흰쥐 Kupffer 세포에 대한 Propofol의 작용

박세훈,지대림,성언기,김희선,송인환,박희영,김준수,이덕희,박대팔 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: Propofol has an antioxidant capacity and can be used for ischemia-reperfusion injury of the liver. However, the effects of propofol on the Kupffer cells have not been establisked. Methods: Kupffer cells were isolated and cultured from male Sprague-Dawley rats. The effects of propofol on the Kupffer cells were evaluated by a phagocytosis assay, TNF-α gene expression, and superoxide anion release after administering propofol in different concentrations on the cultured Kuprrer cells. Results: The latex bead phagocytosis by the Kupffer cells was suppressed when the Kupffer cells were exposed to propofol irrespective of concentrations. Higher propofol concentrations decreased the loss of Kupffer cells after latex bead phagocytosis. Propofol induced TNF-α mRNA expression in the Kupffer cells, but the mRNA expression level after 50㎍/ml of propofol decreased. The pattern of TNF-α mRNA expression induced by propofol was different to that induced by LPS: TNF-α mRNA was expressed continuously in the propofol-treated cells until 16 hours after exposure to propofol, whereas the level of TNF-α mRNA expression induced by LPS was evident after 2 hours and was not found thereafter. TNF-α production after propofol treatment was not higher than that of the control. Formazan presipitation did not show any qualitative differences between cells untreated or treated with propofol concentrations of 0.5, 5.0, and 50 ㎍/ml. Conclusions: These results showed that propofol might inhibit Kupffer cells. This suggests that propofol and be used for patients with ischemia-reperfusion injury of the liver. (Korean J Anesthesiol 2002; 43: 475~484)

수지말단부 손상의 분류와 재건

박대환,한동길,안기영 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3

Finger tip injuries are in increasing tendency and the treatment must be focused toward preserving length and providing normal sensitivity. The 61 injured digits distal to DIT joint in 49 patients were managed in various procedures from May, 1990 to June, 1991. The authors classified the injured digits into 6 groups and selected the best surgical procedures according to the extent of the injuries. The 6 groups were : A. Volar skin and pulp loss without exposed bone B. Large volar skin and pulp loss with exposed distal phalanx C. Straight-transecton involving nail bed injury. D. Dorsally directed injury with little remaining nail bed E. Germinal matrix injury F. Injury at DIT joint level Tentatively recomonended surgical procedures by the extent of injury were : 1. Secondary intention or skin graft for level A 2. Local flap coverage for level B 3. Composite graft or Local advancement flap for level C 4. Local flap coverage or primary closure after bone shortening and residual nail ablation for group D 5. Micro-replantation or distant flap or local flap according to the state of the injury for group E and F

METRx™ 기구를 이용한 후방 경추부 추궁추간공 제거술의 예비 결과

박형천,윤승환,박종운,하윤,현동근,김은영,박현선,임대철 대한척추신경외과학회 2004 Neurospine Vol.1 No.1

Objectives: Posterior cervical microscopic laminoforaminotomy has been a preferred procedure for a posterolateral cervical disc or foraminal stenosis. However, neckpain from wide skin incision and muscle injury are some of disadvantages. The authors performed cervical microscopic laminoforaminotomy with METRx™ tubular dilator system and were compared the results with classical cervical microscopic foraminotomy. Methods: Six patients underwent posterior cervical microscopic laminoforaminotomy using the METRx™ during 6 months. We have selected 10 patients from our institution as a comparison group. Preoperative and postoperative pain score composed of the radicular and neck component was examined and disability score also recorded. Diameters and lengths of laminoforaminotomy on the postoperative CT also were compared with two methods Results: Postoperative pain scores to the radiculopathies were not different but postoperative pain scores to the neckpain on the follow up periods were significantly different. The average vertical and transverse diameters of the laminoforaminotomy defect on the postoperative CT scans were not different between two groups. Average hospital stay of the classical methods was 8.8±7.5 days comparison with 4.5±0.54days of new procedure. Conclusions: Posterior cervical microscopic laminoforaminotomy with METRx™ systems seems to provide similar decompression and clinical results as classical methods compared to classical methods and shows superior results for postoperative neckpain and hospital stays.

매몰이의 교정

박대환,김태모,한동길,안기영 대구효성가톨릭대학교 1998 연구논문집 Vol.57 No.2

Cryptotia is deformity of the antihelix, especially its superior crus. There are various available methods that can be used for the surgical correction of cryptotia, but their main purposed is the provision of skin for the upper part of the skin and correction of deformed cartilage. We have repaired 13 cryptotia deformities in 9 patients with aesthetically satisfactory results using Z-plasty for auriclocephalic sulcus correction and vertical incision at superior crus of antihelix and then mattress suture or cartilage graft from cavum of concha for cartilage correction.

F. Kafka의 "Der Prozeβ" 解釋試圖 : 罪의 問題를 中心으로

朴大桓 조선대학교 인문학연구소 1983 外國文化硏究 Vol.6 No.1

Der Prozeb는 "In der Strafkolonie"와 "Das Urteil"과 Thema면에서 공통성을 지니고 있다. 이러한 작품들 속에는 매우 강렬한 음조로 막강한 힘에 대한 저항, 그리고 죄와 벌의 문제가 표출되고 있다.

