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Zhimin Xu,Yingxin Zhang,Huanyan Dai,Yu Wang,Yujie Ma,Shuang Tan,Bing Han 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-
Obtaining a safe and reliable scaffold that can be rapidly fabricated and used for clinical bone defect repairhas always been a challenge. In this study, polycaprolactone (PCL) composite scaffolds with various MXene(Ti2AlN) contents were prepared using 3D printing technology. The effects of different contents of Ti2AlNon the mechanical properties, hydrophilicity, cytocompatibility, and osteogenic differentiation abilitywere systematically studied and analysed. In vitro experiments showed that scaffolds containing 5%Ti2AlN (PCL@5#Ti2AlN) obtained the best cell adhesion and proliferation ability and significantly upregulatedthe alkaline phosphatase (ALP) level. In vivo experiments of tibial defect repair in rats showed thatthe PCL scaffold containing 5% Ti2AlN (PCL@5#Ti2AlN) could significantly promote the formation of newbone, and the experimental results of rabbit maxillofacial bone defect repair further proved that thePCL@5#Ti2AlN scaffold could effectively promote the repair of bone defects. Transcriptome analysis indicatedthat Ti2AlN may promote osteogenic differentiation by the Wnt/b-catenin signaling pathway andcalcium-binding proteins. These findings suggest that Ti2AlN/PCL composite scaffolds with improvedin situ bone repair ability represent an intelligent strategy for bone defect repair.
Yuan Lu,Hongqian Dai,Pengpeng Cheng,Hanbing Shi,Lan Tang,Xingyuan Sun,Zhimin Ou 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.5
A modular approach was applied for the synthesis of bienzyme-polymer nanoconjugates (nano-BECs) (50- 70 nm) consisting of two enzymes (carbonyl reductase and glucose dehydrogenase) conjugated within a single universal polymer scaffold. The amount of the product ethyl (R)-2-hydroxy-4-phenylbutyrate (R-HPBE) with nano-BECs as the catalyst was 533mM in a dibutyl phthalate-phosphate buffer (dibutyl phthalate-PB) biphasic system, while the amount of R-HPBE was 349mM using carbonyl reductase-poly(acrylic acid) as the catalyst, indicating that the nano- BECs have an advantage for coenzyme regeneration. Compared with a single aqueous phase, the substrate treatment capacity was improved at the interface of the dibutyl phthalate-PB biphasic system. Under the optimal reaction conditions (35 oC, 40 h, dibutyl phthalate-PB 1 : 1), nano-BECs can completely convert substrate into optically pure R-HPBE (enantiomeric excess (e.e.) >99.9%) in the organic-aqueous system.
Zhu Yinan,Lin Zuokang,Yu Haiyan,Yu Xiaohan,Dai Zhimin 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.5
Beam shaping assembly (BSA) is a vital component in Boron Neutron Capture Therapy (BNCT) for obtaining epithermal neutron beams. Several feasible designs of BSA for accelerator-based BNCT (AB-BNCT) neutron source are carried out based on neutrons by bombarding a natural lithium target with 10 mA, 2.8 MeV proton beams. The calculation results demonstrate that a thickness of 45 cm is appropriate for general moderators referring to the therapeutic parameter of Advanced Depth (AD). A series of optimizations are performed and two results are confirmed: One is that employing the configuration of MgF2 and FLUENTAL combined by 1:1 could improve the therapeutic rate (TR) of tumors at a depth of middle region, and the other one is that the TR of superficial tumors can be increased by adding a 5 cm thick boron-11 secondary moderator at the end of general moderators. As a result, an innovative conception of an adjustable moderator is recommended to BNCT. Compared to the MgF2 moderator with a fixed thickness of 45 cm, the TR value can be improved by a maximum of 47.7 % by using the adjustable moderator. Furthermore, the configuration of adjustable moderator has been designed with regulation method for treating tumors of different depths.