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Kim, Kyoung-Ran,Kim, Da-Rae,Lee, Taemin,Yhee, Ji Young,Kim, Byeong-Su,Kwon, Ick Chan,Ahn, Dae-Ro The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.20
<P>A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.</P> <P>Graphic Abstract</P><P>A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc38693g'> </P>
A Genome-Wide Analysis of Antibiotic Producing Genes in Streptomyces globisporus SP6C4
Da-Ran Kim,Youn-Sig Kwak 한국식물병리학회 2021 Plant Pathology Journal Vol.37 No.4
Soil is the major source of plant-associated microbes. Several fungal and bacterial species live within plant tissues. Actinomycetes are well known for producing a variety of antibiotics, and they contribute to improving plant health. In our previous report, Streptomyces glo- bisporus SP6C4 colonized plant tissues and was able to move to other tissues from the initially colonized ones. This strain has excellent antifungal and antibacterial activities and provides a suppressive effect upon various plant diseases. Here, we report the genome-wide analysis of antibiotic producing genes in S. globisporus SP6C4. A total of 15 secondary metabolite biosynthetic gene clusters were predicted using antiSMASH. We used the CRISPR/Cas9 mutagenesis system, and each biosynthetic gene was predicted via protein basic local alignment search tool (BLAST) and rapid annotation using subsystems technology (RAST) server. Three gene clusters were shown to exhibit antifungal or anti- bacterial activity, viz. cluster 16 (lasso peptide), cluster 17 (thiopeptide-lantipeptide), and cluster 20 (lanti- peptide). The results of the current study showed that SP6C4 has a variety of antimicrobial activities, and this strain is beneficial in agriculture.
Antifungal Properties of Streptomyces bacillaris S8 for Biological Control Applications
Da-Ran Kim,Chang-Wook Jeon,Youn-Sig Kwak The Korean Society of Plant Pathology 2024 Korean journal of plant pathology Vol.40 No.3
Soybean (Glycine max), a crucial global crop, experiences yearly yield reduction due to diseases such as anthracnose (Colletotrichum truncatum) and root rot (Fusarium spp.). The use of fungicides, which have traditionally been employed to control these phytopathogens, is now facing challenges due to the emergence of fungicide-resistant strains. Streptomyces bacillaris S8 strain S8 is previously known to produce valinomycin t through a nonribosomal peptide synthetase (NRPS) pathway. The objective of this study was to evaluate the antifungal activity of S. bacillaris S8 against C. truncatum and Fusarium sp., assessing its efficacy against soybean pathogens. The results indicate that strain S8 effectively controlled both above-ground and underground soybean diseases, using the NRPS and NRPS-related compound, suggesting its potential as a biological control in plant-microbe interactions. These findings underscore the pivotal role of the stain S8 in fostering healthy soybean microbial communities and emphasize the significance of microbiota structure studies in unveiling potent biocontrol agents.
Kim Sung Ran,Kang Hyeon Jeong,Jeong Hye Rin,Jang Su Yeon,Lee Jae Eun,Kim Da Eun,Lee Hae Ry,Cho Min Hee,Noh Ji Yun,Cheong Hee Jin,Kim Woo Joo,Song Joon Young 대한의학회 2022 Journal of Korean medical science Vol.37 No.35
The omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to have high infectivity and is more likely to evade vaccine immunity. However, booster vaccination is expected to strengthen cross-reactive immunity, thereby increasing the vaccine effectiveness (VE). This study aimed to evaluate the relative VE of the 3-dose (booster) vaccination compared with the 2-dose primary series vaccination in healthcare workers during omicron variant-dominant periods. During the omicron-dominant period from February 1, 2022 to February 28, 2022, a 1:1 matched case-control study was conducted. Healthcare workers with positive SARS-CoV-2 test results were classified as positive cases, whereas those with negative results served as controls. Compared with the 2-dose primary series vaccination, booster vaccination with mRNA vaccine showed moderate VE (53.1%). However, in multivariate analysis including the time elapsed after vaccination, the significant VE disappeared, reflecting the impact of recent vaccination rather than the third dose itself.