원위부를 기초로 한 도서형 정맥 피판의 임상적 응용

박대환,황동하,안기영 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.6

Skin flaps are characterised by arterial inflow and venous outflow. Since Baek et al(1985) demonstrated experimentally the possibility of raising a flap based only on a single vein surviving without arterial inflow, experimental and clinical attempts in using the 'flow through' venous flap, proximally pedicled venous flap, and distally pedicled venous flap have been performed and developed. In our study, five flaps with only a distal venous pedicle were carried out; two saphenous venous flap, one cephalic venous flap, one external jugular venous flap, and one dorsal venous flap of hand. Four of these five survived completely without complication but only the external jugular venous flap showed partial necrosis. These flaps are useful because of almost infinite donor site, quicker and simpler technique than free flap, and little donor site morbidity. Further studies are required for improved survival rate of venous flap.

매몰이의 연골 변형의 교정

박대환,김태모,한동길,안기영 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.5

The key points of treatment of cryptotia are the elevation of invaginated ear helix and the correction of deformed cartilage. Prevention of stabilized cartilage contouring from returning to the previous state is also important. The authors carried cartilage plasty by modified Fukuda's method that several incisions are made along the crus, and then the crus is flattened using mattress suture in cases of mild cartilage deformity. In cases of severe cartilage deformity, the cartilage plasty by Onizuka method was carried. The cartilage graft from cavum on concha served as a splint for prevention of recurrence of cartilage deformities. We have repaired 13 cryptotic deformities in 9 patients with aesthetically satisfactory results using vertical incision at the superior crus of antihelix with mattress suture or cartilage graft from cavum of concha for cartilage correction. The correction of deformed cartilage by modified Fukida or Onizuka method is a good option for the treatment of cryptotia.

F. Du¨rrenmatt의 희곡 "Romulus der Groβe"연구 : 時代批判의 問題를 中心으로 Unter besonderer Beru¨cksichtigung der Zeitkritik

박대환 조선대학교 외국문화연구소 1987 外國文化硏究 Vol.10 No.1

한랭작업 근로자들의 건강위해에 관한 연구

박호추,정설미,문덕환,이종태,김대환,김정호,최재일,황용식,이용희,이채언 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1

In order to evaluate the status of cold exposure and its health hazards of workers at cold storage workplaces and to provide basic data for effective health care, the author measured core temperature and also observed clinical symptoms and signs, past and present history, and general health examination data on 99 cold exposed workers for exposure group and 96 non-exposed workers for control group working at 2 food refrigerating companies in Pusan area from January 6, 1998 to February 24, 1998. The results were as follows: 1. There was statistically significant difference in water intake between the exposure and control group and increased urine volume, urine frequency in exposure group without statistically significant difference. 2. Past and present illness in exposure group were hypertension (18.2%), hepatopathy (8.1%), gastro-intestinal disease(7.1%), arthritis (4.0%), intervertebral disc herniation(4.0%), and so on, and hypertension, arthritis was statistically significant difference compared to control group. 3. Symptoms in exposure group were fatigue(89.9%), headache (64.6%). drowsy(63.6%), neck stiffness(59.6%), excessive food intake(59.6%). general weakness(58.6%), hunger(58.6%), numbness(54.5%), and so on, and there was statistically significant difference between the exposure and control group except fatigue, drowsy. 4. As results of clinical test abnormality rate of the systolic, diastolic blood pressure and electrocardiogram were significantly higher in exposed group than control. 5. Core temperature in exposure group was statistically significantly lower than control group and the highest statistically significant inverse correlation with the working hours and working frequency of daily mean cold storage. As above results, the author suggested that the further studies should be conducted to evaluate the health status of workers about chronic health effects in cold workplaces and to establish effective health care methods for them.

좌골부 욕창의 치료

박대환,한동길,안기영 대구효성가톨릭대학교 1996 연구논문집 Vol.53 No.2

Ischial ulcers are the most common of all pressure ulcers, probably because they directly overlie the points of maximum pressure on the sitting surface. Furthermore, they are among the most common secondary ulcers for the same reason. Also, ischial ulcers are frequently complicated by abnormal lesional bursae, by extension, fistula toward the perineum, urethra, or peritoneal cavity. Urethrograms or panendoscopy are necessary prior to surgery and must remove all irreversibly damaged tissue. Consequently any surgical plan for ischial ulcers must take into account the effects of bone removal on weight bearing and positioning, and must provide stable, durable soft tissue cover intelligently designed to be reliable in the event of a recurrence. From April 1990 to April 1993, we had reconstructed 15 cases of ischial ulcers. In 13 cases of primary ulcers, inferior gluteil thigh flip (7 case), transpositin flap(2 case), ischiectomy and direct closure (3 cases), gluteus maximus myocutaneous island flap(1 case) was done. In 2 cases of secondary ulcers, V-Y advancement flap of biceps femoris and semitendinosus and gracillis muscle flap were done each other.