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Destruction of Tissue Architecture Induced by Dust Particles in Inkjet Bioprinted Alveolar Barrier
Dayoon KANG,Sungjune JUNG 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Atmosphere dust particles travel into our body via the airway and cause damages to our respiratory system, which causes severe respiratory diseases. Therefore, the need for studies to analyze the effects of dust particles on the respiratory system has been emphasized. However, most studies about the toxicity of dust have been carried out in two-dimensional cell culture, animal models, and epidemiological investigations. To figure out how dust can cause respiratory disease, it is necessary to examine using a reliable three-dimensional structured model, which mimics human nature alveoli. In this study, we applied atmospheric dust particles in dose- and time-dependent manner on our previously developed three-dimensional alveolar barrier, which is generated by the inkjet bioprinting process. As results, we observed destruction of tissue architecture along with cell death in our engineered alveolar barrier. Based on the damages in cellular levels, we observed increased pro-inflammatory cytokines, which trigger the signal transduction pathway leading to the activation of transcription factors. As cascades of release of cytokines, we confirmed a degradation of extracellular matrix, which might induce a collapse of the structure, loss of cell polarity, and a decreased barrier tightness. We further investigated pulmonary surfactant protein-related genes in dust-treated alveolar tissue then we could estimate the possible harmful effect of dust on pulmonary surfactant dysfunction. This study demonstrated the physiological impact of dust on cytotoxicity effects, alveolar barrier rigidity, and surfactant secretion using inkjet bioprinted alveolar barrier in gene expression level. Additionally, it has been demonstrated that dust can have serious consequences that can lead to the collapse of the tissue structure. We expect that this strategy using in vitro inkjet bioprinted 3D alveolar barrier can be a useful tool for identifying pollutant exposure-related diseases.
Display-control spatial mapping problem : Revisit to four-hotplate stovetop design
Songyi Chae,Dayoon Kang,Jiwon Yeon,Gyouhyung Kyung 대한인간공학회 2012 대한인간공학회 학술대회논문집 Vol.2012 No.5
Objective: The aim of this study was twofold-1) to identify user-preferred spatial arrangements of four pairs of hotplate and control, and 2) to investigate the effects of initial design constraints on the user preference. Background: Most stove layout designs come with squarely arranged 4 hotplates with different locations/alignments for their controls. Prior studies on the stovetop layout problem, however, were done with some initial design constraints (e.g., hotplates first placed on the stovetop). Method: Twenty participants were asked to place 4 hotplates and 4 controls at any place on the stovetop they preferred (without preoccupation of either hotplate or control), and then to couple each hotplate with each control. In the second session, 4 hotplates or controls were placed first on the stovetop, and then remaining parts were placed by the participants. Results: One spatial arrangement was predominant in the first session, while three were in the second session. Conclusion: Initial design constraints appeared to affect display-control mapping preferences. Application: The findings imply that a ny initial design constraint should be carefully allowed for when determining any display-control mapping solution based on user preference.