Using EMG Sensor WooridulChair Usability Evaluation
Da Seu Ran Kim,Sung Koon Lee,Peom Park 대한인간공학회 2011 대한인간공학회 학술대회논문집 Vol.2011 No.5
Background: Recently, modern people most of the time learning or office work is carried out sitting in a chair and neck, shoulder, back and waist pain on people are increasing by the upper body fatigue that comes from a long time incomplete position. Objective: Therefore in this study, when office work and learning activities time for the prevention of musculoskeletal disorders, on the chest support of the chair and stool for the existing process through usability testing is to verify the effectiveness. Method: Especially, progressed measurement that use EMG sensor and surveyed to evaluate fatigue degree of reagent's upper body main region simultaneously. The 20~27 year-old college students subject, 6 or more hours daily use chairs, 1 hour in a given situation, neck, shoulders, back and waist were measured at the EMG. Results: In the case of experiment result chest support chair, keep attitude right relatively, can know that fatigue degree of muscle appears to be less than general chair. Conclusion: Through this study, the chest support chair's effects for the maintenance of good posture and the could be verified, of the future, development of office chairs is expected to have a positive impact.
Kim, Da-Ran,Gang, Gun-hye,Jeon, Chang-Wook,Kang, Nam Jun,Lee, Sang-woo,Kwak, Youn-Sig The Korean Society of Plant Pathology 2016 Plant Pathology Journal Vol.32 No.4
Strawberry bacterial angular leaf spot (ALS) disease, caused by Xanthomonas fragariae has become increasingly problematic in the strawberry agro-industry. ALS causes small angular water-soaked lesions to develop on the abaxial leaf surface. Studies reported optimum temperature conditions for X. fragariae are $20^{\circ}C$ and the pathogen suffers mortality above $32^{\circ}C$. However, at the nursery stage, disease symptoms have been observed under high temperature conditions. In the present study, results showed X. fragariae transmission was via infected maternal plants, precipitation, and sprinkler irrigation systems. Systemic infections were detected using X. fragariae specific primers 245A/B and 295A/B, where 300-bp and 615-bp were respectively amplified. During the nursery stage (from May to August), the pathogen was PCR detected only in maternal plants, but not in soil or irrigation water through the nursery stage. During the cultivation period, from September to March, the pathogen was detected in maternal plants, progeny, and soil, but not in water. Additionally, un-infected plants, when planted with infected plants were positive for X. fragariae via PCR at the late cultivation stage. Chemical control for X. fragariae with oxolinic acid showed 87% control effects against the disease during the nursery period, in contrast to validamycin-A, which exhibited increased efficacy against the disease during the cultivation stage (control effect 95%). To our knowledge, this is the first epidemiological study of X. fragariae in Korean strawberry fields.
Da-Ran Kim,이수인,곽연식 한국식물병리학회 2023 Plant Pathology Journal Vol.39 No.6
The aim of this study was to investigate the regulation of lantipeptide production in Streptomyces globisporus SP6C4, which produces the novel antifungal lantipeptides conprimycin and grisin, and to identify the role of cytochrome P450 (P450) in tis regulation. To investigate the regulation of lantipeptide production, we created gene deletion mutants, including ΔP450, ΔtsrD, ΔlanM, ΔP450ΔtsrD, and ΔP450ΔlanM. These mutants were characterized in terms of their morphology, sporulation, attachment, and antifungal activity against Fusarium oxysporum. The gene deletion mutants showed distinct characteristics compared to the wild-type strain. Among them, the ΔP450ΔlanM double mutant exhibited a recovery of antifungal activity against F. oxysporum, indicating that P450 plays a significant role in regulating lantipeptide production in S. globisporus SP6C4. Our findings highlight the significant role of P450 in the regulation of lantipeptide production and morphological processes in S. globisporus. The results suggest a potential link between P450-mediated metabolic pathways and the regulation of growth and secondary metabolism in SP6C4, thereby highlighting P450 as a putative target for the development of new antifungal agents.