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Kim, So-Jung,Jeon, Da-Bin,Park, Jung-Ho,Ryu, Min-Ki,Yang, Jong-Heon,Hwang, Chi-Sun,Kim, Gi-Heon,Yoon, Sung-Min American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.8
<P>Nonvolatile memory thin-film transistors (TFTs) fabricated on paper substrates were proposed as one of the eco-friendly electronic devices. The gate stack was composed of chicken albumen gate insulator and In–Ga–Zn-O semiconducting channel layers. All the fabrication processes were performed below 120 °C. To improve the process compatibility of the synthethic paper substrate, an Al<SUB>2</SUB>O<SUB>3</SUB> thin film was introduced as adhesion and barrier layers by atomic layer deposition. The dielectric properties of biomaterial albumen gate insulator were also enhanced by the preparation of Al<SUB>2</SUB>O<SUB>3</SUB> capping layer. The nonvolatile bistabilities were realized by the switching phenomena of residual polarization within the albumen thin film. The fabricated device exhibited a counterclockwise hysteresis with a memory window of 11.8 V, high on/off ratio of approximately 1.1 × 10<SUP>6</SUP>, and high saturation mobility (μ<SUB>sat</SUB>) of 11.5 cm<SUP>2</SUP>/(V s). Furthermore, these device characteristics were not markedly degraded even after the delamination and under the bending situration. When the curvature radius was set as 5.3 cm, the <I>I</I><SUB>ON</SUB>/<I>I</I><SUB>OFF</SUB> ratio and μ<SUB>sat</SUB> were obtained to be 5.9 × 10<SUP>6</SUP> and 7.9 cm<SUP>2</SUP>/(V s), respectively.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2015/aamick.2015.7.issue-8/am508834y/production/images/medium/am-2014-08834y_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am508834y'>ACS Electronic Supporting Info</A></P>
Shin Yoo-Sub,Hwang Da-Bin,Won Dong-Hoon,Kim Shin-Young,Kim Changuk,Park Jun Won,Jeon Young,Yun Jun-Won 한국독성학회 2023 Toxicological Research Vol.39 No.3
Drug-induced liver injury (DILI) is a major cause of acute liver failure and drug withdrawal. Cytochrome P450 (CYP) 2E1 is involved in the metabolism of several drugs, and can induce liver injury through the production of toxic metabolites and the generation of reactive oxygen species. This study aimed to elucidate the role of Wnt/β-catenin signaling in CYP2E1 regulation for drug-induced hepatotoxicity. To achieve this, mice were administered cisplatin or acetaminophen (APAP) 1 h after treatment with the CYP2E1 inhibitor dimethyl sulfoxide (DMSO), and histopathological and serum biochemical analyses were performed. APAP treatment induced hepatotoxicity, as evidenced by an increase in liver weight and serum ALT levels. Moreover, histological analysis indicated severe injury, including apoptosis, in the liver tissue of APAP-treated mice, which was confirmed by TUNEL assay. Additionally, APAP treatment suppressed the antioxidant capacity of the mice and increased the expression of the DNA damage markers γ-H2AX and p53. However, these effects of APAP on hepatotoxicity were significantly attenuated by DMSO treatment. Furthermore, the activation of Wnt/β-catenin signaling using the Wnt agonist CHIR99021 (CHIR) increased CYP2E1 expression in rat liver epithelial cells (WB-F344), whereas treatment with the Wnt/β-catenin antagonist IWP-2 inhibited nuclear β-catenin and CYP2E1 expression. Interestingly, APAP-induced cytotoxicity in WB-F344 cells was exacerbated by CHIR treatment and suppressed by IWP-2 treatment. Overall, these results showed that the Wnt/β-catenin signaling is involved in DILI through the upregulation of CYP2E1 expression by directly binding the transcription factor β-cat/TCF to the Cyp2e1 promoter, thus exacerbating DILI.
Ko, Young Ok,Jeon, Hyun Ji,Jung, Da Jung,Kim, U Bin,Lee, Sang-gi American Chemical Society 2016 ORGANIC LETTERS Vol.18 No.24
<P>A novel, one-pot route for the synthesis of nonaromatic ring fused 1,4-oxazepines and 1,4-oxazines has been developed. The reaction features a sequential rhodium(II)-catalyzed reaction of N-sulfonyl-1,2,3-triazoles with glycidols, followed by a regioselective Lewis acid Mg((OBu)-Bu-t)(2)-catalyzed intramolecular ring-opening reaction. It has been found that the regioselectivity in the epoxide ring-opening was largely determined by the substituents on the glycidols. Thus, substituted glycidols (R-2 not equal H) afforded seven-membered oxazepine derivatives selectively, while unsubstituted glycidols (R-2 = H) afforded six-membered oxazine derivatives. Plausible reaction pathways are elucidated and supported by experiments with several glycidols bearing different substituents around the epoxide functionality.</P>