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Chu, Jia-Qi,Kim, Su-Mi,Lee, Kwang-Nyeong,Oem, Jae-Ku,Ko, Young-Joon,Lee, Hyang-Sim,Kim, Yong-Joo,Park, Jee-Yong,Kim, Kwang-Jae,Parida, Satya,Oh, Yooni,Paton, David J.,Joo, Yi-Seok,Kim, Byounghan,Park, The Korean Society for Microbiology 2012 Journal of Bacteriology and Virology Vol.42 No.3
Interferon is an important cytokine that plays a critical role in the initial host defense against viral infection. Recombinant human adenoviruses expressing human interferon-${\alpha}$ (Ad-$HIFN{\alpha}$) or pig interferon-${\beta}$ fused with interleukin-18 (Ad-$PIFN{\beta}$-IL18) were constructed and used to induce an early protective response against foot and mouth disease (FMD). To analyze the antiviral effect, bovine thyroid and porcine kidney IBRS-2 cells and ICR mice were treated with Ad-$HIFN{\alpha}$, Ad-$PIFN{\beta}$-IL18, and cocktail of Ad-$HIFN{\alpha}$ and Ad-$PIFN{\beta}$-IL18. The survival rate of suckling mice was monitored after foot and mouth disease virus (FMDV) challenge following intra-peritoneal (IP) administration of appropriate adenovirus. Indirect antigen ELISA was performed to evaluate inhibition of FMDV replication following challenge with the FMDV O, A, or Asia 1 serotypes in vitro. These recombinant adenoviruses reduced the replication of FMDV in susceptible cells, thereby decreasing the fatality in mice, suggesting that they can be a useful control method for the early protection against FMD infection in livestock after field trial.