http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Dave H. Schweitzer (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Paddy K.C. Janssen,Daan Touw,Dave H. Schweitzer,Marcel D. Waldinger 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.9
Purpose: Nonresponse to any selective serotonin reuptake inhibitor (SSRI) treatmentis rare. In this study, we aimed to investigate ejaculation delay nonresponse to paroxetinetreatment in men with lifelong premature ejaculation (PE) who were also knownto be nonresponders to other SSRIs. Materials and Methods: Five males with lifelong PE who were known nonrespondersto paroxetine and other serotonergic antidepressants and eight males with lifelong PEwho were specifically recruited were included. Blood sampling occurred 1 month and1 day before the start of treatment and at the end of three consecutive series of 4 weeksof daily treatment with 10-, 20-, and 30-mg paroxetine, respectively. Blood samples formeasurement of leptin and paroxetine were taken at 8:30 AM, 9:30 AM, 10:30 AM, and11:30 AM, respectively. At 9:00 AM, one tablet of 10-, 20-, or 30-mg paroxetine was takenduring the first, second, and third month, respectively. Intravaginal ejaculatory latencytime (IELT) was measured with a stopwatch. The main outcome measures were the foldincrease in the geometric mean IELT, serum leptin and paroxetine concentrations, bodymass index (BMI), 5-HT1A receptor C-1019G polymorphism, and CYP2D6 mutations. Results: Between the 7 paroxetine responders and 6 nonresponders, the fold increasein the geometric mean IELT was significantly different after daily 10-mg (p=0.003),20-mg (p=0.002), and 30-mg paroxetine (p=0.026) and ranged from 2.0 to 8.8 and from1.1 to 1.7, respectively. BMI at baseline and at the end of the study was not significantlydifferent between responders and nonresponders. Serum leptin levels at baseline weresimilar in responders and nonresponders and did not change during treatment. Theserum paroxetine concentration increased with increasing dosage and was not significantlydifferent between responders and nonresponders. There was no associationbetween the fold increase in the geometric mean IELT and serum paroxetine levels duringthe three treatment periods nor between leptin levels during the treatment periodsand serum paroxetine levels. For the 5-HT1A receptor C-1019G variation, all respondershad the CC genotype and all nonresponders had the GC genotype, respectively. Conclusions: Complete absence of paroxetine-induced ejaculation delay is presumably relatedto pharmacodynamic factors and perhaps to 5-HT1A receptor gene polymorphism.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
