofilm maturation, with methoxy mycolates increasing over time, and keto species remaining practically stable. Moreover, addition of synthetic c-di-GMP to mid-log phase BCG cultures reduced methoxy mycolates, increased keto species and practically did not affect α-mycolates, showing a differential effect of c-di-GMP on keto- and methoxy-mycolic acid metabolism.
Miguel, Leandro Fleck Fadel,Miguel, Leticia Fleck Fadel,Riera, Jorge Daniel,Menezes, Ruy Carlos Ramos De Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.27 No.5
The damage detection process may appear difficult to be implemented for truss structures because not all degrees of freedom in the numerical model can be experimentally measured. In this context, the damage locating vector (DLV) method, introduced by Bernal (2002), is a useful approach because it is effective when operating with an arbitrary number of sensors, a truncated modal basis and multiple damage scenarios, while keeping the calculation in a low level. In addition, the present paper also evaluates the noise influence on the accuracy of the DLV method. In order to verify the DLV behavior under different damages intensities and, mainly, in presence of measurement noise, a parametric study had been carried out. Different excitations as well as damage scenarios are numerically tested in a continuous Warren truss structure subjected to five noise levels with a set of limited measurement sensors. Besides this, it is proposed another way to determine the damage locating vectors in the DLV procedure. The idea is to contribute with an alternative option to solve the problem with a more widespread algebraic method. The original formulation via singular value decomposition (SVD) is replaced by a common solution of an eigenvector-eigenvalue problem. The final results show that the DLV method, enhanced with the alternative solution proposed in this paper, was able to correctly locate the damaged bars, using an output-only system identification procedure, even considering small intensities of damage and moderate noise levels.
de la Parra, Miguel,Sanchez, Gerardo,Lopez, Jaime,Perez, Adrian,Naal, Norberto Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.6
Chondroblastomas are rare entities accounting for approximately 1% of all primary bone tumors. We describe a case of a 7-year-old girl with a giant chondroblastoma of the maxilla, treated with bilateral class III maxillectomy and reconstruction with a double-barreled and double skin paddle fibular free flap. We show evidence of an excellent aesthetic outcome at 6 months' follow up with no evidence of tumor recurrence.
Miguel de la Parra,Gerardo Sanchez,Jaime Lopez,Adrian Perez,Norberto Naal 대한성형외과학회 2013 Archives of Plastic Surgery Vol.40 No.6
Chondroblastomas are rare entities accounting for approximately 1% of all primary bone tumors. We describe a case of a 7-year-old girl with a giant chondroblastoma of the maxilla, treated with bilateral class III maxillectomy and reconstruction with a double-barreled and double skin paddle fibular free flap. We show evidence of an excellent aesthetic outcome at 6 months’ follow up with no evidence of tumor recurrence.
Eduardo de Paula Miranda,Cristiano Mendes Gomes,Fábio César Miranda Torricelli,José de Bessa Júnior,José Everton de Castro,Bruno Roberto da Silva Ferreira,Ariel Gustavo Scafuri,Homero Bruschini,Miguel 대한배뇨장애요실금학회 2014 International Neurourology Journal Vol.18 No.2
Purpose: Lower urinary tract symptoms are numerous, but the specific impact of each of these symptoms on the quality of life (QoL) has not been evaluated in community-dwelling men. An assessment of these symptoms and their effects on QoL was the focus of this study. Methods: We performed a cross-sectional study with 373 men aged >50 years from a community setting. Patients completed the International Prostate Symptom Score questionnaire, which includes questions on each of the specific urinary symptoms and a question addressing health-related QoL that are graded from 0 to 5. We used the Pearson correlation test to assess the impact of each symptom on QoL. Results: Nocturia (58.9%) was the most prevalent urinary symptom. The mean score was 0.9±1.4 for incomplete emptying, 1.0±1.5 for frequency, 0.9±1.3 for intermittency, 0.8±1.3 for urgency, 1.0±1.5 for weak stream, 0.5±1.0 for straining, and 2.0±1.6 for nocturia. Nocturia and frequency were the only symptoms associated with poorer QoL, with nocturia showing a stronger association. Conclusions: Nocturia affects 50% of community dwelling men aged >50 years, and is the lower urinary tract symptom with the greatest negative impact on QoL.
Numerical model of a planar jet wiping system for continuous strip lines
Celia Miguel-González,Manuel García-Díaz,Bruno Pereiras,Miguel Vigil,Alejandro Rodríguez de Castro 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.7
The present study focuses on the numerical modelling of gas-jet wiping process. Many processes involving liquids are necessary during steel manufacturing, such as cooling, lubrication or cleaning. Satisfactory processes for removing the liquid are critical for the quality of the product obtained as well as for avoiding a product rejection in strip lines such as tandem mills and tinning lines. One the most widespread drying technology used is based on planar air-knives or nozzle rows which wipe the liquid out from the steel strip by creating an aerodynamic barrier. The objective of this paper is to analyze the performance of a simple air knife based on an inclined planar jet that is commonly used in many commercial or in-house built devices. A CFD model developed by using commercial software ANSYS FLUENT® was built in order to evaluate the wiping system depending on the type of feeding: central and lateral.
Liver transplantation for hepatocellular carcinoma at Centro Médico Nacional 20 de Noviembre-México
Alberto DE JESUS-FLORES,Carlos FLOREZ-ZORRILLA,Ricardo CERON-CASTILLO,Carlos VAZQUEZ-SALINAS,Nadia ROMERO-BEYER,Aczel SANCHEZ-CEDILLO,Miguel CHARCO-CRUZ 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-
Hidalgo-Garcia, Cesar,Tricas-Moreno, Jose Miguel,Lucha-Lopez, Orosia,Estebanezde-Miguel, Elena,Bueno-Gracia, Elena,Malo-Urries, Miguel,Perez-Guillen, Silvia,Fanlo-Mazas, Pablo,Ruiz-de-Escudero, Alazne International Academy of Physical Therapy Research 2016 Journal of International Academy of Physical Ther Vol.7 No.1
The purpose of this study is to explore the effects of mobilization of C0-C1 and C7-T1 applied to asymptomatic individuals with reduced upper cervical rotation during the FRT. Design: parallel randomized controlled trial. 48 subjects(38.52 years${\pm}15.13$) with C1-C2 rotation hypomobility in TFR joined the study and were randomized into three groups(C0, C7, control group). FRT in both directions was measured before and after the intervention. C0 intervention consisted of a dorsal translatoric mobilization of C0-C1 in the cervical neutral position. C7 intervention consisted of a ventral cranial translatoric mobilization of C7-T1 in neutral position and the control group maintained a supine position. C0 group experienced a FRT ROM to the restricted side increase of $17.64^{\circ}$(SD=4.55), that was significantly greater (P<0.001) than $5.95^{\circ}$(SD=4.81) of the C7 group and $2.45^{\circ}$(SD=5.05) of the control group. The results showed that a dorsal translatoric mobilization of C0-C1 in neutral position restored the physiological FRT mobility in subjects with C1-C2 hypomobility and experienced statistical significant improvement in FRT as compared to a C7-T1 translatoric mobilization and a control group. (Level of evidence: 1b).